Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine
There are approximately 40% of new drug molecules discovered and some drugmolecules that are available in the market, having poor bioavailability due to poorsolubility and/or poor permeability. The present study aimed at formulating a selfmicroemulsifying drug delivery system (SMEDDS) using two BCS...
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| Format: | Thesis |
| Language: | English |
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2010
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| Online Access: | http://eprints.usm.my/41728/1/CHITNENI_MALLIKARJUN.pdf |
| _version_ | 1825834484042301440 |
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| author | Chitneni , Mallikarjun |
| author_facet | Chitneni , Mallikarjun |
| author_sort | Chitneni , Mallikarjun |
| collection | USM |
| description | There are approximately 40% of new drug molecules discovered and some drugmolecules that are available in the market, having poor bioavailability due to poorsolubility and/or poor permeability. The present study aimed at formulating a selfmicroemulsifying drug delivery system (SMEDDS) using two BCS class IV drugs, namely sulpiride and norfloxacin. Sulpiride is a P-gp substrate and norfloxacin is a
substrate of MRP2, BCRP and an unknown efflux pump. |
| first_indexed | 2024-03-06T15:23:26Z |
| format | Thesis |
| id | usm.eprints-41728 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:23:26Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | usm.eprints-417282019-04-12T05:26:58Z http://eprints.usm.my/41728/ Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine Chitneni , Mallikarjun RS1-441 Pharmacy and materia medica There are approximately 40% of new drug molecules discovered and some drugmolecules that are available in the market, having poor bioavailability due to poorsolubility and/or poor permeability. The present study aimed at formulating a selfmicroemulsifying drug delivery system (SMEDDS) using two BCS class IV drugs, namely sulpiride and norfloxacin. Sulpiride is a P-gp substrate and norfloxacin is a substrate of MRP2, BCRP and an unknown efflux pump. 2010-01 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/41728/1/CHITNENI_MALLIKARJUN.pdf Chitneni , Mallikarjun (2010) Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Chitneni , Mallikarjun Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine |
| title | Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine |
| title_full | Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine |
| title_fullStr | Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine |
| title_full_unstemmed | Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine |
| title_short | Oral Bioavailability Enhancement Of Poorly Soluble And Poorly Permeable Drugs Using Self-Microemulsifying Drug Delivery Systems And The Effect Of Piperine |
| title_sort | oral bioavailability enhancement of poorly soluble and poorly permeable drugs using self microemulsifying drug delivery systems and the effect of piperine |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/41728/1/CHITNENI_MALLIKARJUN.pdf |
| work_keys_str_mv | AT chitnenimallikarjun oralbioavailabilityenhancementofpoorlysolubleandpoorlypermeabledrugsusingselfmicroemulsifyingdrugdeliverysystemsandtheeffectofpiperine |