Genetic Study Of Pocket A And B Domain Of RB1 Gene Among Malaysian Children With Retinoblastoma
Retinoblastoma (RB) is the most common intraocular tumor mainly affecting children under four years of age, with a prevalence of 1 in 15 000 to 20 000 live births. Retinoblastoma is divided into hereditary and non-hereditary types. The development of this malignancy requires both alleles of the tum...
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| Format: | Thesis |
| Language: | English |
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2009
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| Online Access: | http://eprints.usm.my/41836/1/HANANI_BINTI_AHMAD_YUSOF%40HANAFI.pdf |
| _version_ | 1825834504637382656 |
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| author | Hanafi, Hanani Ahmad Yusof |
| author_facet | Hanafi, Hanani Ahmad Yusof |
| author_sort | Hanafi, Hanani Ahmad Yusof |
| collection | USM |
| description | Retinoblastoma (RB) is the most common intraocular tumor mainly affecting children under four years of age, with a prevalence of 1 in 15 000 to 20 000 live births.
Retinoblastoma is divided into hereditary and non-hereditary types. The development of this malignancy requires both alleles of the tumor suppressor gene RB1 to be knockedout. Recent studies found mutation occurred more frequently in the pocket A and B domain of RB1 gene. The present study was undertaken to identify the mutation in the pocket A and B domain of RB1 gene among retinoblastoma patients in Malaysia, and the association of the mutation to the laterality and stage of the tumor. |
| first_indexed | 2024-03-06T15:23:45Z |
| format | Thesis |
| id | usm.eprints-41836 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:23:45Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | usm.eprints-418362019-04-12T05:26:59Z http://eprints.usm.my/41836/ Genetic Study Of Pocket A And B Domain Of RB1 Gene Among Malaysian Children With Retinoblastoma Hanafi, Hanani Ahmad Yusof R5-920 Medicine (General) Retinoblastoma (RB) is the most common intraocular tumor mainly affecting children under four years of age, with a prevalence of 1 in 15 000 to 20 000 live births. Retinoblastoma is divided into hereditary and non-hereditary types. The development of this malignancy requires both alleles of the tumor suppressor gene RB1 to be knockedout. Recent studies found mutation occurred more frequently in the pocket A and B domain of RB1 gene. The present study was undertaken to identify the mutation in the pocket A and B domain of RB1 gene among retinoblastoma patients in Malaysia, and the association of the mutation to the laterality and stage of the tumor. 2009-12 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/41836/1/HANANI_BINTI_AHMAD_YUSOF%40HANAFI.pdf Hanafi, Hanani Ahmad Yusof (2009) Genetic Study Of Pocket A And B Domain Of RB1 Gene Among Malaysian Children With Retinoblastoma. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | R5-920 Medicine (General) Hanafi, Hanani Ahmad Yusof Genetic Study Of Pocket A And B Domain Of RB1 Gene Among Malaysian Children With Retinoblastoma |
| title | Genetic Study Of Pocket A And B Domain Of RB1 Gene Among
Malaysian Children With Retinoblastoma
|
| title_full | Genetic Study Of Pocket A And B Domain Of RB1 Gene Among
Malaysian Children With Retinoblastoma
|
| title_fullStr | Genetic Study Of Pocket A And B Domain Of RB1 Gene Among
Malaysian Children With Retinoblastoma
|
| title_full_unstemmed | Genetic Study Of Pocket A And B Domain Of RB1 Gene Among
Malaysian Children With Retinoblastoma
|
| title_short | Genetic Study Of Pocket A And B Domain Of RB1 Gene Among
Malaysian Children With Retinoblastoma
|
| title_sort | genetic study of pocket a and b domain of rb1 gene among malaysian children with retinoblastoma |
| topic | R5-920 Medicine (General) |
| url | http://eprints.usm.my/41836/1/HANANI_BINTI_AHMAD_YUSOF%40HANAFI.pdf |
| work_keys_str_mv | AT hanafihananiahmadyusof geneticstudyofpocketaandbdomainofrb1geneamongmalaysianchildrenwithretinoblastoma |