A study on the protective effects of calcium channel blockers against anoxic brain damage
Introduction It is now widely accepted that a rapid neuronal influx of Ca2+ following cerebral ischaemia! hypoxia is intimately connected with the cascade of events- including activation of enzymes which give rise to the production of reactive oxygen species and nitric oxide, thereby leading to f...
| Main Authors: | , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
1997
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| Subjects: | |
| Online Access: | http://eprints.usm.my/42325/1/GP...A_Study_On_The_Protective_Effects_Of_Calcium_Channel_Blockers_Against_Anoxic_Brain_Damage...OCR.pdf |
| _version_ | 1797010805284143104 |
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| author | Sunil, Gurtu S.B, Acharya H. A., Nadiger Mohd, Shakil Siddiqui |
| author_facet | Sunil, Gurtu S.B, Acharya H. A., Nadiger Mohd, Shakil Siddiqui |
| author_sort | Sunil, Gurtu |
| collection | USM |
| description | Introduction
It is now widely accepted that a rapid neuronal influx of Ca2+ following cerebral ischaemia!
hypoxia is intimately connected with the cascade of events- including activation of enzymes which give
rise to the production of reactive oxygen species and nitric oxide, thereby leading to free-radical induced
damage -which reseult in neuronal injury and death. It is also known that a burst of free radical generation
I
occurs during re-oxygenation of the tissues following a period,ofischaernialhypoxia as also a prolonged
purturbation of the membrane functions continues after the perfusion/oxygenation has been restored, which
leads to continued accumulnnon of calcium intracellularly ; resulting ultimately in delayed damage and death
of the neurone.
Estimation of lipid peroxidation products proviqes a reliable estimate of free radical induced damage to
tissues, and has been widely used for this purpose. |
| first_indexed | 2024-03-06T15:25:07Z |
| format | Conference or Workshop Item |
| id | usm.eprints-42325 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:25:07Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | usm.eprints-423252020-03-20T04:33:42Z http://eprints.usm.my/42325/ A study on the protective effects of calcium channel blockers against anoxic brain damage Sunil, Gurtu S.B, Acharya H. A., Nadiger Mohd, Shakil Siddiqui R Medicine (General) Introduction It is now widely accepted that a rapid neuronal influx of Ca2+ following cerebral ischaemia! hypoxia is intimately connected with the cascade of events- including activation of enzymes which give rise to the production of reactive oxygen species and nitric oxide, thereby leading to free-radical induced damage -which reseult in neuronal injury and death. It is also known that a burst of free radical generation I occurs during re-oxygenation of the tissues following a period,ofischaernialhypoxia as also a prolonged purturbation of the membrane functions continues after the perfusion/oxygenation has been restored, which leads to continued accumulnnon of calcium intracellularly ; resulting ultimately in delayed damage and death of the neurone. Estimation of lipid peroxidation products proviqes a reliable estimate of free radical induced damage to tissues, and has been widely used for this purpose. 1997-02-01 Conference or Workshop Item NonPeerReviewed application/pdf en http://eprints.usm.my/42325/1/GP...A_Study_On_The_Protective_Effects_Of_Calcium_Channel_Blockers_Against_Anoxic_Brain_Damage...OCR.pdf Sunil, Gurtu and S.B, Acharya and H. A., Nadiger and Mohd, Shakil Siddiqui (1997) A study on the protective effects of calcium channel blockers against anoxic brain damage. In: IRPA Short Term Grant, 1st February, 1997, -. |
| spellingShingle | R Medicine (General) Sunil, Gurtu S.B, Acharya H. A., Nadiger Mohd, Shakil Siddiqui A study on the protective effects of calcium channel blockers against anoxic brain damage |
| title | A study on the protective effects of calcium channel blockers against anoxic brain damage |
| title_full | A study on the protective effects of calcium channel blockers against anoxic brain damage |
| title_fullStr | A study on the protective effects of calcium channel blockers against anoxic brain damage |
| title_full_unstemmed | A study on the protective effects of calcium channel blockers against anoxic brain damage |
| title_short | A study on the protective effects of calcium channel blockers against anoxic brain damage |
| title_sort | study on the protective effects of calcium channel blockers against anoxic brain damage |
| topic | R Medicine (General) |
| url | http://eprints.usm.my/42325/1/GP...A_Study_On_The_Protective_Effects_Of_Calcium_Channel_Blockers_Against_Anoxic_Brain_Damage...OCR.pdf |
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