Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities
Xanthorrhizol (1) is a bisabolane-type sesquiterpenoid obtained as the main constituent of the rhizome oil of temu lawak, Curcuma xanthorrhiza, which has been utilised as a tonic in Indonesia and as a choleretic drug in Europe. As regards to its bioactivities, it has been shown that xanthorrhizol (...
| Main Authors: | , |
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| Format: | Book Section |
| Language: | English |
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Penerbit Universiti Sains Malaysia
2004
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| Online Access: | http://eprints.usm.my/42516/1/pBIO35.pdf |
| _version_ | 1825834633501081600 |
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| author | Ngai, Mun Hong Sirat, Hasnah |
| author2 | Ahmad, Abdul Latif |
| author_facet | Ahmad, Abdul Latif Ngai, Mun Hong Sirat, Hasnah |
| author_sort | Ngai, Mun Hong |
| collection | USM |
| description | Xanthorrhizol (1) is a bisabolane-type sesquiterpenoid obtained as the main constituent of the rhizome oil of temu lawak, Curcuma xanthorrhiza, which has been
utilised as a tonic in Indonesia and as a choleretic drug in Europe. As regards to its bioactivities, it has been shown that xanthorrhizol (1) possessed antifungal activity against Candida albicans (MIC=68.75 μg/mL) and cytotoxic against human nasopharyngeal carcinoma cell line (KB, EC50 = 4.90 μg/mL) (Mata et al., 2001). Although the synthesis of 1 has been extensively
studied, the chemistry of this compound has only be studied in a limited extent. |
| first_indexed | 2024-03-06T15:25:38Z |
| format | Book Section |
| id | usm.eprints-42516 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:25:38Z |
| publishDate | 2004 |
| publisher | Penerbit Universiti Sains Malaysia |
| record_format | dspace |
| spelling | usm.eprints-425162018-11-02T03:21:31Z http://eprints.usm.my/42516/ Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities Ngai, Mun Hong Sirat, Hasnah Q179.9-180 Research Xanthorrhizol (1) is a bisabolane-type sesquiterpenoid obtained as the main constituent of the rhizome oil of temu lawak, Curcuma xanthorrhiza, which has been utilised as a tonic in Indonesia and as a choleretic drug in Europe. As regards to its bioactivities, it has been shown that xanthorrhizol (1) possessed antifungal activity against Candida albicans (MIC=68.75 μg/mL) and cytotoxic against human nasopharyngeal carcinoma cell line (KB, EC50 = 4.90 μg/mL) (Mata et al., 2001). Although the synthesis of 1 has been extensively studied, the chemistry of this compound has only be studied in a limited extent. Penerbit Universiti Sains Malaysia Ahmad, Abdul Latif Yahya, Ahmad Rahim Mohd Abdullah, Amirul AI-Ashraf Muhammad, Tengku Sifzizul Tengku 2004 Book Section PeerReviewed application/pdf en http://eprints.usm.my/42516/1/pBIO35.pdf Ngai, Mun Hong and Sirat, Hasnah (2004) Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities. In: The 4th Annual Seminar of National Science Fellowship NSF 2004 Proceedings. Penerbit Universiti Sains Malaysia, Pulau Pinang, Malaysia, pp. 181-186. |
| spellingShingle | Q179.9-180 Research Ngai, Mun Hong Sirat, Hasnah Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities |
| title | Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities |
| title_full | Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities |
| title_fullStr | Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities |
| title_full_unstemmed | Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities |
| title_short | Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities |
| title_sort | synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from c xanthorrhiza and their bioactivities |
| topic | Q179.9-180 Research |
| url | http://eprints.usm.my/42516/1/pBIO35.pdf |
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