The study of glucose-6-phosphate dehydrogenase (G6PD) gene by restriction enzyme by restriction enzyme digestion in the Kelantan population
The most common diseases producing enzymopathy affecting the human population is glucose-6-phosphate dehydrogenase (G6PD) deficiency. It is estimated that about 400 million people worldwide are affected and this disease is commonest seen in the tropical and subtropical zones of the Eastern hemispher...
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| Format: | Conference or Workshop Item |
| Language: | English |
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| Online Access: | http://eprints.usm.my/42642/1/GP...The_Study_Of_Glucose_-_6_-_Phosphate_Dehydrogenase_%28G6PD%29_Gene_By_Restriction_Enzyme_Digestion_In_The_Kelantan_Population..OCR...pdf |
| _version_ | 1797010868935852032 |
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| author | Yusoff, Narazah Mohd Jamaluddin, Normah Hussin, Zabidi Azhar Mohd Ee, Choo Keng Sein, Kyaw Tun |
| author_facet | Yusoff, Narazah Mohd Jamaluddin, Normah Hussin, Zabidi Azhar Mohd Ee, Choo Keng Sein, Kyaw Tun |
| author_sort | Yusoff, Narazah Mohd |
| collection | USM |
| description | The most common diseases producing enzymopathy affecting the human population is glucose-6-phosphate dehydrogenase (G6PD) deficiency. It is estimated that about 400 million people worldwide are affected and this disease is commonest seen in the tropical and subtropical zones of the Eastern hemisphere. Molecular analysis has confirmed that the basis for G6PD deficiency is widely heterogeneous. Different mutants are responsible for the G6PD deficiency in the various parts of the world where this abnormality is prevalent. This study involved a sequential analysis whereby the blood from Malay neonates with neonatal jaundice admitted to Hospital Universiti Sains Malaysia and Kota Bharu Hospital were analyzed and polymerase chain
reaction based analysis using serial multiplex primer method was done on those DNA samples. Samples that are
found to be abnormal were then sequenced. Out of the 45 samples studied, 8 were found to have the Mediterranean mutation, two have the Mahidol mutation, two have Canton
mutation and three have Kaiping mutation. Thus the molecular basis for the Malay neonatal jaundice in Kelantan is described with further prospect of population screening. |
| first_indexed | 2024-03-06T15:25:59Z |
| format | Conference or Workshop Item |
| id | usm.eprints-42642 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:25:59Z |
| record_format | dspace |
| spelling | usm.eprints-426422020-03-23T05:04:25Z http://eprints.usm.my/42642/ The study of glucose-6-phosphate dehydrogenase (G6PD) gene by restriction enzyme by restriction enzyme digestion in the Kelantan population Yusoff, Narazah Mohd Jamaluddin, Normah Hussin, Zabidi Azhar Mohd Ee, Choo Keng Sein, Kyaw Tun R5-920 Medicine (General) The most common diseases producing enzymopathy affecting the human population is glucose-6-phosphate dehydrogenase (G6PD) deficiency. It is estimated that about 400 million people worldwide are affected and this disease is commonest seen in the tropical and subtropical zones of the Eastern hemisphere. Molecular analysis has confirmed that the basis for G6PD deficiency is widely heterogeneous. Different mutants are responsible for the G6PD deficiency in the various parts of the world where this abnormality is prevalent. This study involved a sequential analysis whereby the blood from Malay neonates with neonatal jaundice admitted to Hospital Universiti Sains Malaysia and Kota Bharu Hospital were analyzed and polymerase chain reaction based analysis using serial multiplex primer method was done on those DNA samples. Samples that are found to be abnormal were then sequenced. Out of the 45 samples studied, 8 were found to have the Mediterranean mutation, two have the Mahidol mutation, two have Canton mutation and three have Kaiping mutation. Thus the molecular basis for the Malay neonatal jaundice in Kelantan is described with further prospect of population screening. Conference or Workshop Item NonPeerReviewed application/pdf en http://eprints.usm.my/42642/1/GP...The_Study_Of_Glucose_-_6_-_Phosphate_Dehydrogenase_%28G6PD%29_Gene_By_Restriction_Enzyme_Digestion_In_The_Kelantan_Population..OCR...pdf Yusoff, Narazah Mohd and Jamaluddin, Normah and Hussin, Zabidi Azhar Mohd and Ee, Choo Keng and Sein, Kyaw Tun The study of glucose-6-phosphate dehydrogenase (G6PD) gene by restriction enzyme by restriction enzyme digestion in the Kelantan population. In: The study of glucose-6- phosphate dehydrogenase (G6PD) gene by restriction enzyme by restriction enzyme digestion in the Kelantan population. (Submitted) |
| spellingShingle | R5-920 Medicine (General) Yusoff, Narazah Mohd Jamaluddin, Normah Hussin, Zabidi Azhar Mohd Ee, Choo Keng Sein, Kyaw Tun The study of glucose-6-phosphate dehydrogenase (G6PD) gene by restriction enzyme by restriction enzyme digestion in the Kelantan population |
| title | The study of glucose-6-phosphate dehydrogenase (G6PD) gene by restriction enzyme by restriction enzyme digestion in the Kelantan population |
| title_full | The study of glucose-6-phosphate dehydrogenase (G6PD) gene by restriction enzyme by restriction enzyme digestion in the Kelantan population |
| title_fullStr | The study of glucose-6-phosphate dehydrogenase (G6PD) gene by restriction enzyme by restriction enzyme digestion in the Kelantan population |
| title_full_unstemmed | The study of glucose-6-phosphate dehydrogenase (G6PD) gene by restriction enzyme by restriction enzyme digestion in the Kelantan population |
| title_short | The study of glucose-6-phosphate dehydrogenase (G6PD) gene by restriction enzyme by restriction enzyme digestion in the Kelantan population |
| title_sort | study of glucose 6 phosphate dehydrogenase g6pd gene by restriction enzyme by restriction enzyme digestion in the kelantan population |
| topic | R5-920 Medicine (General) |
| url | http://eprints.usm.my/42642/1/GP...The_Study_Of_Glucose_-_6_-_Phosphate_Dehydrogenase_%28G6PD%29_Gene_By_Restriction_Enzyme_Digestion_In_The_Kelantan_Population..OCR...pdf |
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