The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives
Benzyl-o-vanillin and benzimidazole nucleus serve as important pharmacophore in drug discovery as it has a significant medicinal importance. Thus we explored the anticancer activity of three compounds namely 2-(2-benzyloxy-3-methoxyphenyl)-1H-benzimidazole, 2MP, N-1-(2-benzyloxy-3-methoxybenzyl)-2-(...
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| Format: | Thesis |
| Language: | English |
| Published: |
2011
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| Online Access: | http://eprints.usm.my/42887/1/ZENA_A._ABDUL_HAMEED_AL-MUDARIS.pdf |
| _version_ | 1825834702348484608 |
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| author | Al-Mudaris, Zena A. Abdul Hameed |
| author_facet | Al-Mudaris, Zena A. Abdul Hameed |
| author_sort | Al-Mudaris, Zena A. Abdul Hameed |
| collection | USM |
| description | Benzyl-o-vanillin and benzimidazole nucleus serve as important pharmacophore in drug discovery as it has a significant medicinal importance. Thus we explored the anticancer activity of three compounds namely 2-(2-benzyloxy-3-methoxyphenyl)-1H-benzimidazole, 2MP, N-1-(2-benzyloxy-3-methoxybenzyl)-2-(2-benzyloxy-3-methoxyphenyl)-1H-benzimidazole, 2XP, and (R) and (S)-1-(2-benzyloxy-3-methoxyphenyl)-2, 2, 2-trichloroethyl benzenesulfonate, 3BS and compared their activity to 2-benzyloxy-3-methoxybenzaldehyde, (Bn1) the parent compound. 2XP and 3BS were found to be selectively cytotoxic towards U937 leukemic cell causing cell death via apoptosis by activating caspase 9 activity. |
| first_indexed | 2024-03-06T15:26:39Z |
| format | Thesis |
| id | usm.eprints-42887 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:26:39Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | usm.eprints-428872019-04-12T05:26:41Z http://eprints.usm.my/42887/ The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives Al-Mudaris, Zena A. Abdul Hameed RS1-441 Pharmacy and materia medica Benzyl-o-vanillin and benzimidazole nucleus serve as important pharmacophore in drug discovery as it has a significant medicinal importance. Thus we explored the anticancer activity of three compounds namely 2-(2-benzyloxy-3-methoxyphenyl)-1H-benzimidazole, 2MP, N-1-(2-benzyloxy-3-methoxybenzyl)-2-(2-benzyloxy-3-methoxyphenyl)-1H-benzimidazole, 2XP, and (R) and (S)-1-(2-benzyloxy-3-methoxyphenyl)-2, 2, 2-trichloroethyl benzenesulfonate, 3BS and compared their activity to 2-benzyloxy-3-methoxybenzaldehyde, (Bn1) the parent compound. 2XP and 3BS were found to be selectively cytotoxic towards U937 leukemic cell causing cell death via apoptosis by activating caspase 9 activity. 2011 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/42887/1/ZENA_A._ABDUL_HAMEED_AL-MUDARIS.pdf Al-Mudaris, Zena A. Abdul Hameed (2011) The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Al-Mudaris, Zena A. Abdul Hameed The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives |
| title | The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives |
| title_full | The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives |
| title_fullStr | The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives |
| title_full_unstemmed | The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives |
| title_short | The Study Of Anticancer Properties Of Benzyl-O-Vanillin And Its Derivatives |
| title_sort | study of anticancer properties of benzyl o vanillin and its derivatives |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/42887/1/ZENA_A._ABDUL_HAMEED_AL-MUDARIS.pdf |
| work_keys_str_mv | AT almudariszenaaabdulhameed thestudyofanticancerpropertiesofbenzylovanillinanditsderivatives AT almudariszenaaabdulhameed studyofanticancerpropertiesofbenzylovanillinanditsderivatives |