Synthesis, Characterisation And Evaluation Of Biocompatible Disulphide Cross-Linked Sodium Alginate Derivative Nanoparticles For Colon Targeted Drug Delivery
Colon specific nano-drug delivery is a challenging system for a drug to reach the colon target site without any release along the stomach and small intestines. The application of layer-by-layer (LbL) on nanoparticles surface coating has been applied to improve the colon targeted oral drug delivery o...
| Главный автор: | |
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| Формат: | Диссертация |
| Язык: | English |
| Опубликовано: |
2018
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| Online-ссылка: | http://eprints.usm.my/42901/1/ASILA_DINIE__AYUB.pdf |
| _version_ | 1825834705167056896 |
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| author | Ayub, Asila Dinie |
| author_facet | Ayub, Asila Dinie |
| author_sort | Ayub, Asila Dinie |
| collection | USM |
| description | Colon specific nano-drug delivery is a challenging system for a drug to reach the colon target site without any release along the stomach and small intestines. The application of layer-by-layer (LbL) on nanoparticles surface coating has been applied to improve the colon targeted oral drug delivery of insoluble drugs. Here, we aimed to formulate a self-assembly cysteamine-based disulphide cross-linked sodium alginate (SA) (with LbL) to improve the delivery of paclitaxel to colonic cancer cells to promote oral chemotherapy. Cysteamine was conjugated to the backbone of oxidised SA to form a core of self-assembly disulphide cross-linked nanospheres. |
| first_indexed | 2024-03-06T15:26:42Z |
| format | Thesis |
| id | usm.eprints-42901 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:26:42Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | usm.eprints-429012019-04-12T05:24:51Z http://eprints.usm.my/42901/ Synthesis, Characterisation And Evaluation Of Biocompatible Disulphide Cross-Linked Sodium Alginate Derivative Nanoparticles For Colon Targeted Drug Delivery Ayub, Asila Dinie RS1-441 Pharmacy and materia medica Colon specific nano-drug delivery is a challenging system for a drug to reach the colon target site without any release along the stomach and small intestines. The application of layer-by-layer (LbL) on nanoparticles surface coating has been applied to improve the colon targeted oral drug delivery of insoluble drugs. Here, we aimed to formulate a self-assembly cysteamine-based disulphide cross-linked sodium alginate (SA) (with LbL) to improve the delivery of paclitaxel to colonic cancer cells to promote oral chemotherapy. Cysteamine was conjugated to the backbone of oxidised SA to form a core of self-assembly disulphide cross-linked nanospheres. 2018-03 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/42901/1/ASILA_DINIE__AYUB.pdf Ayub, Asila Dinie (2018) Synthesis, Characterisation And Evaluation Of Biocompatible Disulphide Cross-Linked Sodium Alginate Derivative Nanoparticles For Colon Targeted Drug Delivery. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Ayub, Asila Dinie Synthesis, Characterisation And Evaluation Of Biocompatible Disulphide Cross-Linked Sodium Alginate Derivative Nanoparticles For Colon Targeted Drug Delivery |
| title | Synthesis, Characterisation And Evaluation Of Biocompatible Disulphide Cross-Linked Sodium Alginate Derivative Nanoparticles For Colon Targeted Drug Delivery |
| title_full | Synthesis, Characterisation And Evaluation Of Biocompatible Disulphide Cross-Linked Sodium Alginate Derivative Nanoparticles For Colon Targeted Drug Delivery |
| title_fullStr | Synthesis, Characterisation And Evaluation Of Biocompatible Disulphide Cross-Linked Sodium Alginate Derivative Nanoparticles For Colon Targeted Drug Delivery |
| title_full_unstemmed | Synthesis, Characterisation And Evaluation Of Biocompatible Disulphide Cross-Linked Sodium Alginate Derivative Nanoparticles For Colon Targeted Drug Delivery |
| title_short | Synthesis, Characterisation And Evaluation Of Biocompatible Disulphide Cross-Linked Sodium Alginate Derivative Nanoparticles For Colon Targeted Drug Delivery |
| title_sort | synthesis characterisation and evaluation of biocompatible disulphide cross linked sodium alginate derivative nanoparticles for colon targeted drug delivery |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/42901/1/ASILA_DINIE__AYUB.pdf |
| work_keys_str_mv | AT ayubasiladinie synthesischaracterisationandevaluationofbiocompatibledisulphidecrosslinkedsodiumalginatederivativenanoparticlesforcolontargeteddrugdelivery |