A Pilot Study On The A118g Mu Opioid Receptor Polymorphism Among Drug Addicts In Malaysia
Drug addiction is an important social problem in many countries. Genetic and environmental factors contribute to the predisposition of drug addiction. The opioidergic hypothesis suggests an association between genetic variations at the opioid receptor mu 1 (OPRM1) gene locus and opiate addicti...
| Main Author: | |
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| Format: | Thesis |
| Language: | English |
| Published: |
2010
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| Subjects: | |
| Online Access: | http://eprints.usm.my/42916/1/Devaki_Nagaya24.pdf |
| _version_ | 1825834708169129984 |
|---|---|
| author | Nagaya, Devaki |
| author_facet | Nagaya, Devaki |
| author_sort | Nagaya, Devaki |
| collection | USM |
| description | Drug addiction is an important social problem in many countries. Genetic and
environmental factors contribute to the predisposition of drug addiction. The
opioidergic hypothesis suggests an association between genetic variations at the
opioid receptor mu 1 (OPRM1) gene locus and opiate addiction. The present study
aim to delineate the frequency of these variants in subjects of Malaysian origin and
study their association with the phenotype of opioid dependence together with
environmental factors. A118G allele of OPRM1 gene locus was genotyped by using
allele specific PCR. The frequency of A allele and G allele was 51% and 49%
respectively for addicts and about 73% and 27% respectively for healthy volunteers.
The frequency of G allele was 1.77 fold higher in addicts by odds ratio calculation at
Cl 95%, which indicate the G allele to be strongly associated with addiction ( X2
=15.31 P< 0.0001; odds ratio 2.51; Cl 95% (1.575 – 3.994), compared to healthy
volunteers. A significant association was observed between A118G polymorphism in
Opioid receptor gene and drug addiction. The demographic data analysis showed
that the majority of the addicts grew up in the environment which makes them prone
to addiction. Hence it can be deduced that the genetic and environmental factors play
important roles in the development of addiction among Malaysian population. |
| first_indexed | 2024-03-06T15:26:45Z |
| format | Thesis |
| id | usm.eprints-42916 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:26:45Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | usm.eprints-429162019-04-12T05:26:51Z http://eprints.usm.my/42916/ A Pilot Study On The A118g Mu Opioid Receptor Polymorphism Among Drug Addicts In Malaysia Nagaya, Devaki R5-920 Medicine (General) Drug addiction is an important social problem in many countries. Genetic and environmental factors contribute to the predisposition of drug addiction. The opioidergic hypothesis suggests an association between genetic variations at the opioid receptor mu 1 (OPRM1) gene locus and opiate addiction. The present study aim to delineate the frequency of these variants in subjects of Malaysian origin and study their association with the phenotype of opioid dependence together with environmental factors. A118G allele of OPRM1 gene locus was genotyped by using allele specific PCR. The frequency of A allele and G allele was 51% and 49% respectively for addicts and about 73% and 27% respectively for healthy volunteers. The frequency of G allele was 1.77 fold higher in addicts by odds ratio calculation at Cl 95%, which indicate the G allele to be strongly associated with addiction ( X2 =15.31 P< 0.0001; odds ratio 2.51; Cl 95% (1.575 – 3.994), compared to healthy volunteers. A significant association was observed between A118G polymorphism in Opioid receptor gene and drug addiction. The demographic data analysis showed that the majority of the addicts grew up in the environment which makes them prone to addiction. Hence it can be deduced that the genetic and environmental factors play important roles in the development of addiction among Malaysian population. 2010-06 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/42916/1/Devaki_Nagaya24.pdf Nagaya, Devaki (2010) A Pilot Study On The A118g Mu Opioid Receptor Polymorphism Among Drug Addicts In Malaysia. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | R5-920 Medicine (General) Nagaya, Devaki A Pilot Study On The A118g Mu Opioid Receptor Polymorphism Among Drug Addicts In Malaysia |
| title | A Pilot Study On The A118g Mu Opioid
Receptor Polymorphism Among Drug
Addicts In Malaysia
|
| title_full | A Pilot Study On The A118g Mu Opioid
Receptor Polymorphism Among Drug
Addicts In Malaysia
|
| title_fullStr | A Pilot Study On The A118g Mu Opioid
Receptor Polymorphism Among Drug
Addicts In Malaysia
|
| title_full_unstemmed | A Pilot Study On The A118g Mu Opioid
Receptor Polymorphism Among Drug
Addicts In Malaysia
|
| title_short | A Pilot Study On The A118g Mu Opioid
Receptor Polymorphism Among Drug
Addicts In Malaysia
|
| title_sort | pilot study on the a118g mu opioid receptor polymorphism among drug addicts in malaysia |
| topic | R5-920 Medicine (General) |
| url | http://eprints.usm.my/42916/1/Devaki_Nagaya24.pdf |
| work_keys_str_mv | AT nagayadevaki apilotstudyonthea118gmuopioidreceptorpolymorphismamongdrugaddictsinmalaysia AT nagayadevaki pilotstudyonthea118gmuopioidreceptorpolymorphismamongdrugaddictsinmalaysia |