Rbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal Malay women and their relation to hormone replacement therapy.
Hiperhomosisteinemia terjadi disebabkan oleh penurunan aras kofaktor-kofaktor (vitamin B12, B6 dan folat) dan / atau akibat kekurangan keberkesanan enzim methylene tetrahydrofolate reductase (MTHFR). Keadaan ini telah dikaitkan dengan risiko kejadian ‘atherosclerosis’ yang merupakan salah satu facto...
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| Format: | Thesis |
| Language: | English |
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2011
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| Online Access: | http://eprints.usm.my/43139/1/Pages_from_RBC_PARAMETERS.pdf |
| _version_ | 1825834748450177024 |
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| author | Al Jabr, Mohamed Talal Abd Alfattah |
| author_facet | Al Jabr, Mohamed Talal Abd Alfattah |
| author_sort | Al Jabr, Mohamed Talal Abd Alfattah |
| collection | USM |
| description | Hiperhomosisteinemia terjadi disebabkan oleh penurunan aras kofaktor-kofaktor (vitamin B12, B6 dan folat) dan / atau akibat kekurangan keberkesanan enzim methylene tetrahydrofolate reductase (MTHFR). Keadaan ini telah dikaitkan dengan risiko kejadian ‘atherosclerosis’ yang merupakan salah satu factor penyumbang kepada penyakit jantung koronari di kalangan wanita menopaus. Adalah tidak di ketahui samada perubahan pada parameter-parameter sel darah merah boleh terjadi tanpa melibatkan ketidak normalan pada aras vitamin B12 dan folat di kalangan wanita menopaus yang berkaitan dengan kehadiran hiperhomosisteinemia.
Hyperhomocysteinemia occurs as a result of decreased levels of cofactors (vitamin B6, vitamin B12 and folate) and/or reduced efficiency of Methylenetetrahydrofolate reductase (MTHFR) enzyme. Hyperhomocysteinemia is an independent risk factor for atherosclerosis and may be one of the factors predisposing
for coronary heart disease (CHD) in postmenopausal women. It is not well known whether changes in red blood cells parameters can occur independently of B12 and folate abnormalities in postmenopausal women in association with hyperhomocysteinemia. |
| first_indexed | 2024-03-06T15:27:21Z |
| format | Thesis |
| id | usm.eprints-43139 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:27:21Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | usm.eprints-431392018-12-13T06:15:57Z http://eprints.usm.my/43139/ Rbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal Malay women and their relation to hormone replacement therapy. Al Jabr, Mohamed Talal Abd Alfattah R5-920 Medicine (General) Hiperhomosisteinemia terjadi disebabkan oleh penurunan aras kofaktor-kofaktor (vitamin B12, B6 dan folat) dan / atau akibat kekurangan keberkesanan enzim methylene tetrahydrofolate reductase (MTHFR). Keadaan ini telah dikaitkan dengan risiko kejadian ‘atherosclerosis’ yang merupakan salah satu factor penyumbang kepada penyakit jantung koronari di kalangan wanita menopaus. Adalah tidak di ketahui samada perubahan pada parameter-parameter sel darah merah boleh terjadi tanpa melibatkan ketidak normalan pada aras vitamin B12 dan folat di kalangan wanita menopaus yang berkaitan dengan kehadiran hiperhomosisteinemia. Hyperhomocysteinemia occurs as a result of decreased levels of cofactors (vitamin B6, vitamin B12 and folate) and/or reduced efficiency of Methylenetetrahydrofolate reductase (MTHFR) enzyme. Hyperhomocysteinemia is an independent risk factor for atherosclerosis and may be one of the factors predisposing for coronary heart disease (CHD) in postmenopausal women. It is not well known whether changes in red blood cells parameters can occur independently of B12 and folate abnormalities in postmenopausal women in association with hyperhomocysteinemia. 2011 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/43139/1/Pages_from_RBC_PARAMETERS.pdf Al Jabr, Mohamed Talal Abd Alfattah (2011) Rbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal Malay women and their relation to hormone replacement therapy. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | R5-920 Medicine (General) Al Jabr, Mohamed Talal Abd Alfattah Rbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal Malay women and their relation to hormone replacement therapy. |
| title | Rbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal Malay women and their relation to hormone replacement therapy. |
| title_full | Rbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal Malay women and their relation to hormone replacement therapy. |
| title_fullStr | Rbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal Malay women and their relation to hormone replacement therapy. |
| title_full_unstemmed | Rbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal Malay women and their relation to hormone replacement therapy. |
| title_short | Rbc parameters, vitamin b12, folate, homocysteine levels and mthfr gene polymorphism in postmenopausal Malay women and their relation to hormone replacement therapy. |
| title_sort | rbc parameters vitamin b12 folate homocysteine levels and mthfr gene polymorphism in postmenopausal malay women and their relation to hormone replacement therapy |
| topic | R5-920 Medicine (General) |
| url | http://eprints.usm.my/43139/1/Pages_from_RBC_PARAMETERS.pdf |
| work_keys_str_mv | AT aljabrmohamedtalalabdalfattah rbcparametersvitaminb12folatehomocysteinelevelsandmthfrgenepolymorphisminpostmenopausalmalaywomenandtheirrelationtohormonereplacementtherapy |