Human natural killer (NK) cell activation by luteolin from Brucea javanica leaves
There is growing interest in using natural substances from plants to potentially enhance anticancer activity. A key target in this respect is natural killer (NK) cells in order to generate an anticancerimmune response. Luteolin used in this study was derived from a local plant Brucea javanica leave...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Academic Journals
2018
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| Subjects: | |
| Online Access: | http://eprints.usm.my/43296/1/B3D352E59611.pdf |
| _version_ | 1825834773364342784 |
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| author | Ismail, Norzila Abdullah, Hasmah Seidel, Veronique Rotondo, Dino |
| author_facet | Ismail, Norzila Abdullah, Hasmah Seidel, Veronique Rotondo, Dino |
| author_sort | Ismail, Norzila |
| collection | USM |
| description | There is growing interest in using natural substances from plants to potentially enhance anticancer
activity. A key target in this respect is natural killer (NK) cells in order to generate an anticancerimmune response. Luteolin used in this study was derived from a local plant Brucea javanica leaves
extract; through a bioassay-guided fractionation. The expression of interleukin-2 (IL-2) and interferon-γ
(IFN-γ) was increased after 20 h treatment of 0.1 µM luteolin in human mixed lymphocytes, which
reflects the activation of NK cells. This was further confirmed in co-culture experiments. NK cellinduced K562 target cell death was increased in the presence of luteolin. These results show that
luteolin activates NK cells to kill target cells indicating the potential use of luteolin as an anticancer
immunostimulant. |
| first_indexed | 2024-03-06T15:27:43Z |
| format | Article |
| id | usm.eprints-43296 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:27:43Z |
| publishDate | 2018 |
| publisher | Academic Journals |
| record_format | dspace |
| spelling | usm.eprints-432962019-03-07T01:43:22Z http://eprints.usm.my/43296/ Human natural killer (NK) cell activation by luteolin from Brucea javanica leaves Ismail, Norzila Abdullah, Hasmah Seidel, Veronique Rotondo, Dino RA0421 Public health. Hygiene. Preventive Medicine There is growing interest in using natural substances from plants to potentially enhance anticancer activity. A key target in this respect is natural killer (NK) cells in order to generate an anticancerimmune response. Luteolin used in this study was derived from a local plant Brucea javanica leaves extract; through a bioassay-guided fractionation. The expression of interleukin-2 (IL-2) and interferon-γ (IFN-γ) was increased after 20 h treatment of 0.1 µM luteolin in human mixed lymphocytes, which reflects the activation of NK cells. This was further confirmed in co-culture experiments. NK cellinduced K562 target cell death was increased in the presence of luteolin. These results show that luteolin activates NK cells to kill target cells indicating the potential use of luteolin as an anticancer immunostimulant. Academic Journals 2018 Article PeerReviewed application/pdf en http://eprints.usm.my/43296/1/B3D352E59611.pdf Ismail, Norzila and Abdullah, Hasmah and Seidel, Veronique and Rotondo, Dino (2018) Human natural killer (NK) cell activation by luteolin from Brucea javanica leaves. Journal of Cancer Research and Experimental Oncology, 10 (2). pp. 10-14. ISSN 2141-2243 https://doi.org/10.5897/JCREO2012.012 |
| spellingShingle | RA0421 Public health. Hygiene. Preventive Medicine Ismail, Norzila Abdullah, Hasmah Seidel, Veronique Rotondo, Dino Human natural killer (NK) cell activation by luteolin from Brucea javanica leaves |
| title | Human natural killer (NK) cell activation by luteolin
from Brucea javanica leaves |
| title_full | Human natural killer (NK) cell activation by luteolin
from Brucea javanica leaves |
| title_fullStr | Human natural killer (NK) cell activation by luteolin
from Brucea javanica leaves |
| title_full_unstemmed | Human natural killer (NK) cell activation by luteolin
from Brucea javanica leaves |
| title_short | Human natural killer (NK) cell activation by luteolin
from Brucea javanica leaves |
| title_sort | human natural killer nk cell activation by luteolin from brucea javanica leaves |
| topic | RA0421 Public health. Hygiene. Preventive Medicine |
| url | http://eprints.usm.my/43296/1/B3D352E59611.pdf |
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