Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line
In this present study, the equimolar complexes of vancomycin, a broad-spectrum glycopeptide antibiotic with β-CD were prepared to evaluate their suitability for the development of a prolonged-release form of the antibiotic. β-CD/vancomycin complexes were prepared accordingly via freeze-drying and kn...
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| Format: | Thesis |
| Language: | English |
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2011
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| Online Access: | http://eprints.usm.my/43531/1/ZARIF%20MOHAMED%20SOFIAN.pdf |
| _version_ | 1797011026426724352 |
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| author | SOFIAN, ZARIF MOHAMED |
| author_facet | SOFIAN, ZARIF MOHAMED |
| author_sort | SOFIAN, ZARIF MOHAMED |
| collection | USM |
| description | In this present study, the equimolar complexes of vancomycin, a broad-spectrum glycopeptide antibiotic with β-CD were prepared to evaluate their suitability for the development of a prolonged-release form of the antibiotic. β-CD/vancomycin complexes were prepared accordingly via freeze-drying and kneading techniques. The formation of the complexes was confirmed through X-ray Diffractometry (XRD), Thermogravimetric Analysis (TGA), Scanning Electron Microscopy (SEM) and Fourier Transfrom Infrared Spectroscopy (FT-IR). The results obtained were all in good agreement suggesting the successive formation of the aforementioned binary systems. |
| first_indexed | 2024-03-06T15:28:17Z |
| format | Thesis |
| id | usm.eprints-43531 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:28:17Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | usm.eprints-435312019-04-12T05:26:33Z http://eprints.usm.my/43531/ Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line SOFIAN, ZARIF MOHAMED R5-920 Medicine (General) In this present study, the equimolar complexes of vancomycin, a broad-spectrum glycopeptide antibiotic with β-CD were prepared to evaluate their suitability for the development of a prolonged-release form of the antibiotic. β-CD/vancomycin complexes were prepared accordingly via freeze-drying and kneading techniques. The formation of the complexes was confirmed through X-ray Diffractometry (XRD), Thermogravimetric Analysis (TGA), Scanning Electron Microscopy (SEM) and Fourier Transfrom Infrared Spectroscopy (FT-IR). The results obtained were all in good agreement suggesting the successive formation of the aforementioned binary systems. 2011-06 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/43531/1/ZARIF%20MOHAMED%20SOFIAN.pdf SOFIAN, ZARIF MOHAMED (2011) Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | R5-920 Medicine (General) SOFIAN, ZARIF MOHAMED Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line |
| title | Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line |
| title_full | Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line |
| title_fullStr | Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line |
| title_full_unstemmed | Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line |
| title_short | Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line |
| title_sort | vancomycin and its beta cyclodextrin complex physicochemical characterization and its cytotoxicity evaluation on human glial cell line |
| topic | R5-920 Medicine (General) |
| url | http://eprints.usm.my/43531/1/ZARIF%20MOHAMED%20SOFIAN.pdf |
| work_keys_str_mv | AT sofianzarifmohamed vancomycinanditsbetacyclodextrincomplexphysicochemicalcharacterizationanditscytotoxicityevaluationonhumanglialcellline |