Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line
In this present study, the equimolar complexes of vancomycin, a broad-spectrum glycopeptide antibiotic with β-CD were prepared to evaluate their suitability for the development of a prolonged-release form of the antibiotic. β-CD/vancomycin complexes were prepared accordingly via freeze-drying and kn...
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Format: | Thesis |
Language: | English |
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2011
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Online Access: | http://eprints.usm.my/43531/1/ZARIF%20MOHAMED%20SOFIAN.pdf |
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author | SOFIAN, ZARIF MOHAMED |
author_facet | SOFIAN, ZARIF MOHAMED |
author_sort | SOFIAN, ZARIF MOHAMED |
collection | USM |
description | In this present study, the equimolar complexes of vancomycin, a broad-spectrum glycopeptide antibiotic with β-CD were prepared to evaluate their suitability for the development of a prolonged-release form of the antibiotic. β-CD/vancomycin complexes were prepared accordingly via freeze-drying and kneading techniques. The formation of the complexes was confirmed through X-ray Diffractometry (XRD), Thermogravimetric Analysis (TGA), Scanning Electron Microscopy (SEM) and Fourier Transfrom Infrared Spectroscopy (FT-IR). The results obtained were all in good agreement suggesting the successive formation of the aforementioned binary systems. |
first_indexed | 2024-03-06T15:28:17Z |
format | Thesis |
id | usm.eprints-43531 |
institution | Universiti Sains Malaysia |
language | English |
last_indexed | 2024-03-06T15:28:17Z |
publishDate | 2011 |
record_format | dspace |
spelling | usm.eprints-435312019-04-12T05:26:33Z http://eprints.usm.my/43531/ Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line SOFIAN, ZARIF MOHAMED R5-920 Medicine (General) In this present study, the equimolar complexes of vancomycin, a broad-spectrum glycopeptide antibiotic with β-CD were prepared to evaluate their suitability for the development of a prolonged-release form of the antibiotic. β-CD/vancomycin complexes were prepared accordingly via freeze-drying and kneading techniques. The formation of the complexes was confirmed through X-ray Diffractometry (XRD), Thermogravimetric Analysis (TGA), Scanning Electron Microscopy (SEM) and Fourier Transfrom Infrared Spectroscopy (FT-IR). The results obtained were all in good agreement suggesting the successive formation of the aforementioned binary systems. 2011-06 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/43531/1/ZARIF%20MOHAMED%20SOFIAN.pdf SOFIAN, ZARIF MOHAMED (2011) Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line. Masters thesis, Universiti Sains Malaysia. |
spellingShingle | R5-920 Medicine (General) SOFIAN, ZARIF MOHAMED Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line |
title | Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line |
title_full | Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line |
title_fullStr | Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line |
title_full_unstemmed | Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line |
title_short | Vancomycin And Its Beta-Cyclodextrin Complex: Physicochemical Characterization And Its Cytotoxicity Evaluation On Human Glial Cell Line |
title_sort | vancomycin and its beta cyclodextrin complex physicochemical characterization and its cytotoxicity evaluation on human glial cell line |
topic | R5-920 Medicine (General) |
url | http://eprints.usm.my/43531/1/ZARIF%20MOHAMED%20SOFIAN.pdf |
work_keys_str_mv | AT sofianzarifmohamed vancomycinanditsbetacyclodextrincomplexphysicochemicalcharacterizationanditscytotoxicityevaluationonhumanglialcellline |