| Summary: | The phytocompounds in crude solvent extracts of Pereskia bleo
leaves were identified and their cytotoxic effects on cancer cell
lines were determined. Crude extracts were obtained via
maceration and subjected to GCMS analysis. Then, each extract
was incubated with HeLa, MDA-MB-231, SW480, and NIH/3T3
cell lines for 72 h. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium
bromide assay was done to determine IC50 values
of each extract. Terpenoids, sterols, alkaloids, fatty acids and
phenolic compounds were identified from the crude extracts
of P. bleo leaves. Other compounds identified were γ-sitosterol,
β-tocopherol, and γ-tocopherol. The ethyl acetate extract had
potent cytotoxic effect against HeLa and MDA-MB-231 cancer
cells as noted by the lowest IC50 values
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