Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate
The hypothetical de novo biosynthetic pathway of endosome-specific phospholipid, bis(monoacylglycero)phosphate (BMP) from endogenous phosphatidylglycerol (PG) precursor via lysophosphatidylglycerol (LPG) intermediate had been considered. In the present study, an alternative BMP biosynthetic route fr...
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| Format: | Thesis |
| Language: | English |
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2018
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| Online Access: | http://eprints.usm.my/44253/1/LIM%20SHI%20ROU.pdf |
| _version_ | 1825834934203318272 |
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| author | Lim,, Shi Rou |
| author_facet | Lim,, Shi Rou |
| author_sort | Lim,, Shi Rou |
| collection | USM |
| description | The hypothetical de novo biosynthetic pathway of endosome-specific phospholipid, bis(monoacylglycero)phosphate (BMP) from endogenous phosphatidylglycerol (PG) precursor via lysophosphatidylglycerol (LPG) intermediate had been considered. In the present study, an alternative BMP biosynthetic route from PG via acylphosphatidylglycerol (AcPG) intermediate was proposed. A considerable amount of AcPG was found present in and outside the RAW 264.7 cells during 24 hours of incubation with exogenous PG. A transacylase is required to transfer an acyl chain from a PG donor to a PG acceptor, transforming the acceptor PG into AcPG and the donor PG into LPG. |
| first_indexed | 2024-03-06T15:30:08Z |
| format | Thesis |
| id | usm.eprints-44253 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:30:08Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | usm.eprints-442532019-05-06T00:55:09Z http://eprints.usm.my/44253/ Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate Lim,, Shi Rou RS1-441 Pharmacy and materia medica The hypothetical de novo biosynthetic pathway of endosome-specific phospholipid, bis(monoacylglycero)phosphate (BMP) from endogenous phosphatidylglycerol (PG) precursor via lysophosphatidylglycerol (LPG) intermediate had been considered. In the present study, an alternative BMP biosynthetic route from PG via acylphosphatidylglycerol (AcPG) intermediate was proposed. A considerable amount of AcPG was found present in and outside the RAW 264.7 cells during 24 hours of incubation with exogenous PG. A transacylase is required to transfer an acyl chain from a PG donor to a PG acceptor, transforming the acceptor PG into AcPG and the donor PG into LPG. 2018-03 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/44253/1/LIM%20SHI%20ROU.pdf Lim,, Shi Rou (2018) Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Lim,, Shi Rou Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate |
| title | Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate |
| title_full | Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate |
| title_fullStr | Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate |
| title_full_unstemmed | Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate |
| title_short | Biosynthesis Of Endosome-Specific Lipid Bis(Monoacylglycero)Phosphate |
| title_sort | biosynthesis of endosome specific lipid bis monoacylglycero phosphate |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/44253/1/LIM%20SHI%20ROU.pdf |
| work_keys_str_mv | AT limshirou biosynthesisofendosomespecificlipidbismonoacylglycerophosphate |