Insight into potential mechanisms of hypobaric hypoxia–induced learning and memory deficit – Lessons from rat studies
Impairment of memory is one of the most frequently reported symptoms during sudden hypoxia exposure in human. Cortical atrophy has been linked to the impaired memory function and is suggested to occur with chronic high-altitude exposure. However, the precise molecular mechanism(s) of hypoxia-induc...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publications
2017
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| Subjects: | |
| Online Access: | http://eprints.usm.my/44405/1/Insight%20into%20potential%20mechanisms%20of%20hypobaric%20hypoxia%E2%80%93induced%20learning%20and%20memory%20deficit.pdf |
| Summary: | Impairment of memory is one of the most frequently reported symptoms during sudden hypoxia exposure in
human. Cortical atrophy has been linked to the impaired memory function and is suggested to occur with
chronic high-altitude exposure. However, the precise molecular mechanism(s) of hypoxia-induced memory
impairment remains an enigma. In this work, we review hypoxia-induced learning and memory deficit in human
and rat studies. Based on data from rat studies using different protocols of continuous hypoxia, we try to elicit
potential mechanisms of hypobaric hypoxia–induced memory deficit. |
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