Ultrasound features in the diagnosis of biliary atresia
Objective: To assess the role of ultrasound (US) in the diagnosis of biliary atresia. Methodology: Fasting infants with conjugated hyperbilirubinemia were subjected for US examination in Hospital Sultanah Bahiyah, Kedah. The patients were grouped into biliary atresia (BA) and non-biliary atresia...
| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
2017
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/44632/1/Dr.%20Sim%20See%20Khim-24%20pages.pdf |
| _version_ | 1825835003644215296 |
|---|---|
| author | Khim, Sim See |
| author_facet | Khim, Sim See |
| author_sort | Khim, Sim See |
| collection | USM |
| description | Objective: To assess the role of ultrasound (US) in the diagnosis of biliary atresia.
Methodology: Fasting infants with conjugated hyperbilirubinemia were subjected for US
examination in Hospital Sultanah Bahiyah, Kedah. The patients were grouped into biliary atresia
(BA) and non-biliary atresia (non-BA) based on the surgical findings and clinical follow up. The
following features were recorded: tri-angular cord sign, gall bladder morphology, liver size, and
echotexture, splenic size, hepatic artery size, hepatic artery to portal vein ratio, presence of a
common bile duct, and presence of subcapsular flow on colour Doppler. Sensitivity, specificity,
positive and negative predictive values were calculated for each US variable. BA and non-BA
groups were compared by using the Fisher exact test for categorical variables and an unpaired t
test for continues variable.
Results: A total of 82 infants were included in the study; 42 had surgically confirmed BA and 40
had other documented causes of neonatal jaundice. Nine US features showed a significant different
between BA and non-BA group. Ultrasound able to correctly classified 82 infants into BA and
non-BA group with 98% accuracy.
Conclusions: BA can be diagnosed with US from other cause of conjugated hyperbilirubinemia
in 98% of patients if multiple US features are carefully evaluated. These ultrasound variables may
serve as independent predictors of BA. |
| first_indexed | 2024-03-06T15:31:11Z |
| format | Thesis |
| id | usm.eprints-44632 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:31:11Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | usm.eprints-446322020-10-22T03:03:14Z http://eprints.usm.my/44632/ Ultrasound features in the diagnosis of biliary atresia Khim, Sim See R Medicine (General) Objective: To assess the role of ultrasound (US) in the diagnosis of biliary atresia. Methodology: Fasting infants with conjugated hyperbilirubinemia were subjected for US examination in Hospital Sultanah Bahiyah, Kedah. The patients were grouped into biliary atresia (BA) and non-biliary atresia (non-BA) based on the surgical findings and clinical follow up. The following features were recorded: tri-angular cord sign, gall bladder morphology, liver size, and echotexture, splenic size, hepatic artery size, hepatic artery to portal vein ratio, presence of a common bile duct, and presence of subcapsular flow on colour Doppler. Sensitivity, specificity, positive and negative predictive values were calculated for each US variable. BA and non-BA groups were compared by using the Fisher exact test for categorical variables and an unpaired t test for continues variable. Results: A total of 82 infants were included in the study; 42 had surgically confirmed BA and 40 had other documented causes of neonatal jaundice. Nine US features showed a significant different between BA and non-BA group. Ultrasound able to correctly classified 82 infants into BA and non-BA group with 98% accuracy. Conclusions: BA can be diagnosed with US from other cause of conjugated hyperbilirubinemia in 98% of patients if multiple US features are carefully evaluated. These ultrasound variables may serve as independent predictors of BA. 2017 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/44632/1/Dr.%20Sim%20See%20Khim-24%20pages.pdf Khim, Sim See (2017) Ultrasound features in the diagnosis of biliary atresia. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | R Medicine (General) Khim, Sim See Ultrasound features in the diagnosis of biliary atresia |
| title | Ultrasound features in the diagnosis of biliary atresia |
| title_full | Ultrasound features in the diagnosis of biliary atresia |
| title_fullStr | Ultrasound features in the diagnosis of biliary atresia |
| title_full_unstemmed | Ultrasound features in the diagnosis of biliary atresia |
| title_short | Ultrasound features in the diagnosis of biliary atresia |
| title_sort | ultrasound features in the diagnosis of biliary atresia |
| topic | R Medicine (General) |
| url | http://eprints.usm.my/44632/1/Dr.%20Sim%20See%20Khim-24%20pages.pdf |
| work_keys_str_mv | AT khimsimsee ultrasoundfeaturesinthediagnosisofbiliaryatresia |