Voltage Clamp Electrophysiology Screening Of Selected Compounds From Zizyphus Mauritiana And Myristica Fragrans On Specific GABA Receptors
This study focused on the effects of the methanol crude extract of Zizyphus mauritiana leaves and the essential oil of the mesocarp of Myristica fragrans on the function of GABA (A) receptors. Both crude and essential oil were tested on the Xenopus laevis oocytes that comprised of GABA (A) receptors...
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| Format: | Thesis |
| Language: | English |
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2012
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| Online Access: | http://eprints.usm.my/44777/1/AHMAD%20TARMIZI.pdf |
| _version_ | 1825835030996320256 |
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| author | Che Has, Ahmad Tarmizi |
| author_facet | Che Has, Ahmad Tarmizi |
| author_sort | Che Has, Ahmad Tarmizi |
| collection | USM |
| description | This study focused on the effects of the methanol crude extract of Zizyphus mauritiana leaves and the essential oil of the mesocarp of Myristica fragrans on the function of GABA (A) receptors. Both crude and essential oil were tested on the Xenopus laevis oocytes that comprised of GABA (A) receptors α1β2γ2s subtype. An automated fast perfusion system that applied the two microelectrodes voltage clamp measurement technique at EC5-10 of GABA was used. GABA or gamma-aminobutyric acid is the major inhibitory neurotransmitter in the mammalian central nervous system and involves in the balance between excitation and inhibition in the neuronal cells. |
| first_indexed | 2024-03-06T15:31:36Z |
| format | Thesis |
| id | usm.eprints-44777 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:31:36Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | usm.eprints-447772019-07-01T02:17:29Z http://eprints.usm.my/44777/ Voltage Clamp Electrophysiology Screening Of Selected Compounds From Zizyphus Mauritiana And Myristica Fragrans On Specific GABA Receptors Che Has, Ahmad Tarmizi R5-920 Medicine (General) This study focused on the effects of the methanol crude extract of Zizyphus mauritiana leaves and the essential oil of the mesocarp of Myristica fragrans on the function of GABA (A) receptors. Both crude and essential oil were tested on the Xenopus laevis oocytes that comprised of GABA (A) receptors α1β2γ2s subtype. An automated fast perfusion system that applied the two microelectrodes voltage clamp measurement technique at EC5-10 of GABA was used. GABA or gamma-aminobutyric acid is the major inhibitory neurotransmitter in the mammalian central nervous system and involves in the balance between excitation and inhibition in the neuronal cells. 2012-05 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/44777/1/AHMAD%20TARMIZI.pdf Che Has, Ahmad Tarmizi (2012) Voltage Clamp Electrophysiology Screening Of Selected Compounds From Zizyphus Mauritiana And Myristica Fragrans On Specific GABA Receptors. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | R5-920 Medicine (General) Che Has, Ahmad Tarmizi Voltage Clamp Electrophysiology Screening Of Selected Compounds From Zizyphus Mauritiana And Myristica Fragrans On Specific GABA Receptors |
| title | Voltage Clamp Electrophysiology Screening Of Selected Compounds From Zizyphus Mauritiana And Myristica Fragrans On Specific GABA Receptors |
| title_full | Voltage Clamp Electrophysiology Screening Of Selected Compounds From Zizyphus Mauritiana And Myristica Fragrans On Specific GABA Receptors |
| title_fullStr | Voltage Clamp Electrophysiology Screening Of Selected Compounds From Zizyphus Mauritiana And Myristica Fragrans On Specific GABA Receptors |
| title_full_unstemmed | Voltage Clamp Electrophysiology Screening Of Selected Compounds From Zizyphus Mauritiana And Myristica Fragrans On Specific GABA Receptors |
| title_short | Voltage Clamp Electrophysiology Screening Of Selected Compounds From Zizyphus Mauritiana And Myristica Fragrans On Specific GABA Receptors |
| title_sort | voltage clamp electrophysiology screening of selected compounds from zizyphus mauritiana and myristica fragrans on specific gaba receptors |
| topic | R5-920 Medicine (General) |
| url | http://eprints.usm.my/44777/1/AHMAD%20TARMIZI.pdf |
| work_keys_str_mv | AT chehasahmadtarmizi voltageclampelectrophysiologyscreeningofselectedcompoundsfromzizyphusmauritianaandmyristicafragransonspecificgabareceptors |