Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid
The effect of co-solvents and bases have been investigated in Candida rugosa lipase (CRL)-catalyzed hydrolysis of (R,S)-2-ethoxyethyl ibuprofen ester in biphasic water-isooctane medium. A high log P and low pKa values of co-solvent has reduced the reaction rate for the production of (S)-ibuprofen ac...
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| Format: | Thesis |
| Language: | English |
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2012
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| Online Access: | http://eprints.usm.my/44801/1/FADZIL%20NOOR%20BIN%20GONAWAN.pdf |
| _version_ | 1825835035562868736 |
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| author | Gonawan, Fadzil Noor |
| author_facet | Gonawan, Fadzil Noor |
| author_sort | Gonawan, Fadzil Noor |
| collection | USM |
| description | The effect of co-solvents and bases have been investigated in Candida rugosa lipase (CRL)-catalyzed hydrolysis of (R,S)-2-ethoxyethyl ibuprofen ester in biphasic water-isooctane medium. A high log P and low pKa values of co-solvent has reduced the reaction rate for the production of (S)-ibuprofen acid. Moreover, the hydrolysis process shows an optimum performance at only 2% (v/v) dimethyl sulfoxide (DMSO) and at the reaction temperature of 30°C. The addition of 2% (v/v) DMSO has increased the conversion of substrate and further increase in the concentration of DMSO has resulted in a low initial reaction rate and conversion of substrate, however gives a high enantiomeric excess of the product (eeP). |
| first_indexed | 2024-03-06T15:31:41Z |
| format | Thesis |
| id | usm.eprints-44801 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:31:41Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | usm.eprints-448012019-07-02T01:19:25Z http://eprints.usm.my/44801/ Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid Gonawan, Fadzil Noor TP1-1185 Chemical technology The effect of co-solvents and bases have been investigated in Candida rugosa lipase (CRL)-catalyzed hydrolysis of (R,S)-2-ethoxyethyl ibuprofen ester in biphasic water-isooctane medium. A high log P and low pKa values of co-solvent has reduced the reaction rate for the production of (S)-ibuprofen acid. Moreover, the hydrolysis process shows an optimum performance at only 2% (v/v) dimethyl sulfoxide (DMSO) and at the reaction temperature of 30°C. The addition of 2% (v/v) DMSO has increased the conversion of substrate and further increase in the concentration of DMSO has resulted in a low initial reaction rate and conversion of substrate, however gives a high enantiomeric excess of the product (eeP). 2012-06 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/44801/1/FADZIL%20NOOR%20BIN%20GONAWAN.pdf Gonawan, Fadzil Noor (2012) Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | TP1-1185 Chemical technology Gonawan, Fadzil Noor Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid |
| title | Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid |
| title_full | Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid |
| title_fullStr | Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid |
| title_full_unstemmed | Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid |
| title_short | Kinetics And Modelling For The Production Of (S)-Ibuprofen Acid |
| title_sort | kinetics and modelling for the production of s ibuprofen acid |
| topic | TP1-1185 Chemical technology |
| url | http://eprints.usm.my/44801/1/FADZIL%20NOOR%20BIN%20GONAWAN.pdf |
| work_keys_str_mv | AT gonawanfadzilnoor kineticsandmodellingfortheproductionofsibuprofenacid |