A Study Of The Genetic Variations In N-Terminus, C-Terminus And Promoter Of Rb1 Gene Among Retinoblastoma Patients In Malaysia
Retinoblastoma (RB) is the most common primary intraocular tumor affecting mainly children under five years of age, with a prevalence of 1 in 15 000 to 20 000 live births. Retinoblastoma is divided into hereditary and sporadic types. It is caused by mutations or changes in RB1 gene, a tumor suppress...
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| Format: | Thesis |
| Language: | English |
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2012
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| Online Access: | http://eprints.usm.my/44906/1/SITI%20NORULHUDA%20BT%20HAJI%20DRAMAN%20%40%20HASHIM.pdf |
| _version_ | 1797011277429604352 |
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| author | Hashim, Siti Norulhuda Haji Draman @ |
| author_facet | Hashim, Siti Norulhuda Haji Draman @ |
| author_sort | Hashim, Siti Norulhuda Haji Draman @ |
| collection | USM |
| description | Retinoblastoma (RB) is the most common primary intraocular tumor affecting mainly children under five years of age, with a prevalence of 1 in 15 000 to 20 000 live births. Retinoblastoma is divided into hereditary and sporadic types. It is caused by mutations or changes in RB1 gene, a tumor suppressor gene. The aim of this study is to detect mutations in N-terminus, C-terminus and promoter region of RB1 gene in retinoblastoma patients in Malaysia, as well as its association with staging and laterality of the patients. A total of 68 children with sporadic RB from Hospital Universiti Sains Malaysia (HUSM), Hospital Kuala Lumpur (HKL) and University Malaya Medical Centre (UMMC) and 68 healthy ethnic-matched controls were recruited. |
| first_indexed | 2024-03-06T15:31:59Z |
| format | Thesis |
| id | usm.eprints-44906 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:31:59Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | usm.eprints-449062019-07-09T01:17:17Z http://eprints.usm.my/44906/ A Study Of The Genetic Variations In N-Terminus, C-Terminus And Promoter Of Rb1 Gene Among Retinoblastoma Patients In Malaysia Hashim, Siti Norulhuda Haji Draman @ R5-920 Medicine (General) Retinoblastoma (RB) is the most common primary intraocular tumor affecting mainly children under five years of age, with a prevalence of 1 in 15 000 to 20 000 live births. Retinoblastoma is divided into hereditary and sporadic types. It is caused by mutations or changes in RB1 gene, a tumor suppressor gene. The aim of this study is to detect mutations in N-terminus, C-terminus and promoter region of RB1 gene in retinoblastoma patients in Malaysia, as well as its association with staging and laterality of the patients. A total of 68 children with sporadic RB from Hospital Universiti Sains Malaysia (HUSM), Hospital Kuala Lumpur (HKL) and University Malaya Medical Centre (UMMC) and 68 healthy ethnic-matched controls were recruited. 2012-05 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/44906/1/SITI%20NORULHUDA%20BT%20HAJI%20DRAMAN%20%40%20HASHIM.pdf Hashim, Siti Norulhuda Haji Draman @ (2012) A Study Of The Genetic Variations In N-Terminus, C-Terminus And Promoter Of Rb1 Gene Among Retinoblastoma Patients In Malaysia. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | R5-920 Medicine (General) Hashim, Siti Norulhuda Haji Draman @ A Study Of The Genetic Variations In N-Terminus, C-Terminus And Promoter Of Rb1 Gene Among Retinoblastoma Patients In Malaysia |
| title | A Study Of The Genetic Variations In N-Terminus, C-Terminus And Promoter Of Rb1 Gene Among Retinoblastoma Patients In Malaysia |
| title_full | A Study Of The Genetic Variations In N-Terminus, C-Terminus And Promoter Of Rb1 Gene Among Retinoblastoma Patients In Malaysia |
| title_fullStr | A Study Of The Genetic Variations In N-Terminus, C-Terminus And Promoter Of Rb1 Gene Among Retinoblastoma Patients In Malaysia |
| title_full_unstemmed | A Study Of The Genetic Variations In N-Terminus, C-Terminus And Promoter Of Rb1 Gene Among Retinoblastoma Patients In Malaysia |
| title_short | A Study Of The Genetic Variations In N-Terminus, C-Terminus And Promoter Of Rb1 Gene Among Retinoblastoma Patients In Malaysia |
| title_sort | study of the genetic variations in n terminus c terminus and promoter of rb1 gene among retinoblastoma patients in malaysia |
| topic | R5-920 Medicine (General) |
| url | http://eprints.usm.my/44906/1/SITI%20NORULHUDA%20BT%20HAJI%20DRAMAN%20%40%20HASHIM.pdf |
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