Molecular Cytogenetics Of Myelodysplastic Syndrome – Hospital Based Study
Myelodysplastic Syndrome (MDS) is a haematological condition characterised by hypercellular bone marrow and low peripheral blood counts. The objectives of this study were to identify chromosomal aberration using conventional cytogenetics and array comparative genomic hybridisation (array-CGH) in MDS...
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| Format: | Thesis |
| Language: | English |
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2014
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| Online Access: | http://eprints.usm.my/44991/1/ASMIDA%20ISA.pdf |
| _version_ | 1825835071316164608 |
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| author | Isa, Asmida |
| author_facet | Isa, Asmida |
| author_sort | Isa, Asmida |
| collection | USM |
| description | Myelodysplastic Syndrome (MDS) is a haematological condition characterised by hypercellular bone marrow and low peripheral blood counts. The objectives of this study were to identify chromosomal aberration using conventional cytogenetics and array comparative genomic hybridisation (array-CGH) in MDS patients and correlate with its’ haematological findings. A total of 8 patients were recruited. Cytogenetic mresults revealed six normal karyotypes, a karyotype with structural abnormalities
(del(5)(q13q33) and a karyotype with complex rearrangement (t(1;11), t(2;11), del(4p), del(5p), del(9p)). By array-CGH technique, known cytogenetic aberrations, complex chromosome aberrations and rare/cryptic aberrations (<5 Mb) were detected. |
| first_indexed | 2024-03-06T15:32:13Z |
| format | Thesis |
| id | usm.eprints-44991 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:32:13Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | usm.eprints-449912019-07-22T02:52:28Z http://eprints.usm.my/44991/ Molecular Cytogenetics Of Myelodysplastic Syndrome – Hospital Based Study Isa, Asmida R735-854 Medical education. Medical schools. Research Myelodysplastic Syndrome (MDS) is a haematological condition characterised by hypercellular bone marrow and low peripheral blood counts. The objectives of this study were to identify chromosomal aberration using conventional cytogenetics and array comparative genomic hybridisation (array-CGH) in MDS patients and correlate with its’ haematological findings. A total of 8 patients were recruited. Cytogenetic mresults revealed six normal karyotypes, a karyotype with structural abnormalities (del(5)(q13q33) and a karyotype with complex rearrangement (t(1;11), t(2;11), del(4p), del(5p), del(9p)). By array-CGH technique, known cytogenetic aberrations, complex chromosome aberrations and rare/cryptic aberrations (<5 Mb) were detected. 2014-07 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/44991/1/ASMIDA%20ISA.pdf Isa, Asmida (2014) Molecular Cytogenetics Of Myelodysplastic Syndrome – Hospital Based Study. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | R735-854 Medical education. Medical schools. Research Isa, Asmida Molecular Cytogenetics Of Myelodysplastic Syndrome – Hospital Based Study |
| title | Molecular Cytogenetics Of Myelodysplastic Syndrome – Hospital Based Study |
| title_full | Molecular Cytogenetics Of Myelodysplastic Syndrome – Hospital Based Study |
| title_fullStr | Molecular Cytogenetics Of Myelodysplastic Syndrome – Hospital Based Study |
| title_full_unstemmed | Molecular Cytogenetics Of Myelodysplastic Syndrome – Hospital Based Study |
| title_short | Molecular Cytogenetics Of Myelodysplastic Syndrome – Hospital Based Study |
| title_sort | molecular cytogenetics of myelodysplastic syndrome hospital based study |
| topic | R735-854 Medical education. Medical schools. Research |
| url | http://eprints.usm.my/44991/1/ASMIDA%20ISA.pdf |
| work_keys_str_mv | AT isaasmida molecularcytogeneticsofmyelodysplasticsyndromehospitalbasedstudy |