Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans
Candida albicans is an opportunistic pathogen that causes candidiasis in human. Metabolic pathways have been recently explored as potential antimicrobial targets, for example glyoxylate cycle that enables the C. albicans to servive nutrient-limited niches. Glyoxylate cycle and its key enzymes would...
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| Format: | Thesis |
| Language: | English |
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2014
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| Online Access: | http://eprints.usm.my/44992/1/CHEAH%20HONG%20LEONG.pdf |
| _version_ | 1825835071509102592 |
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| author | Cheah, Hong Leong |
| author_facet | Cheah, Hong Leong |
| author_sort | Cheah, Hong Leong |
| collection | USM |
| description | Candida albicans is an opportunistic pathogen that causes candidiasis in human. Metabolic pathways have been recently explored as potential antimicrobial targets, for example glyoxylate cycle that enables the C. albicans to servive nutrient-limited niches. Glyoxylate cycle and its key enzymes would be an attractive antifungal drug target for C. albicans. In this study, an alternative cell-based screening approach that better reflect the physiological environment in host system was employed to identify lead compounds that inhibit the glyoxylate cycle. |
| first_indexed | 2024-03-06T15:32:13Z |
| format | Thesis |
| id | usm.eprints-44992 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:32:13Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | usm.eprints-449922019-07-22T02:57:10Z http://eprints.usm.my/44992/ Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans Cheah, Hong Leong R735-854 Medical education. Medical schools. Research Candida albicans is an opportunistic pathogen that causes candidiasis in human. Metabolic pathways have been recently explored as potential antimicrobial targets, for example glyoxylate cycle that enables the C. albicans to servive nutrient-limited niches. Glyoxylate cycle and its key enzymes would be an attractive antifungal drug target for C. albicans. In this study, an alternative cell-based screening approach that better reflect the physiological environment in host system was employed to identify lead compounds that inhibit the glyoxylate cycle. 2014-06 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/44992/1/CHEAH%20HONG%20LEONG.pdf Cheah, Hong Leong (2014) Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | R735-854 Medical education. Medical schools. Research Cheah, Hong Leong Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans |
| title | Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans |
| title_full | Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans |
| title_fullStr | Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans |
| title_full_unstemmed | Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans |
| title_short | Screening And Characterisation Of Inhibitors For Glyoxylate Cycle ICL Enzyme Activity In Candida Albicans |
| title_sort | screening and characterisation of inhibitors for glyoxylate cycle icl enzyme activity in candida albicans |
| topic | R735-854 Medical education. Medical schools. Research |
| url | http://eprints.usm.my/44992/1/CHEAH%20HONG%20LEONG.pdf |
| work_keys_str_mv | AT cheahhongleong screeningandcharacterisationofinhibitorsforglyoxylatecycleiclenzymeactivityincandidaalbicans |