The Chemo-Sensitisation Effect Of Curcumin Against Low Dose Cisplatin On Non-Small Cell Lung Cancer (NSCLC) Stem Cells
Cancer stem cells (CSCs) represent a small subpopulation within a tumour that possesses the stem-like properties but are also initiating resistance towards cytotoxic agent which contribute to cancer relapse. A natural compound such as curcumin that contains high polyphenol has been found to possess...
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| Format: | Thesis |
| Language: | English |
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2018
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| Online Access: | http://eprints.usm.my/45013/1/NAZILAH%20ABDUL%20SATAR.pdf |
| _version_ | 1825835074942140416 |
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| author | Nazilah, Abdul Satar |
| author_facet | Nazilah, Abdul Satar |
| author_sort | Nazilah, Abdul Satar |
| collection | USM |
| description | Cancer stem cells (CSCs) represent a small subpopulation within a tumour that possesses the stem-like properties but are also initiating resistance towards cytotoxic agent which contribute to cancer relapse. A natural compound such as curcumin that contains high polyphenol has been found to possess chemo-sensitivity effect with an ability to sensitise the CSCs to the cytotoxic agents such as cisplatin. Therefore, the present study was designed to investigate the efficiency of curcumin as a chemo-sensitiser in lung CSCs and to analyse its inhibitory effect on CSCs activity using A549 and H2170 cell lines that belong to non-small cell lung cancer (NSCLC). |
| first_indexed | 2024-03-06T15:32:16Z |
| format | Thesis |
| id | usm.eprints-45013 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:32:16Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | usm.eprints-450132019-07-23T01:40:22Z http://eprints.usm.my/45013/ The Chemo-Sensitisation Effect Of Curcumin Against Low Dose Cisplatin On Non-Small Cell Lung Cancer (NSCLC) Stem Cells Nazilah, Abdul Satar R735-854 Medical education. Medical schools. Research Cancer stem cells (CSCs) represent a small subpopulation within a tumour that possesses the stem-like properties but are also initiating resistance towards cytotoxic agent which contribute to cancer relapse. A natural compound such as curcumin that contains high polyphenol has been found to possess chemo-sensitivity effect with an ability to sensitise the CSCs to the cytotoxic agents such as cisplatin. Therefore, the present study was designed to investigate the efficiency of curcumin as a chemo-sensitiser in lung CSCs and to analyse its inhibitory effect on CSCs activity using A549 and H2170 cell lines that belong to non-small cell lung cancer (NSCLC). 2018-09 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/45013/1/NAZILAH%20ABDUL%20SATAR.pdf Nazilah, Abdul Satar (2018) The Chemo-Sensitisation Effect Of Curcumin Against Low Dose Cisplatin On Non-Small Cell Lung Cancer (NSCLC) Stem Cells. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | R735-854 Medical education. Medical schools. Research Nazilah, Abdul Satar The Chemo-Sensitisation Effect Of Curcumin Against Low Dose Cisplatin On Non-Small Cell Lung Cancer (NSCLC) Stem Cells |
| title | The Chemo-Sensitisation Effect Of Curcumin Against Low Dose Cisplatin On Non-Small Cell Lung Cancer (NSCLC) Stem Cells |
| title_full | The Chemo-Sensitisation Effect Of Curcumin Against Low Dose Cisplatin On Non-Small Cell Lung Cancer (NSCLC) Stem Cells |
| title_fullStr | The Chemo-Sensitisation Effect Of Curcumin Against Low Dose Cisplatin On Non-Small Cell Lung Cancer (NSCLC) Stem Cells |
| title_full_unstemmed | The Chemo-Sensitisation Effect Of Curcumin Against Low Dose Cisplatin On Non-Small Cell Lung Cancer (NSCLC) Stem Cells |
| title_short | The Chemo-Sensitisation Effect Of Curcumin Against Low Dose Cisplatin On Non-Small Cell Lung Cancer (NSCLC) Stem Cells |
| title_sort | chemo sensitisation effect of curcumin against low dose cisplatin on non small cell lung cancer nsclc stem cells |
| topic | R735-854 Medical education. Medical schools. Research |
| url | http://eprints.usm.my/45013/1/NAZILAH%20ABDUL%20SATAR.pdf |
| work_keys_str_mv | AT nazilahabdulsatar thechemosensitisationeffectofcurcuminagainstlowdosecisplatinonnonsmallcelllungcancernsclcstemcells AT nazilahabdulsatar chemosensitisationeffectofcurcuminagainstlowdosecisplatinonnonsmallcelllungcancernsclcstemcells |