Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein
The capsid protein plays seminal roles in both early and late stages of the HIV replication cycle. Hence, HIV-1 capsid protein is considered an important target for developing novel drugs to treat HIV/AIDS. Capsid molecule (CA)-targeting peptide inhibitors (CAP-1, CAI and NYAD-1) have been reported...
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| Format: | Thesis |
| Language: | English |
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2015
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| Online Access: | http://eprints.usm.my/45074/1/TEOW%20SIN%20YEANG.pdf |
| _version_ | 1825835085485572096 |
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| author | Teow, Sin Yeang |
| author_facet | Teow, Sin Yeang |
| author_sort | Teow, Sin Yeang |
| collection | USM |
| description | The capsid protein plays seminal roles in both early and late stages of the HIV replication cycle. Hence, HIV-1 capsid protein is considered an important target for developing novel drugs to treat HIV/AIDS. Capsid molecule (CA)-targeting peptide inhibitors (CAP-1, CAI and NYAD-1) have been reported to disrupt the capsid protein functions in HIV-infected cells. However, the peptides are less stable in the blood, thus resulting in rapid clearance from the system and they can exhibit off-target activities. Monoclonal antibodies (MAbs) on the other hand, are stable and highly specific molecule, |
| first_indexed | 2024-03-06T15:32:26Z |
| format | Thesis |
| id | usm.eprints-45074 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:32:26Z |
| publishDate | 2015 |
| record_format | dspace |
| spelling | usm.eprints-450742019-07-26T01:21:06Z http://eprints.usm.my/45074/ Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein Teow, Sin Yeang R735-854 Medical education. Medical schools. Research The capsid protein plays seminal roles in both early and late stages of the HIV replication cycle. Hence, HIV-1 capsid protein is considered an important target for developing novel drugs to treat HIV/AIDS. Capsid molecule (CA)-targeting peptide inhibitors (CAP-1, CAI and NYAD-1) have been reported to disrupt the capsid protein functions in HIV-infected cells. However, the peptides are less stable in the blood, thus resulting in rapid clearance from the system and they can exhibit off-target activities. Monoclonal antibodies (MAbs) on the other hand, are stable and highly specific molecule, 2015-08 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/45074/1/TEOW%20SIN%20YEANG.pdf Teow, Sin Yeang (2015) Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | R735-854 Medical education. Medical schools. Research Teow, Sin Yeang Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein |
| title | Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein |
| title_full | Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein |
| title_fullStr | Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein |
| title_full_unstemmed | Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein |
| title_short | Cell-Penetrating Antibodies For Targeting HIV-1 P24 Capsid Protein |
| title_sort | cell penetrating antibodies for targeting hiv 1 p24 capsid protein |
| topic | R735-854 Medical education. Medical schools. Research |
| url | http://eprints.usm.my/45074/1/TEOW%20SIN%20YEANG.pdf |
| work_keys_str_mv | AT teowsinyeang cellpenetratingantibodiesfortargetinghiv1p24capsidprotein |