A prevalence study of platelet alloantibodies in multiply transfused thrombocytopenic patients in HUSM
BACKGROUND: Multiply transfused patients are frequently subjected to platelet alloimmunization. These platelet alloantibodies produced can result in refractoriness to platelet transfusion. STUDY DESIGN AND METHODS: Ninety five thrombocytopenic (platelet count <1 00 x 1 09/1) and multilply tra...
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| Format: | Article |
| Language: | English |
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Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
2004
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| Online Access: | http://eprints.usm.my/45343/1/GP...A%20Prevalenca%20Study%20Of%20Platelet%20Alloantibodies%20In%20Miltiply%20Transfused%20Rhrombocytopenic%20Patients%20In%20HUSM...2004...-24%20pages.pdf |
| _version_ | 1797011358788616192 |
|---|---|
| author | Mahmood, Wan Haslindawani Wan |
| author_facet | Mahmood, Wan Haslindawani Wan |
| author_sort | Mahmood, Wan Haslindawani Wan |
| collection | USM |
| description | BACKGROUND: Multiply transfused patients are frequently subjected to platelet
alloimmunization. These platelet alloantibodies produced can result in refractoriness to
platelet transfusion.
STUDY DESIGN AND METHODS: Ninety five thrombocytopenic (platelet count
<1 00 x 1 09/1) and multilply transfused (more than 2 times transfusion of any blood
component with last transfusion more than 2 weeks prior to the study) patients were
recruited prospectively. The blood samples were tested using a Solid Phase system
(Capture P).
RESULTS: There were 45 males (47.4%) and 50 females (52.6%) recruited with ages
from 3 to 90 years. The frequency of transfusions ranged from 10-168. Seven patients
(7.4%) were detected to have platelet alloantibodies, predominantly anti-HPA-5b in 4
patients (4.2%). Three of them (3.2%) showed a non-specific pattern. Six patients (6.3%)
had received packed cells less than 20 units and another 1 (1.1%) received more than 20
units of packed cells. Four patients (4.2%) received platelet transfusion of less than 20
units and another 3 patients (3.2%) received more than 20 unit platelets.
CONCLUSION: The study may have future implications for the selection of platelet
donors for alloimmunized recipients in HUSM. |
| first_indexed | 2024-03-06T15:33:11Z |
| format | Article |
| id | usm.eprints-45343 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:33:11Z |
| publishDate | 2004 |
| publisher | Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia |
| record_format | dspace |
| spelling | usm.eprints-453432019-09-08T08:27:56Z http://eprints.usm.my/45343/ A prevalence study of platelet alloantibodies in multiply transfused thrombocytopenic patients in HUSM Mahmood, Wan Haslindawani Wan R Medicine BACKGROUND: Multiply transfused patients are frequently subjected to platelet alloimmunization. These platelet alloantibodies produced can result in refractoriness to platelet transfusion. STUDY DESIGN AND METHODS: Ninety five thrombocytopenic (platelet count <1 00 x 1 09/1) and multilply transfused (more than 2 times transfusion of any blood component with last transfusion more than 2 weeks prior to the study) patients were recruited prospectively. The blood samples were tested using a Solid Phase system (Capture P). RESULTS: There were 45 males (47.4%) and 50 females (52.6%) recruited with ages from 3 to 90 years. The frequency of transfusions ranged from 10-168. Seven patients (7.4%) were detected to have platelet alloantibodies, predominantly anti-HPA-5b in 4 patients (4.2%). Three of them (3.2%) showed a non-specific pattern. Six patients (6.3%) had received packed cells less than 20 units and another 1 (1.1%) received more than 20 units of packed cells. Four patients (4.2%) received platelet transfusion of less than 20 units and another 3 patients (3.2%) received more than 20 unit platelets. CONCLUSION: The study may have future implications for the selection of platelet donors for alloimmunized recipients in HUSM. Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2004 Article NonPeerReviewed application/pdf en http://eprints.usm.my/45343/1/GP...A%20Prevalenca%20Study%20Of%20Platelet%20Alloantibodies%20In%20Miltiply%20Transfused%20Rhrombocytopenic%20Patients%20In%20HUSM...2004...-24%20pages.pdf Mahmood, Wan Haslindawani Wan (2004) A prevalence study of platelet alloantibodies in multiply transfused thrombocytopenic patients in HUSM. A prevalence study of platelet alloantibodies in multiply transfused thrombocytopenic patients in HUSM. (Submitted) |
| spellingShingle | R Medicine Mahmood, Wan Haslindawani Wan A prevalence study of platelet alloantibodies in multiply transfused thrombocytopenic patients in HUSM |
| title | A prevalence study of platelet alloantibodies in multiply
transfused thrombocytopenic patients in HUSM |
| title_full | A prevalence study of platelet alloantibodies in multiply
transfused thrombocytopenic patients in HUSM |
| title_fullStr | A prevalence study of platelet alloantibodies in multiply
transfused thrombocytopenic patients in HUSM |
| title_full_unstemmed | A prevalence study of platelet alloantibodies in multiply
transfused thrombocytopenic patients in HUSM |
| title_short | A prevalence study of platelet alloantibodies in multiply
transfused thrombocytopenic patients in HUSM |
| title_sort | prevalence study of platelet alloantibodies in multiply transfused thrombocytopenic patients in husm |
| topic | R Medicine |
| url | http://eprints.usm.my/45343/1/GP...A%20Prevalenca%20Study%20Of%20Platelet%20Alloantibodies%20In%20Miltiply%20Transfused%20Rhrombocytopenic%20Patients%20In%20HUSM...2004...-24%20pages.pdf |
| work_keys_str_mv | AT mahmoodwanhaslindawaniwan aprevalencestudyofplateletalloantibodiesinmultiplytransfusedthrombocytopenicpatientsinhusm AT mahmoodwanhaslindawaniwan prevalencestudyofplateletalloantibodiesinmultiplytransfusedthrombocytopenicpatientsinhusm |