Pegylated Phospholipid Nanomicelles Containing Budesonide Or Beclimethasone Dipropionate For Pulmonary Delivery
The aims of the present study were to formulate and evaluate nanomicelles containing poorly water soluble corticosteroids, budesonide (BUD) or beclomethasone dipropionate (BDP) for pulmonary delivery using PEGylated polymers (PEG5000-DSPE and PEG2000-DSPE). All the sterically stabilized phosphol...
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| Format: | Thesis |
| Language: | English |
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2011
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| Online Access: | http://eprints.usm.my/46297/1/Mohanad%20Naji%20Sahib_HJ.pdf |
| _version_ | 1797011547350892544 |
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| author | Sahib, Mohanad Naji |
| author_facet | Sahib, Mohanad Naji |
| author_sort | Sahib, Mohanad Naji |
| collection | USM |
| description | The aims of the present study were to formulate and evaluate nanomicelles
containing poorly water soluble corticosteroids, budesonide (BUD) or
beclomethasone dipropionate (BDP) for pulmonary delivery using PEGylated
polymers (PEG5000-DSPE and PEG2000-DSPE).
All the sterically stabilized phospholipid nanomicelles (SSMs) were successfully
prepared using a co-precipitation and reconstitution method. The SSMs were
characterised by different physicochemical methods. There were significant
differences between the maximum solubilisation tendencies of PEG5000-DSPE and
PEG2000-DSPE for BUD, which were approximately 605.71±6.38 and 646.27±4.93
μg/ml, respectively. The maximum solubilisation tendencies of PEG5000-DSPE and
PEG2000-DSPE for BDP were approximately 209.65±7.74 and 210.01±5.28,
respectively. These results showed that PEGylated polymers had greater tendencies
to solubilise BUD than BDP. The mean particle sizes at maximum solubilisation of
BUD:PEG2000-DSPE (15.97±1.91 nm) and BDP:PEG2000-DSPE (15.44±1.66 nm)
were smaller than BUD:PEG5000-DSPE (20.45±1.65 nm) and BDP:PEG5000-DSPE
(19.99±0.98 nm). Blank SSMs of PEG5000-DSPE were successfully lyophilised at a
concentration of about 5 mM, while 10 mM of PEG2000-DSPE was needed for
lyophilisation. |
| first_indexed | 2024-03-06T15:35:54Z |
| format | Thesis |
| id | usm.eprints-46297 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:35:54Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | usm.eprints-462972020-02-20T07:25:43Z http://eprints.usm.my/46297/ Pegylated Phospholipid Nanomicelles Containing Budesonide Or Beclimethasone Dipropionate For Pulmonary Delivery Sahib, Mohanad Naji RS1-441 Pharmacy and materia medica The aims of the present study were to formulate and evaluate nanomicelles containing poorly water soluble corticosteroids, budesonide (BUD) or beclomethasone dipropionate (BDP) for pulmonary delivery using PEGylated polymers (PEG5000-DSPE and PEG2000-DSPE). All the sterically stabilized phospholipid nanomicelles (SSMs) were successfully prepared using a co-precipitation and reconstitution method. The SSMs were characterised by different physicochemical methods. There were significant differences between the maximum solubilisation tendencies of PEG5000-DSPE and PEG2000-DSPE for BUD, which were approximately 605.71±6.38 and 646.27±4.93 μg/ml, respectively. The maximum solubilisation tendencies of PEG5000-DSPE and PEG2000-DSPE for BDP were approximately 209.65±7.74 and 210.01±5.28, respectively. These results showed that PEGylated polymers had greater tendencies to solubilise BUD than BDP. The mean particle sizes at maximum solubilisation of BUD:PEG2000-DSPE (15.97±1.91 nm) and BDP:PEG2000-DSPE (15.44±1.66 nm) were smaller than BUD:PEG5000-DSPE (20.45±1.65 nm) and BDP:PEG5000-DSPE (19.99±0.98 nm). Blank SSMs of PEG5000-DSPE were successfully lyophilised at a concentration of about 5 mM, while 10 mM of PEG2000-DSPE was needed for lyophilisation. 2011 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/46297/1/Mohanad%20Naji%20Sahib_HJ.pdf Sahib, Mohanad Naji (2011) Pegylated Phospholipid Nanomicelles Containing Budesonide Or Beclimethasone Dipropionate For Pulmonary Delivery. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Sahib, Mohanad Naji Pegylated Phospholipid Nanomicelles Containing Budesonide Or Beclimethasone Dipropionate For Pulmonary Delivery |
| title | Pegylated Phospholipid Nanomicelles Containing Budesonide Or Beclimethasone Dipropionate For Pulmonary Delivery |
| title_full | Pegylated Phospholipid Nanomicelles Containing Budesonide Or Beclimethasone Dipropionate For Pulmonary Delivery |
| title_fullStr | Pegylated Phospholipid Nanomicelles Containing Budesonide Or Beclimethasone Dipropionate For Pulmonary Delivery |
| title_full_unstemmed | Pegylated Phospholipid Nanomicelles Containing Budesonide Or Beclimethasone Dipropionate For Pulmonary Delivery |
| title_short | Pegylated Phospholipid Nanomicelles Containing Budesonide Or Beclimethasone Dipropionate For Pulmonary Delivery |
| title_sort | pegylated phospholipid nanomicelles containing budesonide or beclimethasone dipropionate for pulmonary delivery |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/46297/1/Mohanad%20Naji%20Sahib_HJ.pdf |
| work_keys_str_mv | AT sahibmohanadnaji pegylatedphospholipidnanomicellescontainingbudesonideorbeclimethasonedipropionateforpulmonarydelivery |