In vivo study of a locally manufactured hydroxyapatite-based material as bone replacement material
The objective of the study is to evaluate the osteoconductive, osteoinductive and biocompatibility properties of a locally produced dense hydroxyapatite (HA) as bone replacement material in mandibles. The study was carried out on 8 New Zealand White rabbits. Defects were created in the mandible o...
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| Format: | Article |
| Language: | English |
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Pusat Pengajian Sains Pergigian Universiti Sains Malaysia
2004
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| Online Access: | http://eprints.usm.my/46364/1/GP...In%20Vivo%20Study%20Of%20A%20Locally%20Manufactured%20Hydroxyapayite%20Based%20Material%20As%20Bone%20Replacement%20Material...2005...-OCR.pdf |
| _version_ | 1797011560053342208 |
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| author | Razak, Noor Hayati Abdul Samsudin, Ab. Rani Omar, Nor Shamsuria |
| author_facet | Razak, Noor Hayati Abdul Samsudin, Ab. Rani Omar, Nor Shamsuria |
| author_sort | Razak, Noor Hayati Abdul |
| collection | USM |
| description | The objective of the study is to evaluate the osteoconductive, osteoinductive and
biocompatibility properties of a locally produced dense hydroxyapatite (HA) as
bone replacement material in mandibles. The study was carried out on 8 New
Zealand White rabbits. Defects were created in the mandible of a rabbit model
whereby the right side was implanted with HA while the left side was left empty to
act as a control. The dense HA blocks with the pore size of < 5J.1m promotes bone
ingrowth as early as 4 weeks when viewed by the topographic method. Both the
implant and control sites were evaluated clinically and histologically at 4, 12, 20, 22
weeks interval. Enhancement of osteoconduction was evident by the presence of
abundant capillaries, perivascular tissue and osteoprogenitor cells of the host
accounting for the new bone filling the gap and remodelling taking place. This
study demonstrated that the dense HA exhibits excellent biocompatibility as noted
by the complete absence of reactive cells. HA also promotes osteoconduction. It
appears that this locally manufactured HA has the potential to be a valuable
replacement material for maxillofacial reconstructive surgery and orthopaedic
surgery. |
| first_indexed | 2024-03-06T15:36:05Z |
| format | Article |
| id | usm.eprints-46364 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:36:05Z |
| publishDate | 2004 |
| publisher | Pusat Pengajian Sains Pergigian Universiti Sains Malaysia |
| record_format | dspace |
| spelling | usm.eprints-463642020-02-27T04:01:06Z http://eprints.usm.my/46364/ In vivo study of a locally manufactured hydroxyapatite-based material as bone replacement material Razak, Noor Hayati Abdul Samsudin, Ab. Rani Omar, Nor Shamsuria RK Dentistry The objective of the study is to evaluate the osteoconductive, osteoinductive and biocompatibility properties of a locally produced dense hydroxyapatite (HA) as bone replacement material in mandibles. The study was carried out on 8 New Zealand White rabbits. Defects were created in the mandible of a rabbit model whereby the right side was implanted with HA while the left side was left empty to act as a control. The dense HA blocks with the pore size of < 5J.1m promotes bone ingrowth as early as 4 weeks when viewed by the topographic method. Both the implant and control sites were evaluated clinically and histologically at 4, 12, 20, 22 weeks interval. Enhancement of osteoconduction was evident by the presence of abundant capillaries, perivascular tissue and osteoprogenitor cells of the host accounting for the new bone filling the gap and remodelling taking place. This study demonstrated that the dense HA exhibits excellent biocompatibility as noted by the complete absence of reactive cells. HA also promotes osteoconduction. It appears that this locally manufactured HA has the potential to be a valuable replacement material for maxillofacial reconstructive surgery and orthopaedic surgery. Pusat Pengajian Sains Pergigian Universiti Sains Malaysia 2004 Article NonPeerReviewed application/pdf en http://eprints.usm.my/46364/1/GP...In%20Vivo%20Study%20Of%20A%20Locally%20Manufactured%20Hydroxyapayite%20Based%20Material%20As%20Bone%20Replacement%20Material...2005...-OCR.pdf Razak, Noor Hayati Abdul and Samsudin, Ab. Rani and Omar, Nor Shamsuria (2004) In vivo study of a locally manufactured hydroxyapatite-based material as bone replacement material. In vivo study of a locally manufactured hydroxyapatite-based material as bone replacement material. (Submitted) |
| spellingShingle | RK Dentistry Razak, Noor Hayati Abdul Samsudin, Ab. Rani Omar, Nor Shamsuria In vivo study of a locally manufactured hydroxyapatite-based material as bone replacement material |
| title | In vivo study of a locally
manufactured hydroxyapatite-based material as bone
replacement material |
| title_full | In vivo study of a locally
manufactured hydroxyapatite-based material as bone
replacement material |
| title_fullStr | In vivo study of a locally
manufactured hydroxyapatite-based material as bone
replacement material |
| title_full_unstemmed | In vivo study of a locally
manufactured hydroxyapatite-based material as bone
replacement material |
| title_short | In vivo study of a locally
manufactured hydroxyapatite-based material as bone
replacement material |
| title_sort | in vivo study of a locally manufactured hydroxyapatite based material as bone replacement material |
| topic | RK Dentistry |
| url | http://eprints.usm.my/46364/1/GP...In%20Vivo%20Study%20Of%20A%20Locally%20Manufactured%20Hydroxyapayite%20Based%20Material%20As%20Bone%20Replacement%20Material...2005...-OCR.pdf |
| work_keys_str_mv | AT razaknoorhayatiabdul invivostudyofalocallymanufacturedhydroxyapatitebasedmaterialasbonereplacementmaterial AT samsudinabrani invivostudyofalocallymanufacturedhydroxyapatitebasedmaterialasbonereplacementmaterial AT omarnorshamsuria invivostudyofalocallymanufacturedhydroxyapatitebasedmaterialasbonereplacementmaterial |