Detection of epstein-barr virus in lower gastrointestinal tract lymphomas

Background: Many studies in the literature have shown that Epstein-Barr virus (EBV) is associated with several human lymphoid and epithelial malignancies. However, the prevalence of EBV in non-Hodgkin lymphoma (NHL) of the lower gastrointestinal (Gl) tract has not been fully elucidated. Aim: The...

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Main Authors: Yunos, Asmah M., ]aafar, Hasnan, ldris, Fauziah M., Kaur, Gurjeet
Format: Article
Language:English
Published: Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2006
Subjects:
Online Access:http://eprints.usm.my/47185/1/GP...Compilation%20Of%20Scientific%20Publication...2006...mka..-24%20pages.pdf
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author Yunos, Asmah M.
]aafar, Hasnan
ldris, Fauziah M.
Kaur, Gurjeet
author_facet Yunos, Asmah M.
]aafar, Hasnan
ldris, Fauziah M.
Kaur, Gurjeet
author_sort Yunos, Asmah M.
collection USM
description Background: Many studies in the literature have shown that Epstein-Barr virus (EBV) is associated with several human lymphoid and epithelial malignancies. However, the prevalence of EBV in non-Hodgkin lymphoma (NHL) of the lower gastrointestinal (Gl) tract has not been fully elucidated. Aim: The aim of this study was to determine the presence and distribution of EBV in formalin-fixed paraffin-embedded tissue samples obtained from 18 Malaysian patients diagnosed with NHL of the lower GI tract. Methods: The GI tract lymphoma tissue samples analyzed for the presence of EBV were divided into the following groups: NHL of the smalJ intestine (seven cases); NHL of the ileocecum {ten cases); and NHL of the rectum {one case). The presence ofEBV-encoded RNA (EBER) in all of the above tissue samples was tested for using conventional in situ hybridization technology. · Results: Two of 18 cases (11.1%) ofNin.. of the lowerGI tract demonstrated positive signals forEBVIEBER. In the first positive case, EBV lEBER signals were located in lymphoma cells in the serosa layer of the small intestine. In the second EBVIEBER-positive case, EBVIEBER signals were detected in diffuse B-celllymphoma of the ileocecum. Conclusion: These findings demonstrate a rare association between EBV and lower GI tract lymphomas in this group of Malaysian patients.
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spelling usm.eprints-471852020-09-09T08:52:16Z http://eprints.usm.my/47185/ Detection of epstein-barr virus in lower gastrointestinal tract lymphomas Yunos, Asmah M. ]aafar, Hasnan ldris, Fauziah M. Kaur, Gurjeet RC799-869 Diseases of the digestive system. Gastroenterology Background: Many studies in the literature have shown that Epstein-Barr virus (EBV) is associated with several human lymphoid and epithelial malignancies. However, the prevalence of EBV in non-Hodgkin lymphoma (NHL) of the lower gastrointestinal (Gl) tract has not been fully elucidated. Aim: The aim of this study was to determine the presence and distribution of EBV in formalin-fixed paraffin-embedded tissue samples obtained from 18 Malaysian patients diagnosed with NHL of the lower GI tract. Methods: The GI tract lymphoma tissue samples analyzed for the presence of EBV were divided into the following groups: NHL of the smalJ intestine (seven cases); NHL of the ileocecum {ten cases); and NHL of the rectum {one case). The presence ofEBV-encoded RNA (EBER) in all of the above tissue samples was tested for using conventional in situ hybridization technology. · Results: Two of 18 cases (11.1%) ofNin.. of the lowerGI tract demonstrated positive signals forEBVIEBER. In the first positive case, EBV lEBER signals were located in lymphoma cells in the serosa layer of the small intestine. In the second EBVIEBER-positive case, EBVIEBER signals were detected in diffuse B-celllymphoma of the ileocecum. Conclusion: These findings demonstrate a rare association between EBV and lower GI tract lymphomas in this group of Malaysian patients. Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2006 Article NonPeerReviewed application/pdf en http://eprints.usm.my/47185/1/GP...Compilation%20Of%20Scientific%20Publication...2006...mka..-24%20pages.pdf Yunos, Asmah M. and ]aafar, Hasnan and ldris, Fauziah M. and Kaur, Gurjeet (2006) Detection of epstein-barr virus in lower gastrointestinal tract lymphomas. Detection of epstein-barr virus in lower gastrointestinal tract lymphomas. (Submitted)
spellingShingle RC799-869 Diseases of the digestive system. Gastroenterology
Yunos, Asmah M.
]aafar, Hasnan
ldris, Fauziah M.
Kaur, Gurjeet
Detection of epstein-barr virus in lower gastrointestinal tract lymphomas
title Detection of epstein-barr virus in lower gastrointestinal tract lymphomas
title_full Detection of epstein-barr virus in lower gastrointestinal tract lymphomas
title_fullStr Detection of epstein-barr virus in lower gastrointestinal tract lymphomas
title_full_unstemmed Detection of epstein-barr virus in lower gastrointestinal tract lymphomas
title_short Detection of epstein-barr virus in lower gastrointestinal tract lymphomas
title_sort detection of epstein barr virus in lower gastrointestinal tract lymphomas
topic RC799-869 Diseases of the digestive system. Gastroenterology
url http://eprints.usm.my/47185/1/GP...Compilation%20Of%20Scientific%20Publication...2006...mka..-24%20pages.pdf
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