Detection of epstein-barr virus in lower gastrointestinal tract lymphomas
Background: Many studies in the literature have shown that Epstein-Barr virus (EBV) is associated with several human lymphoid and epithelial malignancies. However, the prevalence of EBV in non-Hodgkin lymphoma (NHL) of the lower gastrointestinal (Gl) tract has not been fully elucidated. Aim: The...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
2006
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/47185/1/GP...Compilation%20Of%20Scientific%20Publication...2006...mka..-24%20pages.pdf |
| _version_ | 1825905696938393600 |
|---|---|
| author | Yunos, Asmah M. ]aafar, Hasnan ldris, Fauziah M. Kaur, Gurjeet |
| author_facet | Yunos, Asmah M. ]aafar, Hasnan ldris, Fauziah M. Kaur, Gurjeet |
| author_sort | Yunos, Asmah M. |
| collection | USM |
| description | Background: Many studies in the literature have shown that Epstein-Barr virus (EBV) is associated with several
human lymphoid and epithelial malignancies. However, the prevalence of EBV in non-Hodgkin lymphoma
(NHL) of the lower gastrointestinal (Gl) tract has not been fully elucidated.
Aim: The aim of this study was to determine the presence and distribution of EBV in formalin-fixed
paraffin-embedded tissue samples obtained from 18 Malaysian patients diagnosed with NHL of the lower GI
tract.
Methods: The GI tract lymphoma tissue samples analyzed for the presence of EBV were divided into the
following groups: NHL of the smalJ intestine (seven cases); NHL of the ileocecum {ten cases); and NHL of the
rectum {one case). The presence ofEBV-encoded RNA (EBER) in all of the above tissue samples was tested for
using conventional in situ hybridization technology. ·
Results: Two of 18 cases (11.1%) ofNin.. of the lowerGI tract demonstrated positive signals forEBVIEBER. In
the first positive case, EBV lEBER signals were located in lymphoma cells in the serosa layer of the small
intestine. In the second EBVIEBER-positive case, EBVIEBER signals were detected in diffuse B-celllymphoma
of the ileocecum.
Conclusion: These findings demonstrate a rare association between EBV and lower GI tract lymphomas in this
group of Malaysian patients. |
| first_indexed | 2024-03-06T15:38:18Z |
| format | Article |
| id | usm.eprints-47185 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:38:18Z |
| publishDate | 2006 |
| publisher | Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia |
| record_format | dspace |
| spelling | usm.eprints-471852020-09-09T08:52:16Z http://eprints.usm.my/47185/ Detection of epstein-barr virus in lower gastrointestinal tract lymphomas Yunos, Asmah M. ]aafar, Hasnan ldris, Fauziah M. Kaur, Gurjeet RC799-869 Diseases of the digestive system. Gastroenterology Background: Many studies in the literature have shown that Epstein-Barr virus (EBV) is associated with several human lymphoid and epithelial malignancies. However, the prevalence of EBV in non-Hodgkin lymphoma (NHL) of the lower gastrointestinal (Gl) tract has not been fully elucidated. Aim: The aim of this study was to determine the presence and distribution of EBV in formalin-fixed paraffin-embedded tissue samples obtained from 18 Malaysian patients diagnosed with NHL of the lower GI tract. Methods: The GI tract lymphoma tissue samples analyzed for the presence of EBV were divided into the following groups: NHL of the smalJ intestine (seven cases); NHL of the ileocecum {ten cases); and NHL of the rectum {one case). The presence ofEBV-encoded RNA (EBER) in all of the above tissue samples was tested for using conventional in situ hybridization technology. · Results: Two of 18 cases (11.1%) ofNin.. of the lowerGI tract demonstrated positive signals forEBVIEBER. In the first positive case, EBV lEBER signals were located in lymphoma cells in the serosa layer of the small intestine. In the second EBVIEBER-positive case, EBVIEBER signals were detected in diffuse B-celllymphoma of the ileocecum. Conclusion: These findings demonstrate a rare association between EBV and lower GI tract lymphomas in this group of Malaysian patients. Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2006 Article NonPeerReviewed application/pdf en http://eprints.usm.my/47185/1/GP...Compilation%20Of%20Scientific%20Publication...2006...mka..-24%20pages.pdf Yunos, Asmah M. and ]aafar, Hasnan and ldris, Fauziah M. and Kaur, Gurjeet (2006) Detection of epstein-barr virus in lower gastrointestinal tract lymphomas. Detection of epstein-barr virus in lower gastrointestinal tract lymphomas. (Submitted) |
| spellingShingle | RC799-869 Diseases of the digestive system. Gastroenterology Yunos, Asmah M. ]aafar, Hasnan ldris, Fauziah M. Kaur, Gurjeet Detection of epstein-barr virus in lower gastrointestinal tract lymphomas |
| title | Detection of epstein-barr virus in lower
gastrointestinal tract lymphomas |
| title_full | Detection of epstein-barr virus in lower
gastrointestinal tract lymphomas |
| title_fullStr | Detection of epstein-barr virus in lower
gastrointestinal tract lymphomas |
| title_full_unstemmed | Detection of epstein-barr virus in lower
gastrointestinal tract lymphomas |
| title_short | Detection of epstein-barr virus in lower
gastrointestinal tract lymphomas |
| title_sort | detection of epstein barr virus in lower gastrointestinal tract lymphomas |
| topic | RC799-869 Diseases of the digestive system. Gastroenterology |
| url | http://eprints.usm.my/47185/1/GP...Compilation%20Of%20Scientific%20Publication...2006...mka..-24%20pages.pdf |
| work_keys_str_mv | AT yunosasmahm detectionofepsteinbarrvirusinlowergastrointestinaltractlymphomas AT aafarhasnan detectionofepsteinbarrvirusinlowergastrointestinaltractlymphomas AT ldrisfauziahm detectionofepsteinbarrvirusinlowergastrointestinaltractlymphomas AT kaurgurjeet detectionofepsteinbarrvirusinlowergastrointestinaltractlymphomas |