Genetic basis of supernumerary tooth
Teeth are highly mineralised tissues located at the entrance of the alimentary tract in both invertebrates and vertebrates [1]. Teeth are the elements of dermal skeleton that are present in a wide range of jawed vertebrates [2]. Though the main function of teeth is in chewing food, yet, they a...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Pusat Pengajian Sains Pergigian, Universiti Sains Malaysia
2019
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| Subjects: | |
| Online Access: | http://eprints.usm.my/47754/1/published%20manuscript%20genetic%20basis%20of%20SPN%20tooth-OCR.pdf |
| _version_ | 1797011823642279936 |
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| author | Kannan, Suhailiza Yasmin, Sarliza |
| author_facet | Kannan, Suhailiza Yasmin, Sarliza |
| author_sort | Kannan, Suhailiza |
| collection | USM |
| description | Teeth are highly mineralised tissues located at
the entrance of the alimentary tract in both
invertebrates and vertebrates [1]. Teeth are the
elements of dermal skeleton that are present in a
wide range of jawed vertebrates [2]. Though the
main function of teeth is in chewing food, yet,
they are also associated with defence, display of
dominance as well as in the vocalisation in
humans [3]. The human dentition comprises 20
teeth in the primary dentition and 32 in the
permanent dentition [4, 5, 6]. Tooth agenesis
denotes missing tooth/teeth as a result of
developmental failure that results in decreased
number of normal complement in human dentition
[7]. Conversely, a supernumerary tooth denotes
any tooth or odontogenic structure that is formed
from a tooth germ resulting in more than the
usual number of any given region in a dental arch
[4, 5, 6].
A search was made in databases using the
keywords ‘supernumerary teeth, mouse, humans,
genetics’. The articles collected were subjected to
a systematic review to analyse the genetic basis
of supernumerary teeth. Supernumerary teeth
can be seen in many genetic disorders; but they
are more common in syndromes like Gardner’s
syndrome, cleft lip and palate and cleidocranial
dysplasia (CCD) and less commonly seen in
Fabry disease, Nance-Horan syndrome, Ellis-Van
Creveld syndrome, Rubinstein-Taybi syndrome
and trichorhinophalangeal syndrome [8]. Genetic
entities that represent supernumerary teeth as a
salient finding have been attributed to autosomal
dominant inheritance, X chromosome inheritance
and to both the inheritance patterns based on
their locus heterogeneity [9]. Also, there are many
reports supporting the theory of familial tendency
to supernumerary teeth which were more evident
in the relatives of the affected individuals [10].
Moreover, Seema Gupta and Praveen Kumar
reported based on their study that in 8.6% of
cases, there was a history of the same
abnormality observed in other members of the
family, which ascertained the hereditary nature of
hyperdontia to occur [11]. |
| first_indexed | 2024-03-06T15:39:57Z |
| format | Article |
| id | usm.eprints-47754 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:39:57Z |
| publishDate | 2019 |
| publisher | Pusat Pengajian Sains Pergigian, Universiti Sains Malaysia |
| record_format | dspace |
| spelling | usm.eprints-477542020-10-26T03:33:27Z http://eprints.usm.my/47754/ Genetic basis of supernumerary tooth Kannan, Suhailiza Yasmin, Sarliza RK Dentistry Teeth are highly mineralised tissues located at the entrance of the alimentary tract in both invertebrates and vertebrates [1]. Teeth are the elements of dermal skeleton that are present in a wide range of jawed vertebrates [2]. Though the main function of teeth is in chewing food, yet, they are also associated with defence, display of dominance as well as in the vocalisation in humans [3]. The human dentition comprises 20 teeth in the primary dentition and 32 in the permanent dentition [4, 5, 6]. Tooth agenesis denotes missing tooth/teeth as a result of developmental failure that results in decreased number of normal complement in human dentition [7]. Conversely, a supernumerary tooth denotes any tooth or odontogenic structure that is formed from a tooth germ resulting in more than the usual number of any given region in a dental arch [4, 5, 6]. A search was made in databases using the keywords ‘supernumerary teeth, mouse, humans, genetics’. The articles collected were subjected to a systematic review to analyse the genetic basis of supernumerary teeth. Supernumerary teeth can be seen in many genetic disorders; but they are more common in syndromes like Gardner’s syndrome, cleft lip and palate and cleidocranial dysplasia (CCD) and less commonly seen in Fabry disease, Nance-Horan syndrome, Ellis-Van Creveld syndrome, Rubinstein-Taybi syndrome and trichorhinophalangeal syndrome [8]. Genetic entities that represent supernumerary teeth as a salient finding have been attributed to autosomal dominant inheritance, X chromosome inheritance and to both the inheritance patterns based on their locus heterogeneity [9]. Also, there are many reports supporting the theory of familial tendency to supernumerary teeth which were more evident in the relatives of the affected individuals [10]. Moreover, Seema Gupta and Praveen Kumar reported based on their study that in 8.6% of cases, there was a history of the same abnormality observed in other members of the family, which ascertained the hereditary nature of hyperdontia to occur [11]. Pusat Pengajian Sains Pergigian, Universiti Sains Malaysia 2019 Article NonPeerReviewed application/pdf en http://eprints.usm.my/47754/1/published%20manuscript%20genetic%20basis%20of%20SPN%20tooth-OCR.pdf Kannan, Suhailiza and Yasmin, Sarliza (2019) Genetic basis of supernumerary tooth. Genetic basis of supernumerary tooth. (Submitted) |
| spellingShingle | RK Dentistry Kannan, Suhailiza Yasmin, Sarliza Genetic basis of supernumerary tooth |
| title | Genetic basis of supernumerary tooth |
| title_full | Genetic basis of supernumerary tooth |
| title_fullStr | Genetic basis of supernumerary tooth |
| title_full_unstemmed | Genetic basis of supernumerary tooth |
| title_short | Genetic basis of supernumerary tooth |
| title_sort | genetic basis of supernumerary tooth |
| topic | RK Dentistry |
| url | http://eprints.usm.my/47754/1/published%20manuscript%20genetic%20basis%20of%20SPN%20tooth-OCR.pdf |
| work_keys_str_mv | AT kannansuhailiza geneticbasisofsupernumerarytooth AT yasminsarliza geneticbasisofsupernumerarytooth |