Detecting schizophrenia in the prodromal phase: screening of genetic risk relatives
Background: To screen and detect individuals at ultra high risk (UHR) for psychosis and evaluate the efficacy of a screening program. Methods: This a two-stage study involving relatives of patients with schizophrenia. The nonfirst degree relatives were additionally screened with the Screening Que...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia
2009
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| Subjects: | |
| Online Access: | http://eprints.usm.my/48690/1/DR.%20MOHD%20RAZALI%20SALLEH-OCR1.pdf |
| _version_ | 1797012025215287296 |
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| author | Salleh, Mohd Razali Othman, Zahiruddin Alwi, Muhd Najib Mohd Yassin, Mohd Azhar Mohd |
| author_facet | Salleh, Mohd Razali Othman, Zahiruddin Alwi, Muhd Najib Mohd Yassin, Mohd Azhar Mohd |
| author_sort | Salleh, Mohd Razali |
| collection | USM |
| description | Background: To screen and detect individuals at ultra high risk (UHR) for psychosis and
evaluate the efficacy of a screening program.
Methods: This a two-stage study involving relatives of patients with schizophrenia. The nonfirst
degree relatives were additionally screened with the Screening Questionnaires ( SQ),
besides the GHQ-12 and GAF in the first stage. All the positive subjects will proceed to the
second stage assessment.
Results: Sixty four (14.2 %) of 450 selective relatives were positive in the first stage. In the
second stage, only 14 (3.1 %) were positive (UHR subject). The sensitivity of the SQ (67%)
was much better than the GHQ (29%), but the specificity was not much difference. The
d~t~ction rate of UHR individuals was higher in non-first degree relatives.
Implications: Screening of genetic risk relatives is feasible. The high detection rate among
non-first degree relatives is contributed by the addition of the SQ. The GHQ is not suitable
for screening in early psychosis. |
| first_indexed | 2024-03-06T15:42:36Z |
| format | Article |
| id | usm.eprints-48690 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:42:36Z |
| publishDate | 2009 |
| publisher | Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia |
| record_format | dspace |
| spelling | usm.eprints-486902021-03-25T07:21:27Z http://eprints.usm.my/48690/ Detecting schizophrenia in the prodromal phase: screening of genetic risk relatives Salleh, Mohd Razali Othman, Zahiruddin Alwi, Muhd Najib Mohd Yassin, Mohd Azhar Mohd R Medicine Background: To screen and detect individuals at ultra high risk (UHR) for psychosis and evaluate the efficacy of a screening program. Methods: This a two-stage study involving relatives of patients with schizophrenia. The nonfirst degree relatives were additionally screened with the Screening Questionnaires ( SQ), besides the GHQ-12 and GAF in the first stage. All the positive subjects will proceed to the second stage assessment. Results: Sixty four (14.2 %) of 450 selective relatives were positive in the first stage. In the second stage, only 14 (3.1 %) were positive (UHR subject). The sensitivity of the SQ (67%) was much better than the GHQ (29%), but the specificity was not much difference. The d~t~ction rate of UHR individuals was higher in non-first degree relatives. Implications: Screening of genetic risk relatives is feasible. The high detection rate among non-first degree relatives is contributed by the addition of the SQ. The GHQ is not suitable for screening in early psychosis. Pusat Pengajian Sains Perubatan, Universiti Sains Malaysia 2009 Article NonPeerReviewed application/pdf en http://eprints.usm.my/48690/1/DR.%20MOHD%20RAZALI%20SALLEH-OCR1.pdf Salleh, Mohd Razali and Othman, Zahiruddin and Alwi, Muhd Najib Mohd and Yassin, Mohd Azhar Mohd (2009) Detecting schizophrenia in the prodromal phase: screening of genetic risk relatives. Detecting schizophrenia in the prodromal phase: screening of genetic risk relatives. (Submitted) |
| spellingShingle | R Medicine Salleh, Mohd Razali Othman, Zahiruddin Alwi, Muhd Najib Mohd Yassin, Mohd Azhar Mohd Detecting schizophrenia in the prodromal phase: screening of genetic risk relatives |
| title | Detecting schizophrenia in the prodromal phase:
screening of genetic risk relatives |
| title_full | Detecting schizophrenia in the prodromal phase:
screening of genetic risk relatives |
| title_fullStr | Detecting schizophrenia in the prodromal phase:
screening of genetic risk relatives |
| title_full_unstemmed | Detecting schizophrenia in the prodromal phase:
screening of genetic risk relatives |
| title_short | Detecting schizophrenia in the prodromal phase:
screening of genetic risk relatives |
| title_sort | detecting schizophrenia in the prodromal phase screening of genetic risk relatives |
| topic | R Medicine |
| url | http://eprints.usm.my/48690/1/DR.%20MOHD%20RAZALI%20SALLEH-OCR1.pdf |
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