Health and safety: small intestinal bacterial overgrowth is the fundamental mechanism for development of abdominal discomforts from poor water, sanitaion and hygiene (wash) practices after flood disaster
'Background & aims After a major environmental disaster, the affected community is at I increased risk for persistent abdominal pain but exact mechanisms are unclear. We , aimed, firstly, to determine the association between. abdominal pain and poor water, , '.sanitation and hygiene...
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| Format: | Article |
| Language: | English |
| Published: |
Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia
2017
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| Online Access: | http://eprints.usm.my/51981/1/Zahiran_2019_rowing_mohe-Eprints.pdf |
| _version_ | 1825906596435197952 |
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| author | Yeh, Lee Yeong |
| author_facet | Yeh, Lee Yeong |
| author_sort | Yeh, Lee Yeong |
| collection | USM |
| description | 'Background & aims After a major environmental disaster, the affected community is at
I increased risk for persistent abdominal pain but exact mechanisms are unclear. We
, aimed, firstly, to determine the association between. abdominal pain and poor water, ,
'.sanitation and hygiene (waSH) practices, and secondly, to determine if small intestinal '
'bacterial overgrowth (SIBO) and or gut dysbiosis explain the persistent pain.
Methods Flood victims from two severely affected villages in the northeastern region of
Peninsular Malaysia were consented. Their abdominal symptoms after flood that
persisted for six months or more, quality of life, psychological disturbances and WaSH
practices during flood were assessed. For consented participants, glucose breath test
to assess for SIBO and stools for high-throughput sequencing of 165 rRNA gene were ·
performed. A P value < 0.05 was considered significant
Results Of 211 participants (mean age 54.5 ± 1.0 years, females 71 %), 37.9% had
persistent abdominal pain. Poor WaSH practices during flood (adjusted OR 1.11, 95%
'Cl 1.00; 1.24, P = 0.04) and irritable bowel syndrome (adjusted OR 9.53, 95% Cl: 3.51;
25.86, P < 0.001) were significantly associated with abdominal pain. Those with
abdominal pain also experienced worse quality of life and more anxiety, both P < 0.05.
'Of 135 participants who consented for breath-testing, abdominal pain (OR 4.94, 95%
Cl 1.47; 16.55, P = 0.01), poor water practices during flood (OR 1.14, 95% Cl 1.01; 1.30, P = 0.04) and limited physical functioning (OR 0.98, 95% Cl 0.96; 1.00, P = 0.02) .
were significantly associated with SIBO. Based on linear discriminant analysis effect
size (LEfSe) method, there was significant gut dysbiosis observed in those with anxiety
(Bacteroidetes and Proteobacteria, effect size 4.8) and abdominal pain (Fusobacteria,
Staphylococcus, Megamonas and Plesiomonas, effect size 4.0).
Conclusions Gut dysbiosis and SIBO may explain persistent abdominal pain after a
major environmental disaster in the presence of poor WaSH practices. There is also
significant impairment in quality of life and anxiety in flood victims with persistent pain. |
| first_indexed | 2024-03-06T15:51:56Z |
| format | Article |
| id | usm.eprints-51981 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:51:56Z |
| publishDate | 2017 |
| publisher | Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia |
| record_format | dspace |
| spelling | usm.eprints-519812022-03-20T07:20:43Z http://eprints.usm.my/51981/ Health and safety: small intestinal bacterial overgrowth is the fundamental mechanism for development of abdominal discomforts from poor water, sanitaion and hygiene (wash) practices after flood disaster Yeh, Lee Yeong RA Public aspects of medicine 'Background & aims After a major environmental disaster, the affected community is at I increased risk for persistent abdominal pain but exact mechanisms are unclear. We , aimed, firstly, to determine the association between. abdominal pain and poor water, , '.sanitation and hygiene (waSH) practices, and secondly, to determine if small intestinal ' 'bacterial overgrowth (SIBO) and or gut dysbiosis explain the persistent pain. Methods Flood victims from two severely affected villages in the northeastern region of Peninsular Malaysia were consented. Their abdominal symptoms after flood that persisted for six months or more, quality of life, psychological disturbances and WaSH practices during flood were assessed. For consented participants, glucose breath test to assess for SIBO and stools for high-throughput sequencing of 165 rRNA gene were · performed. A P value < 0.05 was considered significant Results Of 211 participants (mean age 54.5 ± 1.0 years, females 71 %), 37.9% had persistent abdominal pain. Poor WaSH practices during flood (adjusted OR 1.11, 95% 'Cl 1.00; 1.24, P = 0.04) and irritable bowel syndrome (adjusted OR 9.53, 95% Cl: 3.51; 25.86, P < 0.001) were significantly associated with abdominal pain. Those with abdominal pain also experienced worse quality of life and more anxiety, both P < 0.05. 'Of 135 participants who consented for breath-testing, abdominal pain (OR 4.94, 95% Cl 1.47; 16.55, P = 0.01), poor water practices during flood (OR 1.14, 95% Cl 1.01; 1.30, P = 0.04) and limited physical functioning (OR 0.98, 95% Cl 0.96; 1.00, P = 0.02) . were significantly associated with SIBO. Based on linear discriminant analysis effect size (LEfSe) method, there was significant gut dysbiosis observed in those with anxiety (Bacteroidetes and Proteobacteria, effect size 4.8) and abdominal pain (Fusobacteria, Staphylococcus, Megamonas and Plesiomonas, effect size 4.0). Conclusions Gut dysbiosis and SIBO may explain persistent abdominal pain after a major environmental disaster in the presence of poor WaSH practices. There is also significant impairment in quality of life and anxiety in flood victims with persistent pain. Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia 2017 Article NonPeerReviewed application/pdf en http://eprints.usm.my/51981/1/Zahiran_2019_rowing_mohe-Eprints.pdf Yeh, Lee Yeong (2017) Health and safety: small intestinal bacterial overgrowth is the fundamental mechanism for development of abdominal discomforts from poor water, sanitaion and hygiene (wash) practices after flood disaster. Health and safety: small intestinal bacterial overgrowth is the fundamental mechanism for development of abdominal discomforts from poor water, sanitaion and hygiene (wash) practices after flood disaster. |
| spellingShingle | RA Public aspects of medicine Yeh, Lee Yeong Health and safety: small intestinal bacterial overgrowth is the fundamental mechanism for development of abdominal discomforts from poor water, sanitaion and hygiene (wash) practices after flood disaster |
| title | Health and safety: small intestinal bacterial
overgrowth is the fundamental mechanism for
development of abdominal discomforts from poor
water, sanitaion and hygiene (wash) practices
after flood disaster |
| title_full | Health and safety: small intestinal bacterial
overgrowth is the fundamental mechanism for
development of abdominal discomforts from poor
water, sanitaion and hygiene (wash) practices
after flood disaster |
| title_fullStr | Health and safety: small intestinal bacterial
overgrowth is the fundamental mechanism for
development of abdominal discomforts from poor
water, sanitaion and hygiene (wash) practices
after flood disaster |
| title_full_unstemmed | Health and safety: small intestinal bacterial
overgrowth is the fundamental mechanism for
development of abdominal discomforts from poor
water, sanitaion and hygiene (wash) practices
after flood disaster |
| title_short | Health and safety: small intestinal bacterial
overgrowth is the fundamental mechanism for
development of abdominal discomforts from poor
water, sanitaion and hygiene (wash) practices
after flood disaster |
| title_sort | health and safety small intestinal bacterial overgrowth is the fundamental mechanism for development of abdominal discomforts from poor water sanitaion and hygiene wash practices after flood disaster |
| topic | RA Public aspects of medicine |
| url | http://eprints.usm.my/51981/1/Zahiran_2019_rowing_mohe-Eprints.pdf |
| work_keys_str_mv | AT yehleeyeong healthandsafetysmallintestinalbacterialovergrowthisthefundamentalmechanismfordevelopmentofabdominaldiscomfortsfrompoorwatersanitaionandhygienewashpracticesafterflooddisaster |