The Clinical Significance Of Npm1, Flt3 And Cebpa Gene Mutations In Adult Patients With Acute Myeloid Leukaemia
Acute myeloid leukaemia (AML) is a biologically complex and clinically heterogeneous haematological cancer, and its incidence increases in the elderly. Age, cytogenetics and genetic mutations remain important prognostic factors for treatment outcome. The main aim of the study was to determine the pr...
| Main Author: | |
|---|---|
| Format: | Thesis |
| Language: | English |
| Published: |
2020
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/52122/1/Pages%20from%20The%20Clinical%20Significance%20Of%20Npm1%2C%20Flt3%20And%20Cebpa%20Gene%20Mutations%20In%20Adult%20Patients%20With%20Acute%20Myeloid%20Leukaemia.pdf |
| _version_ | 1825906622769135616 |
|---|---|
| author | Ul Haq, Izaz |
| author_facet | Ul Haq, Izaz |
| author_sort | Ul Haq, Izaz |
| collection | USM |
| description | Acute myeloid leukaemia (AML) is a biologically complex and clinically heterogeneous haematological cancer, and its incidence increases in the elderly. Age, cytogenetics and genetic mutations remain important prognostic factors for treatment outcome. The main aim of the study was to determine the prevalence and clinical significance of NPM1, FLT3 and CEBPA mutations of AML in the Peninsula Malaysia. Three common and important gene mutations in AML FLT3 (exon 14-15, exon 20), NPM1 (exon 12), and CEBPA (exon 1) were determined by polymerase chain reaction and conformation-sensitive gel electrophoresis (CSGE) in 47 newly diagnosed adult patients with AML. Fisher-Exact Test was used to analyse the significant difference of AML with FLT3-ITD, NPM1, and CEBPA mutants in association with the clinical parameters. |
| first_indexed | 2024-03-06T15:52:19Z |
| format | Thesis |
| id | usm.eprints-52122 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:52:19Z |
| publishDate | 2020 |
| record_format | dspace |
| spelling | usm.eprints-521222022-03-31T07:03:11Z http://eprints.usm.my/52122/ The Clinical Significance Of Npm1, Flt3 And Cebpa Gene Mutations In Adult Patients With Acute Myeloid Leukaemia Ul Haq, Izaz R5-920 Medicine (General) Acute myeloid leukaemia (AML) is a biologically complex and clinically heterogeneous haematological cancer, and its incidence increases in the elderly. Age, cytogenetics and genetic mutations remain important prognostic factors for treatment outcome. The main aim of the study was to determine the prevalence and clinical significance of NPM1, FLT3 and CEBPA mutations of AML in the Peninsula Malaysia. Three common and important gene mutations in AML FLT3 (exon 14-15, exon 20), NPM1 (exon 12), and CEBPA (exon 1) were determined by polymerase chain reaction and conformation-sensitive gel electrophoresis (CSGE) in 47 newly diagnosed adult patients with AML. Fisher-Exact Test was used to analyse the significant difference of AML with FLT3-ITD, NPM1, and CEBPA mutants in association with the clinical parameters. 2020-11 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/52122/1/Pages%20from%20The%20Clinical%20Significance%20Of%20Npm1%2C%20Flt3%20And%20Cebpa%20Gene%20Mutations%20In%20Adult%20Patients%20With%20Acute%20Myeloid%20Leukaemia.pdf Ul Haq, Izaz (2020) The Clinical Significance Of Npm1, Flt3 And Cebpa Gene Mutations In Adult Patients With Acute Myeloid Leukaemia. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | R5-920 Medicine (General) Ul Haq, Izaz The Clinical Significance Of Npm1, Flt3 And Cebpa Gene Mutations In Adult Patients With Acute Myeloid Leukaemia |
| title | The Clinical Significance Of Npm1, Flt3 And Cebpa Gene Mutations In Adult Patients With Acute Myeloid Leukaemia |
| title_full | The Clinical Significance Of Npm1, Flt3 And Cebpa Gene Mutations In Adult Patients With Acute Myeloid Leukaemia |
| title_fullStr | The Clinical Significance Of Npm1, Flt3 And Cebpa Gene Mutations In Adult Patients With Acute Myeloid Leukaemia |
| title_full_unstemmed | The Clinical Significance Of Npm1, Flt3 And Cebpa Gene Mutations In Adult Patients With Acute Myeloid Leukaemia |
| title_short | The Clinical Significance Of Npm1, Flt3 And Cebpa Gene Mutations In Adult Patients With Acute Myeloid Leukaemia |
| title_sort | clinical significance of npm1 flt3 and cebpa gene mutations in adult patients with acute myeloid leukaemia |
| topic | R5-920 Medicine (General) |
| url | http://eprints.usm.my/52122/1/Pages%20from%20The%20Clinical%20Significance%20Of%20Npm1%2C%20Flt3%20And%20Cebpa%20Gene%20Mutations%20In%20Adult%20Patients%20With%20Acute%20Myeloid%20Leukaemia.pdf |
| work_keys_str_mv | AT ulhaqizaz theclinicalsignificanceofnpm1flt3andcebpagenemutationsinadultpatientswithacutemyeloidleukaemia AT ulhaqizaz clinicalsignificanceofnpm1flt3andcebpagenemutationsinadultpatientswithacutemyeloidleukaemia |