Synthesis, X-Ray Structure Characterization And Antioxidant Activities Of Some Chalcone Derivatives Containing 2-Chlorothiophene Moiety

A total of twelve heterocyclic chalcone compounds (1a-1l) containing 2-chlorothiophene moieties were synthesized using Claisen Schmidt Condensation process and were crystallized by slow evaporation methods. The postulate structure of these heterocyclic chalcone compounds were elucidated by FT-IR and...

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Main Author: Ng, Weng Zhun
Format: Thesis
Language:English
Published: 2021
Subjects:
Online Access:http://eprints.usm.my/52192/1/NG%20WENG%20ZHUN%20-%20TESIS.pdf
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author Ng, Weng Zhun
author_facet Ng, Weng Zhun
author_sort Ng, Weng Zhun
collection USM
description A total of twelve heterocyclic chalcone compounds (1a-1l) containing 2-chlorothiophene moieties were synthesized using Claisen Schmidt Condensation process and were crystallized by slow evaporation methods. The postulate structure of these heterocyclic chalcone compounds were elucidated by FT-IR and NMR spectral analyses, followed by single crystal X-ray diffraction technique. Besides, the antioxidant potential of all compounds was evaluated using four different types of antioxidant assay which include 2, 2-diphenyl-1-picrylhydrazyl (DPPH), ferrous ion chelating (FIC), nitric oxide (NO) and Hydrogen Peroxide (H2O2) radical scavenging assay. Nine compounds are crystallized in monoclinic space group with four compounds in P21/c, three compounds in P21/n and two compounds in Cc and Pc. Another, two compounds are crystallized in triclinic space group
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spelling usm.eprints-521922022-04-05T08:08:35Z http://eprints.usm.my/52192/ Synthesis, X-Ray Structure Characterization And Antioxidant Activities Of Some Chalcone Derivatives Containing 2-Chlorothiophene Moiety Ng, Weng Zhun QC1 Physics (General) A total of twelve heterocyclic chalcone compounds (1a-1l) containing 2-chlorothiophene moieties were synthesized using Claisen Schmidt Condensation process and were crystallized by slow evaporation methods. The postulate structure of these heterocyclic chalcone compounds were elucidated by FT-IR and NMR spectral analyses, followed by single crystal X-ray diffraction technique. Besides, the antioxidant potential of all compounds was evaluated using four different types of antioxidant assay which include 2, 2-diphenyl-1-picrylhydrazyl (DPPH), ferrous ion chelating (FIC), nitric oxide (NO) and Hydrogen Peroxide (H2O2) radical scavenging assay. Nine compounds are crystallized in monoclinic space group with four compounds in P21/c, three compounds in P21/n and two compounds in Cc and Pc. Another, two compounds are crystallized in triclinic space group 2021-03 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/52192/1/NG%20WENG%20ZHUN%20-%20TESIS.pdf Ng, Weng Zhun (2021) Synthesis, X-Ray Structure Characterization And Antioxidant Activities Of Some Chalcone Derivatives Containing 2-Chlorothiophene Moiety. Masters thesis, Perpustakaan Hamzah Sendut.
spellingShingle QC1 Physics (General)
Ng, Weng Zhun
Synthesis, X-Ray Structure Characterization And Antioxidant Activities Of Some Chalcone Derivatives Containing 2-Chlorothiophene Moiety
title Synthesis, X-Ray Structure Characterization And Antioxidant Activities Of Some Chalcone Derivatives Containing 2-Chlorothiophene Moiety
title_full Synthesis, X-Ray Structure Characterization And Antioxidant Activities Of Some Chalcone Derivatives Containing 2-Chlorothiophene Moiety
title_fullStr Synthesis, X-Ray Structure Characterization And Antioxidant Activities Of Some Chalcone Derivatives Containing 2-Chlorothiophene Moiety
title_full_unstemmed Synthesis, X-Ray Structure Characterization And Antioxidant Activities Of Some Chalcone Derivatives Containing 2-Chlorothiophene Moiety
title_short Synthesis, X-Ray Structure Characterization And Antioxidant Activities Of Some Chalcone Derivatives Containing 2-Chlorothiophene Moiety
title_sort synthesis x ray structure characterization and antioxidant activities of some chalcone derivatives containing 2 chlorothiophene moiety
topic QC1 Physics (General)
url http://eprints.usm.my/52192/1/NG%20WENG%20ZHUN%20-%20TESIS.pdf
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