Synthesis, X-Ray Structure Characterization And Antioxidant Activities Of Some Chalcone Derivatives Containing 2-Chlorothiophene Moiety
A total of twelve heterocyclic chalcone compounds (1a-1l) containing 2-chlorothiophene moieties were synthesized using Claisen Schmidt Condensation process and were crystallized by slow evaporation methods. The postulate structure of these heterocyclic chalcone compounds were elucidated by FT-IR and...
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Format: | Thesis |
Language: | English |
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2021
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Online Access: | http://eprints.usm.my/52192/1/NG%20WENG%20ZHUN%20-%20TESIS.pdf |
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author | Ng, Weng Zhun |
author_facet | Ng, Weng Zhun |
author_sort | Ng, Weng Zhun |
collection | USM |
description | A total of twelve heterocyclic chalcone compounds (1a-1l) containing 2-chlorothiophene moieties were synthesized using Claisen Schmidt Condensation process and were crystallized by slow evaporation methods. The postulate structure of these heterocyclic chalcone compounds were elucidated by FT-IR and NMR spectral analyses, followed by single crystal X-ray diffraction technique. Besides, the antioxidant potential of all compounds was evaluated using four different types of antioxidant assay which include 2, 2-diphenyl-1-picrylhydrazyl (DPPH), ferrous ion chelating (FIC), nitric oxide (NO) and Hydrogen Peroxide (H2O2) radical scavenging assay. Nine compounds are crystallized in monoclinic space group with four compounds in P21/c, three compounds in P21/n and two compounds in Cc and Pc. Another, two compounds are crystallized in triclinic space group |
first_indexed | 2024-03-06T15:52:31Z |
format | Thesis |
id | usm.eprints-52192 |
institution | Universiti Sains Malaysia |
language | English |
last_indexed | 2024-03-06T15:52:31Z |
publishDate | 2021 |
record_format | dspace |
spelling | usm.eprints-521922022-04-05T08:08:35Z http://eprints.usm.my/52192/ Synthesis, X-Ray Structure Characterization And Antioxidant Activities Of Some Chalcone Derivatives Containing 2-Chlorothiophene Moiety Ng, Weng Zhun QC1 Physics (General) A total of twelve heterocyclic chalcone compounds (1a-1l) containing 2-chlorothiophene moieties were synthesized using Claisen Schmidt Condensation process and were crystallized by slow evaporation methods. The postulate structure of these heterocyclic chalcone compounds were elucidated by FT-IR and NMR spectral analyses, followed by single crystal X-ray diffraction technique. Besides, the antioxidant potential of all compounds was evaluated using four different types of antioxidant assay which include 2, 2-diphenyl-1-picrylhydrazyl (DPPH), ferrous ion chelating (FIC), nitric oxide (NO) and Hydrogen Peroxide (H2O2) radical scavenging assay. Nine compounds are crystallized in monoclinic space group with four compounds in P21/c, three compounds in P21/n and two compounds in Cc and Pc. Another, two compounds are crystallized in triclinic space group 2021-03 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/52192/1/NG%20WENG%20ZHUN%20-%20TESIS.pdf Ng, Weng Zhun (2021) Synthesis, X-Ray Structure Characterization And Antioxidant Activities Of Some Chalcone Derivatives Containing 2-Chlorothiophene Moiety. Masters thesis, Perpustakaan Hamzah Sendut. |
spellingShingle | QC1 Physics (General) Ng, Weng Zhun Synthesis, X-Ray Structure Characterization And Antioxidant Activities Of Some Chalcone Derivatives Containing 2-Chlorothiophene Moiety |
title | Synthesis, X-Ray Structure Characterization And Antioxidant Activities Of Some Chalcone Derivatives Containing 2-Chlorothiophene Moiety |
title_full | Synthesis, X-Ray Structure Characterization And Antioxidant Activities Of Some Chalcone Derivatives Containing 2-Chlorothiophene Moiety |
title_fullStr | Synthesis, X-Ray Structure Characterization And Antioxidant Activities Of Some Chalcone Derivatives Containing 2-Chlorothiophene Moiety |
title_full_unstemmed | Synthesis, X-Ray Structure Characterization And Antioxidant Activities Of Some Chalcone Derivatives Containing 2-Chlorothiophene Moiety |
title_short | Synthesis, X-Ray Structure Characterization And Antioxidant Activities Of Some Chalcone Derivatives Containing 2-Chlorothiophene Moiety |
title_sort | synthesis x ray structure characterization and antioxidant activities of some chalcone derivatives containing 2 chlorothiophene moiety |
topic | QC1 Physics (General) |
url | http://eprints.usm.my/52192/1/NG%20WENG%20ZHUN%20-%20TESIS.pdf |
work_keys_str_mv | AT ngwengzhun synthesisxraystructurecharacterizationandantioxidantactivitiesofsomechalconederivativescontaining2chlorothiophenemoiety |