Obesity intervention outcome: i)the effect of pharmacological intervention in failed lifestyle intervention ii)weight loss maintenance with cessation of pharmacological intervention
This study aimed to determine the effect of anti-obesity drug treatment in overweight and obese subjects who had failed to achieve satisfactory weight loss after a 9 months' weight loss intervention programme involving education on lifestyle modification. 25 subjects had originally undergone...
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| Format: | Monograph |
| Language: | English |
| Published: |
Pusat Pengajian Sains Perubatan
2013
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| Online Access: | http://eprints.usm.my/54668/1/DR.%20AIDA%20HANUM%20GHULAM%20RASOOL%20-%20e.pdf |
| _version_ | 1797013268587347968 |
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| author | Aida Hanum, Ghulam Rasool |
| author_facet | Aida Hanum, Ghulam Rasool |
| author_sort | Aida Hanum, Ghulam Rasool |
| collection | USM |
| description | This study aimed to determine the effect of anti-obesity drug treatment in
overweight and obese subjects who had failed to achieve satisfactory weight loss after a 9
months' weight loss intervention programme involving education on lifestyle modification. 25 subjects had originally undergone a 9 months' intervention programme
aimed to reduce weight involving education on lifestyle modification. 11 (8 females and 3 males)
subjects who had failed to reduce their weight satisfactorily (defined as still having body mass
index (BMI) 2: 27 kg/m2 after intervention) were offered anti-obesity drugs for a period of 4
months. Anthropometric measurements, body composition (body and visceral fat percentages),
metabolic and cardiovascular (CVS) profiles were measured at 9 months after completing
lifestyle modification, and repeated at the end of 4 months with anti-obesity drugs. Anti-obesity
drugs used in this study were orlistat 120 mg three times daily or sibutramine 10- 15 mg daily. subjects were on orlistat while 4 were on sibutrarnine. These 11 subjects did
not significantly reduce weight when they were on 9 months education on lifestyle modification,
mean weight before and after intervention was 75.7 (18.8) vs 76.5 (21.0) kg; p=0.452. Weight
reduced significantly after 4 months drug treatment by 2.06 kg (p=0.041). Visceral fat
significantly reduced from 13.7 (6.5)% to 12.9 (6.9)% (p=0.036) after drug treatment. A
borderline reduction in waist circumference was seen (87.2 (10.2) em vs 85.9 (11.0) em, (p =
0.073). No difference was seen in lipid profile, fasting blood sugar, insulin level and resistance,
blood pressure and arterial stiffuess with 4 months anti-obesity agents. Or!istat and Sibutramine reduced weight significantly in subjects who had
failed to reduce weight with education on lifestyle medication. The weight reduction was
however modest at 2.7% and was not associated with improvements in other CVS and metabolic
risk markers. |
| first_indexed | 2024-03-06T15:59:45Z |
| format | Monograph |
| id | usm.eprints-54668 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T15:59:45Z |
| publishDate | 2013 |
| publisher | Pusat Pengajian Sains Perubatan |
| record_format | dspace |
| spelling | usm.eprints-546682022-09-14T06:28:36Z http://eprints.usm.my/54668/ Obesity intervention outcome: i)the effect of pharmacological intervention in failed lifestyle intervention ii)weight loss maintenance with cessation of pharmacological intervention Aida Hanum, Ghulam Rasool R5-920 Medicine (General) This study aimed to determine the effect of anti-obesity drug treatment in overweight and obese subjects who had failed to achieve satisfactory weight loss after a 9 months' weight loss intervention programme involving education on lifestyle modification. 25 subjects had originally undergone a 9 months' intervention programme aimed to reduce weight involving education on lifestyle modification. 11 (8 females and 3 males) subjects who had failed to reduce their weight satisfactorily (defined as still having body mass index (BMI) 2: 27 kg/m2 after intervention) were offered anti-obesity drugs for a period of 4 months. Anthropometric measurements, body composition (body and visceral fat percentages), metabolic and cardiovascular (CVS) profiles were measured at 9 months after completing lifestyle modification, and repeated at the end of 4 months with anti-obesity drugs. Anti-obesity drugs used in this study were orlistat 120 mg three times daily or sibutramine 10- 15 mg daily. subjects were on orlistat while 4 were on sibutrarnine. These 11 subjects did not significantly reduce weight when they were on 9 months education on lifestyle modification, mean weight before and after intervention was 75.7 (18.8) vs 76.5 (21.0) kg; p=0.452. Weight reduced significantly after 4 months drug treatment by 2.06 kg (p=0.041). Visceral fat significantly reduced from 13.7 (6.5)% to 12.9 (6.9)% (p=0.036) after drug treatment. A borderline reduction in waist circumference was seen (87.2 (10.2) em vs 85.9 (11.0) em, (p = 0.073). No difference was seen in lipid profile, fasting blood sugar, insulin level and resistance, blood pressure and arterial stiffuess with 4 months anti-obesity agents. Or!istat and Sibutramine reduced weight significantly in subjects who had failed to reduce weight with education on lifestyle medication. The weight reduction was however modest at 2.7% and was not associated with improvements in other CVS and metabolic risk markers. Pusat Pengajian Sains Perubatan 2013 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/54668/1/DR.%20AIDA%20HANUM%20GHULAM%20RASOOL%20-%20e.pdf Aida Hanum, Ghulam Rasool (2013) Obesity intervention outcome: i)the effect of pharmacological intervention in failed lifestyle intervention ii)weight loss maintenance with cessation of pharmacological intervention. Other. Pusat Pengajian Sains Perubatan. (Submitted) |
| spellingShingle | R5-920 Medicine (General) Aida Hanum, Ghulam Rasool Obesity intervention outcome: i)the effect of pharmacological intervention in failed lifestyle intervention ii)weight loss maintenance with cessation of pharmacological intervention |
| title | Obesity intervention outcome: i)the effect of
pharmacological intervention in failed
lifestyle intervention ii)weight loss
maintenance with cessation of
pharmacological intervention |
| title_full | Obesity intervention outcome: i)the effect of
pharmacological intervention in failed
lifestyle intervention ii)weight loss
maintenance with cessation of
pharmacological intervention |
| title_fullStr | Obesity intervention outcome: i)the effect of
pharmacological intervention in failed
lifestyle intervention ii)weight loss
maintenance with cessation of
pharmacological intervention |
| title_full_unstemmed | Obesity intervention outcome: i)the effect of
pharmacological intervention in failed
lifestyle intervention ii)weight loss
maintenance with cessation of
pharmacological intervention |
| title_short | Obesity intervention outcome: i)the effect of
pharmacological intervention in failed
lifestyle intervention ii)weight loss
maintenance with cessation of
pharmacological intervention |
| title_sort | obesity intervention outcome i the effect of pharmacological intervention in failed lifestyle intervention ii weight loss maintenance with cessation of pharmacological intervention |
| topic | R5-920 Medicine (General) |
| url | http://eprints.usm.my/54668/1/DR.%20AIDA%20HANUM%20GHULAM%20RASOOL%20-%20e.pdf |
| work_keys_str_mv | AT aidahanumghulamrasool obesityinterventionoutcomeitheeffectofpharmacologicalinterventioninfailedlifestyleinterventioniiweightlossmaintenancewithcessationofpharmacologicalintervention |