Biocompatibility Of Electrospun Bombyx Mori Silk Fibroin With Poly(3-Hydroxybutyrate-Co-3-Hydroxyhexanoate) As A Biomaterial For Tissue-Engineered Scaffolds
Polyhydroxyalkanoates (PHAs) are polyesters produced by microorganisms under unbalanced growth conditions. They are well documented as a biodegradable and biocompatible polymer, making them attractive as biomaterials for applications in tissue engineering. Poly(3-hydroxybutyrate-co-3-hydroxyhexanoat...
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| Format: | Thesis |
| Language: | English |
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2019
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| Online Access: | http://eprints.usm.my/55696/1/24%20Pages%20from%20Ang%20Shaik%20Ling.pdf |
| _version_ | 1825907345949982720 |
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| author | Ang, Shaik Ling |
| author_facet | Ang, Shaik Ling |
| author_sort | Ang, Shaik Ling |
| collection | USM |
| description | Polyhydroxyalkanoates (PHAs) are polyesters produced by microorganisms under unbalanced growth conditions. They are well documented as a biodegradable and biocompatible polymer, making them attractive as biomaterials for applications in tissue engineering. Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) P(3HB-co-3HHx) is one of the members of the PHA family that has shown superior mechanical properties and processability compared to poly(3-hydroxybutyrate) [P(3HB)] and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [(P(3HB-co-3HV)]. However, the biocompatibility of P(3HB-co-3HHx) is still inadequate because of its hydrophobic properties that has hampered its direct use as scaffold material. In this study, silk fibroin (SF) derived from Bombyx mori cocoons, which is a widely used and studied protein polymer for biomaterial applications have been used to improve the cell affinity and biocompatibility of P(3HB-co-3HHx). |
| first_indexed | 2024-03-06T16:02:52Z |
| format | Thesis |
| id | usm.eprints-55696 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T16:02:52Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | usm.eprints-556962022-11-17T07:03:33Z http://eprints.usm.my/55696/ Biocompatibility Of Electrospun Bombyx Mori Silk Fibroin With Poly(3-Hydroxybutyrate-Co-3-Hydroxyhexanoate) As A Biomaterial For Tissue-Engineered Scaffolds Ang, Shaik Ling QH1-278.5 Natural history (General) Polyhydroxyalkanoates (PHAs) are polyesters produced by microorganisms under unbalanced growth conditions. They are well documented as a biodegradable and biocompatible polymer, making them attractive as biomaterials for applications in tissue engineering. Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) P(3HB-co-3HHx) is one of the members of the PHA family that has shown superior mechanical properties and processability compared to poly(3-hydroxybutyrate) [P(3HB)] and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [(P(3HB-co-3HV)]. However, the biocompatibility of P(3HB-co-3HHx) is still inadequate because of its hydrophobic properties that has hampered its direct use as scaffold material. In this study, silk fibroin (SF) derived from Bombyx mori cocoons, which is a widely used and studied protein polymer for biomaterial applications have been used to improve the cell affinity and biocompatibility of P(3HB-co-3HHx). 2019-12 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/55696/1/24%20Pages%20from%20Ang%20Shaik%20Ling.pdf Ang, Shaik Ling (2019) Biocompatibility Of Electrospun Bombyx Mori Silk Fibroin With Poly(3-Hydroxybutyrate-Co-3-Hydroxyhexanoate) As A Biomaterial For Tissue-Engineered Scaffolds. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | QH1-278.5 Natural history (General) Ang, Shaik Ling Biocompatibility Of Electrospun Bombyx Mori Silk Fibroin With Poly(3-Hydroxybutyrate-Co-3-Hydroxyhexanoate) As A Biomaterial For Tissue-Engineered Scaffolds |
| title | Biocompatibility Of Electrospun Bombyx Mori Silk Fibroin With Poly(3-Hydroxybutyrate-Co-3-Hydroxyhexanoate) As A Biomaterial For Tissue-Engineered Scaffolds |
| title_full | Biocompatibility Of Electrospun Bombyx Mori Silk Fibroin With Poly(3-Hydroxybutyrate-Co-3-Hydroxyhexanoate) As A Biomaterial For Tissue-Engineered Scaffolds |
| title_fullStr | Biocompatibility Of Electrospun Bombyx Mori Silk Fibroin With Poly(3-Hydroxybutyrate-Co-3-Hydroxyhexanoate) As A Biomaterial For Tissue-Engineered Scaffolds |
| title_full_unstemmed | Biocompatibility Of Electrospun Bombyx Mori Silk Fibroin With Poly(3-Hydroxybutyrate-Co-3-Hydroxyhexanoate) As A Biomaterial For Tissue-Engineered Scaffolds |
| title_short | Biocompatibility Of Electrospun Bombyx Mori Silk Fibroin With Poly(3-Hydroxybutyrate-Co-3-Hydroxyhexanoate) As A Biomaterial For Tissue-Engineered Scaffolds |
| title_sort | biocompatibility of electrospun bombyx mori silk fibroin with poly 3 hydroxybutyrate co 3 hydroxyhexanoate as a biomaterial for tissue engineered scaffolds |
| topic | QH1-278.5 Natural history (General) |
| url | http://eprints.usm.my/55696/1/24%20Pages%20from%20Ang%20Shaik%20Ling.pdf |
| work_keys_str_mv | AT angshaikling biocompatibilityofelectrospunbombyxmorisilkfibroinwithpoly3hydroxybutyrateco3hydroxyhexanoateasabiomaterialfortissueengineeredscaffolds |