| Summary: | Desflurane has a rapid onset and offset of anaesthesia, thus minimising
complications associated with prolonged recovery compared to sevoflurane. Nevertheless, due
to its pungency, it is avoided as induction agent in paediatric as it may cause airway irritability.
This study aimed to evaluate the haemodynamic, emergence time, emergence agitation and
respiratory adverse event of desflurane in comparison to sevoflurane in maintaining general
anaesthesia with spontaneous breathing in paediatric population using AmbuÒAuraGainÔ, as
previous studies were done in paralysed and controlled ventilated patients. This study was prospective, single blinded, single centre and randomised
controlled trial. A total of 80 American Society of Anaesthesiologists (ASA) physical status I
children patients underwent short (1 to 2 hours) elective surgeries were randomised into two
groups; sevoflurane (Group S, n = 40): and desflurane (Group D, n = 40) for maintenance of
spontaneous breathing general anaesthesia. Both groups were observed for emergence time,
frequency and severity of emergence agitation, the respiratory adverse events and
intraoperative and post-operative haemodynamic of every 10 minutes. All data were analysed
using independent t-test, Pearson chi-squared and repeated measures ANOVA respectively. Emergence time was significantly shorter [6.92(2.47) vs 9.95(55.52), P = 0.003]
with reduced frequency and severity of emergence agitation (P = 0.014) in desflurane group
compare to sevoflurane. However, there was no significance difference in term of
intraoperative haemodynamic for SBP, DBP, MAP and HR and perioperative respiratory
adverse events in both groups (P > 0.05 respectively). Maintenance of general anaesthesia with spontaneous breathing in
paediatrics using desflurane had faster emergence time with reduced frequency and severity of
emergence agitation as compared to sevoflurane.
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