Rational Design And Synthesis Of Peptide Inhibitors Of Ns2b/Ns3 Protease As Therapeutic Agents For Dengue Virus Type 2
The main objectives of this study are to design potent and selective peptide inhibitors by studying the interactions between the designed peptides and the NS2B/NS3 dengue protease using two independent docking programs (MOE and AutoDock4.2), thus, to evaluate the quantitative and qualitative docking...
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| Format: | Thesis |
| Language: | English |
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2021
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| Online Access: | http://eprints.usm.my/59307/1/NADEEM%20ABDALSATAR%20ABDALRAZAQ%20ABDALRAZAQ%20-%20TESIS%20cut.pdf |
| _version_ | 1825908063266144256 |
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| author | Abdalrazaq, Nadeem Abdalsatar |
| author_facet | Abdalrazaq, Nadeem Abdalsatar |
| author_sort | Abdalrazaq, Nadeem Abdalsatar |
| collection | USM |
| description | The main objectives of this study are to design potent and selective peptide inhibitors by studying the interactions between the designed peptides and the NS2B/NS3 dengue protease using two independent docking programs (MOE and AutoDock4.2), thus, to evaluate the quantitative and qualitative docking results from both programs. The other objectives are to synthesize and characterize the potential peptides by using Fmoc Solid Phase Peptide Synthesis (SPPS) technique, to perform NS2B/NS3 dengue protease expression and purification, and finally to investigate the biological evaluation of the selected peptides using in vitro NS2B/NS3 dengue protease inhibition assay. |
| first_indexed | 2024-03-06T16:13:24Z |
| format | Thesis |
| id | usm.eprints-59307 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T16:13:24Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | usm.eprints-593072023-09-01T02:10:49Z http://eprints.usm.my/59307/ Rational Design And Synthesis Of Peptide Inhibitors Of Ns2b/Ns3 Protease As Therapeutic Agents For Dengue Virus Type 2 Abdalrazaq, Nadeem Abdalsatar RS1-441 Pharmacy and materia medica The main objectives of this study are to design potent and selective peptide inhibitors by studying the interactions between the designed peptides and the NS2B/NS3 dengue protease using two independent docking programs (MOE and AutoDock4.2), thus, to evaluate the quantitative and qualitative docking results from both programs. The other objectives are to synthesize and characterize the potential peptides by using Fmoc Solid Phase Peptide Synthesis (SPPS) technique, to perform NS2B/NS3 dengue protease expression and purification, and finally to investigate the biological evaluation of the selected peptides using in vitro NS2B/NS3 dengue protease inhibition assay. 2021-10 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/59307/1/NADEEM%20ABDALSATAR%20ABDALRAZAQ%20ABDALRAZAQ%20-%20TESIS%20cut.pdf Abdalrazaq, Nadeem Abdalsatar (2021) Rational Design And Synthesis Of Peptide Inhibitors Of Ns2b/Ns3 Protease As Therapeutic Agents For Dengue Virus Type 2. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Abdalrazaq, Nadeem Abdalsatar Rational Design And Synthesis Of Peptide Inhibitors Of Ns2b/Ns3 Protease As Therapeutic Agents For Dengue Virus Type 2 |
| title | Rational Design And Synthesis Of Peptide Inhibitors Of Ns2b/Ns3 Protease As Therapeutic Agents For Dengue Virus Type 2 |
| title_full | Rational Design And Synthesis Of Peptide Inhibitors Of Ns2b/Ns3 Protease As Therapeutic Agents For Dengue Virus Type 2 |
| title_fullStr | Rational Design And Synthesis Of Peptide Inhibitors Of Ns2b/Ns3 Protease As Therapeutic Agents For Dengue Virus Type 2 |
| title_full_unstemmed | Rational Design And Synthesis Of Peptide Inhibitors Of Ns2b/Ns3 Protease As Therapeutic Agents For Dengue Virus Type 2 |
| title_short | Rational Design And Synthesis Of Peptide Inhibitors Of Ns2b/Ns3 Protease As Therapeutic Agents For Dengue Virus Type 2 |
| title_sort | rational design and synthesis of peptide inhibitors of ns2b ns3 protease as therapeutic agents for dengue virus type 2 |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/59307/1/NADEEM%20ABDALSATAR%20ABDALRAZAQ%20ABDALRAZAQ%20-%20TESIS%20cut.pdf |
| work_keys_str_mv | AT abdalrazaqnadeemabdalsatar rationaldesignandsynthesisofpeptideinhibitorsofns2bns3proteaseastherapeuticagentsfordenguevirustype2 |