Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival
Malaysia has one of the highest national incidences of Nasopharyngeal carcinoma (NPC) in South-East Asia. Treating patients with metastatic NPC is often a challenge as patients develop resistance to systemic anti-cancer therapies such as chemotherapy and retreating local recurrence with radiother...
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| Format: | Thesis |
| Language: | English |
| Published: |
2022
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| Online Access: | http://eprints.usm.my/60127/1/24%20Pages%20from%20SITI%20FAIRUS%20BINTI%20ABDUL%20RAHMAN.pdf |
| _version_ | 1825908220131016704 |
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| author | Abdul Rahman, Siti Fairus |
| author_facet | Abdul Rahman, Siti Fairus |
| author_sort | Abdul Rahman, Siti Fairus |
| collection | USM |
| description | Malaysia has one of the highest national incidences of Nasopharyngeal
carcinoma (NPC) in South-East Asia. Treating patients with metastatic NPC is often a
challenge as patients develop resistance to systemic anti-cancer therapies such as
chemotherapy and retreating local recurrence with radiotherapy have many limitations.
Hence, improved treatment strategies are needed for better patient outcome. Upregulation
of the anti-apoptotic protein BCL-2 is one of the strategies that cancer cells
adopt to evade cell death. Hence, these proteins have become attractive therapeutic
targets. Given that different cell population rely on different anti-apoptotic proteins for
survival, it is crucial to determine which proteins are important for NPC cell survival.
Previous study reported that co-inhibition of BCL-2 and BCL-XL did not induce cell
killing in NPC cells, which indicate that either MCL-1 or BFL-1 may play an important
role in the survival the NPC cells. Given that the roles of MCL-1 and BFL-1 for NPC
cell survival are under-explored, this study will primarily focus on delineating the
functional roles of these two molecules for cell survival using gene editing and
pharmacological approaches. |
| first_indexed | 2024-04-09T03:53:04Z |
| format | Thesis |
| id | usm.eprints-60127 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-04-09T03:53:04Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | usm.eprints-601272024-03-12T01:53:26Z http://eprints.usm.my/60127/ Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival Abdul Rahman, Siti Fairus QH1-278.5 Natural history (General) Malaysia has one of the highest national incidences of Nasopharyngeal carcinoma (NPC) in South-East Asia. Treating patients with metastatic NPC is often a challenge as patients develop resistance to systemic anti-cancer therapies such as chemotherapy and retreating local recurrence with radiotherapy have many limitations. Hence, improved treatment strategies are needed for better patient outcome. Upregulation of the anti-apoptotic protein BCL-2 is one of the strategies that cancer cells adopt to evade cell death. Hence, these proteins have become attractive therapeutic targets. Given that different cell population rely on different anti-apoptotic proteins for survival, it is crucial to determine which proteins are important for NPC cell survival. Previous study reported that co-inhibition of BCL-2 and BCL-XL did not induce cell killing in NPC cells, which indicate that either MCL-1 or BFL-1 may play an important role in the survival the NPC cells. Given that the roles of MCL-1 and BFL-1 for NPC cell survival are under-explored, this study will primarily focus on delineating the functional roles of these two molecules for cell survival using gene editing and pharmacological approaches. 2022-11 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/60127/1/24%20Pages%20from%20SITI%20FAIRUS%20BINTI%20ABDUL%20RAHMAN.pdf Abdul Rahman, Siti Fairus (2022) Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival. PhD thesis, Perpustakaan Hamzah Sendut. |
| spellingShingle | QH1-278.5 Natural history (General) Abdul Rahman, Siti Fairus Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival |
| title | Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival |
| title_full | Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival |
| title_fullStr | Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival |
| title_full_unstemmed | Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival |
| title_short | Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival |
| title_sort | anti apoptotic proteins mcl 1 and bcl xl are crucial for nasopharyngeal carcinoma cell survival |
| topic | QH1-278.5 Natural history (General) |
| url | http://eprints.usm.my/60127/1/24%20Pages%20from%20SITI%20FAIRUS%20BINTI%20ABDUL%20RAHMAN.pdf |
| work_keys_str_mv | AT abdulrahmansitifairus antiapoptoticproteinsmcl1andbclxlarecrucialfornasopharyngealcarcinomacellsurvival |