A Study On Cyp2c19 Genetic Variations Of Clopidogrel And Ticagrelor Treatment Among Coronary Artery Disease (CAD) Patients Undergoing Percutaneous Coronary Intervention (PCI)
The P2Y12 receptor inhibitors, especially clopidogrel, are common antiplatelet drugs used for the prevention of recurrent adverse cardiovascular events among patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). Several factors may affect the effectiveness...
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| Format: | Thesis |
| Language: | English |
| Published: |
2023
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| Online Access: | http://eprints.usm.my/60515/1/Pages%20from%20MOHAMMED%20AHMED%20IMRAN%20AK-KAIF%20-%20TESIS.pdf |
| _version_ | 1825908297003171840 |
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| author | Ak-Kaif, Mohammed Ahmed Imran |
| author_facet | Ak-Kaif, Mohammed Ahmed Imran |
| author_sort | Ak-Kaif, Mohammed Ahmed Imran |
| collection | USM |
| description | The P2Y12 receptor inhibitors, especially clopidogrel, are common antiplatelet drugs used for the prevention of recurrent adverse cardiovascular events among
patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). Several factors may affect the effectiveness of antiplatelet therapy,
including genetic variations in CYP450 enzymes. Loss of function (LOF) carriers of the CYP2C19 gene are associated with the decreased metabolism of clopidogrel into
active metabolites via CYP2C19 enzyme, leading to decreased platelet inhibition. This causes an increased risk of recurrent cardiovascular events. Drug regulatory authorities
suggested using alternative P2Y12 inhibitor, which is ticagrelor. Therefore, this study aims to investigate the adverse effects, and CYP2C19 genetic variations of clopidogrel and ticagrelor treatment among CAD patients undergoing PCI. |
| first_indexed | 2024-09-25T03:56:28Z |
| format | Thesis |
| id | usm.eprints-60515 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-09-25T03:56:28Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | usm.eprints-605152024-05-03T00:33:38Z http://eprints.usm.my/60515/ A Study On Cyp2c19 Genetic Variations Of Clopidogrel And Ticagrelor Treatment Among Coronary Artery Disease (CAD) Patients Undergoing Percutaneous Coronary Intervention (PCI) Ak-Kaif, Mohammed Ahmed Imran RS1-441 Pharmacy and materia medica The P2Y12 receptor inhibitors, especially clopidogrel, are common antiplatelet drugs used for the prevention of recurrent adverse cardiovascular events among patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). Several factors may affect the effectiveness of antiplatelet therapy, including genetic variations in CYP450 enzymes. Loss of function (LOF) carriers of the CYP2C19 gene are associated with the decreased metabolism of clopidogrel into active metabolites via CYP2C19 enzyme, leading to decreased platelet inhibition. This causes an increased risk of recurrent cardiovascular events. Drug regulatory authorities suggested using alternative P2Y12 inhibitor, which is ticagrelor. Therefore, this study aims to investigate the adverse effects, and CYP2C19 genetic variations of clopidogrel and ticagrelor treatment among CAD patients undergoing PCI. 2023-06 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/60515/1/Pages%20from%20MOHAMMED%20AHMED%20IMRAN%20AK-KAIF%20-%20TESIS.pdf Ak-Kaif, Mohammed Ahmed Imran (2023) A Study On Cyp2c19 Genetic Variations Of Clopidogrel And Ticagrelor Treatment Among Coronary Artery Disease (CAD) Patients Undergoing Percutaneous Coronary Intervention (PCI). PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | RS1-441 Pharmacy and materia medica Ak-Kaif, Mohammed Ahmed Imran A Study On Cyp2c19 Genetic Variations Of Clopidogrel And Ticagrelor Treatment Among Coronary Artery Disease (CAD) Patients Undergoing Percutaneous Coronary Intervention (PCI) |
| title | A Study On Cyp2c19 Genetic Variations Of Clopidogrel And Ticagrelor Treatment Among Coronary Artery Disease (CAD) Patients Undergoing Percutaneous Coronary Intervention (PCI) |
| title_full | A Study On Cyp2c19 Genetic Variations Of Clopidogrel And Ticagrelor Treatment Among Coronary Artery Disease (CAD) Patients Undergoing Percutaneous Coronary Intervention (PCI) |
| title_fullStr | A Study On Cyp2c19 Genetic Variations Of Clopidogrel And Ticagrelor Treatment Among Coronary Artery Disease (CAD) Patients Undergoing Percutaneous Coronary Intervention (PCI) |
| title_full_unstemmed | A Study On Cyp2c19 Genetic Variations Of Clopidogrel And Ticagrelor Treatment Among Coronary Artery Disease (CAD) Patients Undergoing Percutaneous Coronary Intervention (PCI) |
| title_short | A Study On Cyp2c19 Genetic Variations Of Clopidogrel And Ticagrelor Treatment Among Coronary Artery Disease (CAD) Patients Undergoing Percutaneous Coronary Intervention (PCI) |
| title_sort | study on cyp2c19 genetic variations of clopidogrel and ticagrelor treatment among coronary artery disease cad patients undergoing percutaneous coronary intervention pci |
| topic | RS1-441 Pharmacy and materia medica |
| url | http://eprints.usm.my/60515/1/Pages%20from%20MOHAMMED%20AHMED%20IMRAN%20AK-KAIF%20-%20TESIS.pdf |
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