Stroke associated pneumonia (SAP) among acute ischaemic stroke patients in Hospital Universiti Sains Malaysia : associated factors and clinical outcomes
Background: Stroke-associated pneumonia (SAP) is associated with adverse clinical outcomes which increase the cost of hospitalisation. There are various factors that contribute to SAP among acute ischaemic stroke patients. However, data on SAP in our population are scarce. Hence, a study to deter...
| Main Author: | |
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| Format: | Thesis |
| Language: | English |
| Published: |
2021
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| Subjects: | |
| Online Access: | http://eprints.usm.my/60670/1/SHARIFAH%20NURSAMIHAH-E.pdf |
| _version_ | 1825908326286753792 |
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| author | Rahman, Sharifah Nursamihah Syed Abd |
| author_facet | Rahman, Sharifah Nursamihah Syed Abd |
| author_sort | Rahman, Sharifah Nursamihah Syed Abd |
| collection | USM |
| description | Background: Stroke-associated pneumonia (SAP) is associated with adverse clinical
outcomes which increase the cost of hospitalisation. There are various factors that contribute
to SAP among acute ischaemic stroke patients. However, data on SAP in our population are
scarce. Hence, a study to determine the proportion and associated factors of SAP and its
clinical outcomes is conducted and it is hoped that the findings of this study could guide
future management of patient.
Method: A cross-sectional study among acute ischaemic stroke patients who were admitted
to Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan between January 2016 until
December 2020, were studied. Systematic sampling method were used to select the patient.
Variables collected were demograhics, comorbidities, clinical presentations, treatment of
SAP and clinical outcomes. These variables were then analysed using descriptive, simple
and multiple logistic regression for any significant associations.
Results: 446 subjects with acute ischaemic stroke were selected in this study. Proportion of
SAP is 22.9% (n=102). Significant independent associated factors for SAP are coronary
artery disease (CAD) (OR 2.27, 95% CI (1.12,4.68), p = 0.024), high random blood glucose
on admission (OR 1.152, 95% CI (1.081,1.23), p<0.001), nasogastric tube feeding (OR 4.04,
95% CI (1.91,8.56), p<0.001) and high A2DS2 score (OR 1.58, 95% CI (1.35,1.85), p<0.001).
For the clinical outcomes, SAP has significant association with all outcomes that were
studied; organ impairments (e.g. septic shock, acute kidney injury (AKI), liver dysfunction,
respiratory failure, tracheal intubation, need of trachesotomy), recurrent hospital acquired
infection (HAP), prolonged hospital stays, higher Modified Rankin Scale (MRS) score on
discharge and inpatient mortality, p< 0.05.
Conclusion: The significant independent associated factors for developing SAP are CAD,
high random blood glucose on admission, nasogastric tube feeding and high A2DS2 score.
SAP is significantly associated with adverse outcomes which are organ impairments,
recurrent HAP, prolonged hospital stays, poor MRS score on discharge and inpatient
mortality. Thus, preventive measure of these significant associated factors needs to be done
to reduce incidence of SAP. |
| first_indexed | 2024-09-25T03:56:54Z |
| format | Thesis |
| id | usm.eprints-60670 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-09-25T03:56:54Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | usm.eprints-606702024-07-17T00:48:14Z http://eprints.usm.my/60670/ Stroke associated pneumonia (SAP) among acute ischaemic stroke patients in Hospital Universiti Sains Malaysia : associated factors and clinical outcomes Rahman, Sharifah Nursamihah Syed Abd R Medicine RC648-665 Diseases of the endocrine glands. Clinical endocrinology RC705-779 Diseases of the respiratory system Background: Stroke-associated pneumonia (SAP) is associated with adverse clinical outcomes which increase the cost of hospitalisation. There are various factors that contribute to SAP among acute ischaemic stroke patients. However, data on SAP in our population are scarce. Hence, a study to determine the proportion and associated factors of SAP and its clinical outcomes is conducted and it is hoped that the findings of this study could guide future management of patient. Method: A cross-sectional study among acute ischaemic stroke patients who were admitted to Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan between January 2016 until December 2020, were studied. Systematic sampling method were used to select the patient. Variables collected were demograhics, comorbidities, clinical presentations, treatment of SAP and clinical outcomes. These variables were then analysed using descriptive, simple and multiple logistic regression for any significant associations. Results: 446 subjects with acute ischaemic stroke were selected in this study. Proportion of SAP is 22.9% (n=102). Significant independent associated factors for SAP are coronary artery disease (CAD) (OR 2.27, 95% CI (1.12,4.68), p = 0.024), high random blood glucose on admission (OR 1.152, 95% CI (1.081,1.23), p<0.001), nasogastric tube feeding (OR 4.04, 95% CI (1.91,8.56), p<0.001) and high A2DS2 score (OR 1.58, 95% CI (1.35,1.85), p<0.001). For the clinical outcomes, SAP has significant association with all outcomes that were studied; organ impairments (e.g. septic shock, acute kidney injury (AKI), liver dysfunction, respiratory failure, tracheal intubation, need of trachesotomy), recurrent hospital acquired infection (HAP), prolonged hospital stays, higher Modified Rankin Scale (MRS) score on discharge and inpatient mortality, p< 0.05. Conclusion: The significant independent associated factors for developing SAP are CAD, high random blood glucose on admission, nasogastric tube feeding and high A2DS2 score. SAP is significantly associated with adverse outcomes which are organ impairments, recurrent HAP, prolonged hospital stays, poor MRS score on discharge and inpatient mortality. Thus, preventive measure of these significant associated factors needs to be done to reduce incidence of SAP. 2021 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/60670/1/SHARIFAH%20NURSAMIHAH-E.pdf Rahman, Sharifah Nursamihah Syed Abd (2021) Stroke associated pneumonia (SAP) among acute ischaemic stroke patients in Hospital Universiti Sains Malaysia : associated factors and clinical outcomes. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | R Medicine RC648-665 Diseases of the endocrine glands. Clinical endocrinology RC705-779 Diseases of the respiratory system Rahman, Sharifah Nursamihah Syed Abd Stroke associated pneumonia (SAP) among acute ischaemic stroke patients in Hospital Universiti Sains Malaysia : associated factors and clinical outcomes |
| title | Stroke associated pneumonia (SAP) among acute ischaemic stroke patients in Hospital Universiti Sains Malaysia : associated factors and clinical outcomes |
| title_full | Stroke associated pneumonia (SAP) among acute ischaemic stroke patients in Hospital Universiti Sains Malaysia : associated factors and clinical outcomes |
| title_fullStr | Stroke associated pneumonia (SAP) among acute ischaemic stroke patients in Hospital Universiti Sains Malaysia : associated factors and clinical outcomes |
| title_full_unstemmed | Stroke associated pneumonia (SAP) among acute ischaemic stroke patients in Hospital Universiti Sains Malaysia : associated factors and clinical outcomes |
| title_short | Stroke associated pneumonia (SAP) among acute ischaemic stroke patients in Hospital Universiti Sains Malaysia : associated factors and clinical outcomes |
| title_sort | stroke associated pneumonia sap among acute ischaemic stroke patients in hospital universiti sains malaysia associated factors and clinical outcomes |
| topic | R Medicine RC648-665 Diseases of the endocrine glands. Clinical endocrinology RC705-779 Diseases of the respiratory system |
| url | http://eprints.usm.my/60670/1/SHARIFAH%20NURSAMIHAH-E.pdf |
| work_keys_str_mv | AT rahmansharifahnursamihahsyedabd strokeassociatedpneumoniasapamongacuteischaemicstrokepatientsinhospitaluniversitisainsmalaysiaassociatedfactorsandclinicaloutcomes |