Effect of autologous platelet rich plasma on non-surgical periodontal therapy for periodontitis in selected pakistani patients with uncontrolled type-ii diabetes mellitus
The susceptibility to periodontal disease is often cited as the “sixth complication of diabetes mellitus” making it the most common oral complication of diabetes. Treatment for periodontal disease includes various non-surgical and surgical approaches. The metabolic disturbances in diabetic patien...
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| Format: | Thesis |
| Language: | English |
| Published: |
2023
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| Subjects: | |
| Online Access: | http://eprints.usm.my/60714/1/YOUSAF%20ATHAR%20-%20FINAL%20THESIS%20P-SGD000415%28R%29-E.pdf |
| _version_ | 1811138868186972160 |
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| author | Athar, Yousaf |
| author_facet | Athar, Yousaf |
| author_sort | Athar, Yousaf |
| collection | USM |
| description | The susceptibility to periodontal disease is often cited as the “sixth
complication of diabetes mellitus” making it the most common oral complication of
diabetes. Treatment for periodontal disease includes various non-surgical and surgical
approaches. The metabolic disturbances in diabetic patients may lower their resistance
to infections and may help in both initiation and progression of developing
inflammatory periodontal disease. The use of autologous platelet concentrates has
exhibited considerable promise as a conservative therapy towards periodontal
treatment. The objective of the study was to evaluate the effects of platelet rich plasma
placement in deep periodontal pockets, following non-surgical periodontal therapy
(NSPT) in patients with standardized uncontrolled type II diabetes. The study groups
comprised two patient groups receiving non-surgical periodontal therapy and platelet
rich plasma in two different concentrations and a control group receiving NSPT only.
An inter and Intra group comparison of Periodontal parameters including periodontal
pocket depth, alveolar bone loss and gingival index along with pro-inflammatory
cytokine, Tumour Necrosis Factor Alpha (TNF-α), interleukin 1β (IL-1 β) levels and
C-reactive protein levels was conducted at 45- and 90-day interval. Overall average
age was 50.17 with SD = 7.13. Both interventional groups exhibited statistically
significant gain in bone height. PRP 1 group showed maximum gain in alveolar bone
levels. A trend towards lower HbA1c levels was shown after NSPT and adjunctive PRP placement. The PRP groups exhibited lower the levels of circulating C- reactive
protein. This reduction in levels of pro-inflammatory cytokines in plasma and
improved periodontal parameters indicated a conducive environment towards
periodontal tissue healing and improved diabetic control. |
| first_indexed | 2024-09-25T03:57:02Z |
| format | Thesis |
| id | usm.eprints-60714 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-09-25T03:57:02Z |
| publishDate | 2023 |
| record_format | dspace |
| spelling | usm.eprints-607142024-07-31T07:47:31Z http://eprints.usm.my/60714/ Effect of autologous platelet rich plasma on non-surgical periodontal therapy for periodontitis in selected pakistani patients with uncontrolled type-ii diabetes mellitus Athar, Yousaf R Medicine RA440-440.87 Study and teaching. Research RK641-667 Prosthetic dentistry. Prosthodontics The susceptibility to periodontal disease is often cited as the “sixth complication of diabetes mellitus” making it the most common oral complication of diabetes. Treatment for periodontal disease includes various non-surgical and surgical approaches. The metabolic disturbances in diabetic patients may lower their resistance to infections and may help in both initiation and progression of developing inflammatory periodontal disease. The use of autologous platelet concentrates has exhibited considerable promise as a conservative therapy towards periodontal treatment. The objective of the study was to evaluate the effects of platelet rich plasma placement in deep periodontal pockets, following non-surgical periodontal therapy (NSPT) in patients with standardized uncontrolled type II diabetes. The study groups comprised two patient groups receiving non-surgical periodontal therapy and platelet rich plasma in two different concentrations and a control group receiving NSPT only. An inter and Intra group comparison of Periodontal parameters including periodontal pocket depth, alveolar bone loss and gingival index along with pro-inflammatory cytokine, Tumour Necrosis Factor Alpha (TNF-α), interleukin 1β (IL-1 β) levels and C-reactive protein levels was conducted at 45- and 90-day interval. Overall average age was 50.17 with SD = 7.13. Both interventional groups exhibited statistically significant gain in bone height. PRP 1 group showed maximum gain in alveolar bone levels. A trend towards lower HbA1c levels was shown after NSPT and adjunctive PRP placement. The PRP groups exhibited lower the levels of circulating C- reactive protein. This reduction in levels of pro-inflammatory cytokines in plasma and improved periodontal parameters indicated a conducive environment towards periodontal tissue healing and improved diabetic control. 2023-12 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/60714/1/YOUSAF%20ATHAR%20-%20FINAL%20THESIS%20P-SGD000415%28R%29-E.pdf Athar, Yousaf (2023) Effect of autologous platelet rich plasma on non-surgical periodontal therapy for periodontitis in selected pakistani patients with uncontrolled type-ii diabetes mellitus. PhD thesis, Universiti Sains Malaysia. |
| spellingShingle | R Medicine RA440-440.87 Study and teaching. Research RK641-667 Prosthetic dentistry. Prosthodontics Athar, Yousaf Effect of autologous platelet rich plasma on non-surgical periodontal therapy for periodontitis in selected pakistani patients with uncontrolled type-ii diabetes mellitus |
| title | Effect of autologous platelet rich
plasma on non-surgical periodontal
therapy for periodontitis in selected
pakistani patients with uncontrolled
type-ii diabetes mellitus |
| title_full | Effect of autologous platelet rich
plasma on non-surgical periodontal
therapy for periodontitis in selected
pakistani patients with uncontrolled
type-ii diabetes mellitus |
| title_fullStr | Effect of autologous platelet rich
plasma on non-surgical periodontal
therapy for periodontitis in selected
pakistani patients with uncontrolled
type-ii diabetes mellitus |
| title_full_unstemmed | Effect of autologous platelet rich
plasma on non-surgical periodontal
therapy for periodontitis in selected
pakistani patients with uncontrolled
type-ii diabetes mellitus |
| title_short | Effect of autologous platelet rich
plasma on non-surgical periodontal
therapy for periodontitis in selected
pakistani patients with uncontrolled
type-ii diabetes mellitus |
| title_sort | effect of autologous platelet rich plasma on non surgical periodontal therapy for periodontitis in selected pakistani patients with uncontrolled type ii diabetes mellitus |
| topic | R Medicine RA440-440.87 Study and teaching. Research RK641-667 Prosthetic dentistry. Prosthodontics |
| url | http://eprints.usm.my/60714/1/YOUSAF%20ATHAR%20-%20FINAL%20THESIS%20P-SGD000415%28R%29-E.pdf |
| work_keys_str_mv | AT atharyousaf effectofautologousplateletrichplasmaonnonsurgicalperiodontaltherapyforperiodontitisinselectedpakistanipatientswithuncontrolledtypeiidiabetesmellitus |