Morphological improvements of hypertensive rats thoracic aorta & kidney with syzygium polyanthum
National Health and Morbidity Survey (2015) reported that the prevalence of hypertension in Malaysia for 18 years old and above is higher as compared to our neighboring countries and international standards. Among others, this can be attributed to poor compliance to synthetic antihypertensive dru...
| Main Author: | |
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| Format: | Monograph |
| Language: | English |
| Published: |
Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia
2016
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| Subjects: | |
| Online Access: | http://eprints.usm.my/60740/1/NOR%20%27%20ATIQAH%20BINTI%20MUHAMAD-E.pdf |
| _version_ | 1811138872291098624 |
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| author | Muhamad, Nor 'Atiqah |
| author_facet | Muhamad, Nor 'Atiqah |
| author_sort | Muhamad, Nor 'Atiqah |
| collection | USM |
| description | National Health and Morbidity Survey (2015) reported that the prevalence of
hypertension in Malaysia for 18 years old and above is higher as compared to our
neighboring countries and international standards. Among others, this can be attributed
to poor compliance to synthetic antihypertensive drugs due to their side-effects. Hence,
people nowadays are seeking the alternative herb-based treatment that is familiar to
them. Syzygium polyanthum or “serai kayu” is one of the herbs eaten raw by
Kelantanese. The leaves are traditionally used to reduce blood pressure in hypertensive
patient. Previous study has shown the S.polyanthum leaves extract significantly reduced
the blood pressure in hypertensive rats. The objective of this study is to determine the
effects of oral methanolic extract of S.polyanthum leaves (MESP) on histopathology of
spontaneous hypertensive rat’s (SHR) aorta and kidney. MESP was prepared by
sonication process. The period of the study was 4 weeks (sub-acute) where 1 5 male
SHR were equally divided into 3 groups: Group 1 (MESP 2000 mg/kg), Group 2
(Losartan 10 mg/kg), Group 3 as untreated SHR (negative control for hypertension).
Five male nonnotensive Wistar Kyoto Rats (WKY) served as a negative control (Group
4). All rats were euthanized at the end of the study. Rat’s thoracic aorta and kidney were
examined by hematoxylin and eosin (H&E) staining; also with scanning electron
microscope (SEM). In aorta of MESP-treated, the tunica adventitia and smooth muscle
layer (tunica media) of and Losartan-treated SHR’s aorta was near-normal condition.
Similar improvements in aorta were also noted on SEM. As for kidney, in MESPtreated
SHR and Losartan-treated showed well-preserved glomerulus and well
capsulated of Bowman’s capsule in both H&E and SEM. In conclusion, oral
administrations of Sygyzium polyanthum extract was able to improve the morphological changes in aorta and kidney that are associated with hypertensive changes suggesting
that a promising alternative treatment for hypertension. |
| first_indexed | 2024-09-25T03:57:05Z |
| format | Monograph |
| id | usm.eprints-60740 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-09-25T03:57:05Z |
| publishDate | 2016 |
| publisher | Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia |
| record_format | dspace |
| spelling | usm.eprints-607402024-08-04T07:09:36Z http://eprints.usm.my/60740/ Morphological improvements of hypertensive rats thoracic aorta & kidney with syzygium polyanthum Muhamad, Nor 'Atiqah R Medicine RA440-440.87 Study and teaching. Research RC666-701 Diseases of the circulatory (Cardiovascular) system National Health and Morbidity Survey (2015) reported that the prevalence of hypertension in Malaysia for 18 years old and above is higher as compared to our neighboring countries and international standards. Among others, this can be attributed to poor compliance to synthetic antihypertensive drugs due to their side-effects. Hence, people nowadays are seeking the alternative herb-based treatment that is familiar to them. Syzygium polyanthum or “serai kayu” is one of the herbs eaten raw by Kelantanese. The leaves are traditionally used to reduce blood pressure in hypertensive patient. Previous study has shown the S.polyanthum leaves extract significantly reduced the blood pressure in hypertensive rats. The objective of this study is to determine the effects of oral methanolic extract of S.polyanthum leaves (MESP) on histopathology of spontaneous hypertensive rat’s (SHR) aorta and kidney. MESP was prepared by sonication process. The period of the study was 4 weeks (sub-acute) where 1 5 male SHR were equally divided into 3 groups: Group 1 (MESP 2000 mg/kg), Group 2 (Losartan 10 mg/kg), Group 3 as untreated SHR (negative control for hypertension). Five male nonnotensive Wistar Kyoto Rats (WKY) served as a negative control (Group 4). All rats were euthanized at the end of the study. Rat’s thoracic aorta and kidney were examined by hematoxylin and eosin (H&E) staining; also with scanning electron microscope (SEM). In aorta of MESP-treated, the tunica adventitia and smooth muscle layer (tunica media) of and Losartan-treated SHR’s aorta was near-normal condition. Similar improvements in aorta were also noted on SEM. As for kidney, in MESPtreated SHR and Losartan-treated showed well-preserved glomerulus and well capsulated of Bowman’s capsule in both H&E and SEM. In conclusion, oral administrations of Sygyzium polyanthum extract was able to improve the morphological changes in aorta and kidney that are associated with hypertensive changes suggesting that a promising alternative treatment for hypertension. Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia 2016 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/60740/1/NOR%20%27%20ATIQAH%20BINTI%20MUHAMAD-E.pdf Muhamad, Nor 'Atiqah (2016) Morphological improvements of hypertensive rats thoracic aorta & kidney with syzygium polyanthum. Project Report. Pusat Pengajian Sains Kesihatan, Universiti Sains Malaysia. (Submitted) |
| spellingShingle | R Medicine RA440-440.87 Study and teaching. Research RC666-701 Diseases of the circulatory (Cardiovascular) system Muhamad, Nor 'Atiqah Morphological improvements of hypertensive rats thoracic aorta & kidney with syzygium polyanthum |
| title | Morphological improvements of hypertensive rats thoracic aorta & kidney with syzygium polyanthum |
| title_full | Morphological improvements of hypertensive rats thoracic aorta & kidney with syzygium polyanthum |
| title_fullStr | Morphological improvements of hypertensive rats thoracic aorta & kidney with syzygium polyanthum |
| title_full_unstemmed | Morphological improvements of hypertensive rats thoracic aorta & kidney with syzygium polyanthum |
| title_short | Morphological improvements of hypertensive rats thoracic aorta & kidney with syzygium polyanthum |
| title_sort | morphological improvements of hypertensive rats thoracic aorta kidney with syzygium polyanthum |
| topic | R Medicine RA440-440.87 Study and teaching. Research RC666-701 Diseases of the circulatory (Cardiovascular) system |
| url | http://eprints.usm.my/60740/1/NOR%20%27%20ATIQAH%20BINTI%20MUHAMAD-E.pdf |
| work_keys_str_mv | AT muhamadnoratiqah morphologicalimprovementsofhypertensiveratsthoracicaortakidneywithsyzygiumpolyanthum |