Evaluation of optic nerve head functions and Topography after an episode of optic neuritis
Optic neuritis primarily affects the optic nerve. Most patients with typical optic neuritis have excellent recovery of visual acuity. However, certain degree of optic atrophy will almost always occur and the axonal loss could have consequences especially on other non acuity visual functions. Usin...
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| Format: | Thesis |
| Language: | English |
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2011
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| Online Access: | http://eprints.usm.my/60942/1/CHUA%20CHUI%20YIN%20-%20e.pdf |
| _version_ | 1825908378113671168 |
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| author | Yin, Chua Chui |
| author_facet | Yin, Chua Chui |
| author_sort | Yin, Chua Chui |
| collection | USM |
| description | Optic neuritis primarily affects the optic nerve. Most patients with typical optic neuritis
have excellent recovery of visual acuity. However, certain degree of optic atrophy will
almost always occur and the axonal loss could have consequences especially on other non
acuity visual functions. Using the optic nerve head parameters, it is possible to evaluate
the structural and functional damage of optic nerve after an episode of optic neuritis. To evaluate the optic nerve functions and optic nerve head parameters post single attack
of optic neuritis, and to compare the functional and structural changes based on the
persistence of relative afferent pupillary defect (RAPD). In addition, to correlate the
optic nerve functions and optic nerve head parameters in eyes with post single attack
optic neuritis. The study was conducted from July 2010 to June 2011. Fifty six subjects with history of
single episode of optic neuritis and age-, sex- and race-matched controls underwent
complete ocular examination and optic nerve function tests. In addition to RAPD
examination, LogMAR acuity test, Humphrey visual field 30-2, Functional Acuity
Contrast Test (F.A.C.T®) and Ishihara plates were employed for the assessment of optic
nerve functions. The optic nerve head parameters were measured using Heidelberg Retinal Tomography III (HRT III). Pearson’s correlation was used to determine the correlation
between the optic nerve functions and optic nerve head parameters. Mean duration between recruitment process and first episode of optic neuritis was 5.21 ± 2.94
years. Significant reduction in the optic nerve functions was seen in the optic neuritis group.
Among the optic nerve head parameters, there was significant RNFL thinning (p 0.001),
reduction of neuroretinal rim volume (p =0.006) and increase in the cup shape (p < 0.001), cupdisc
area ratio (p = 0.009) and optic cup area (p = 0.030). The mean RNFL thickness
demonstrated good correlation with the optic nerve functions, in particular contrast sensitivity at
high spatial frequency (r = 0.7351, p < 0.001). There was also fair and inverse correlation
between the cup shape and contrast sensitivity (r= -0.4463, p = 0.016). Subjects with persistent
RAPD showed significant worse performance in visual acuity, colour vision and contrasts
sensitivity score, compare to those without persistent RAPD. However, no significant difference
was seen in the optic nerve head parameters between these two groups. After an episode of optic neuritis, there were significant reduction in optic nerve functions and
changes to the optic nerve head parameters. The thinning of RNFL was especially significant. The good agreement between the optic nerve functions and optic nerve head parameters suggested that in addition to the optic nerve function tests, HRT III is useful for post optic neuritis evaluation. |
| first_indexed | 2024-12-09T02:32:09Z |
| format | Thesis |
| id | usm.eprints-60942 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-12-09T02:32:09Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | usm.eprints-609422024-11-17T06:55:47Z http://eprints.usm.my/60942/ Evaluation of optic nerve head functions and Topography after an episode of optic neuritis Yin, Chua Chui R Medicine (General) RE Ophthalmology Optic neuritis primarily affects the optic nerve. Most patients with typical optic neuritis have excellent recovery of visual acuity. However, certain degree of optic atrophy will almost always occur and the axonal loss could have consequences especially on other non acuity visual functions. Using the optic nerve head parameters, it is possible to evaluate the structural and functional damage of optic nerve after an episode of optic neuritis. To evaluate the optic nerve functions and optic nerve head parameters post single attack of optic neuritis, and to compare the functional and structural changes based on the persistence of relative afferent pupillary defect (RAPD). In addition, to correlate the optic nerve functions and optic nerve head parameters in eyes with post single attack optic neuritis. The study was conducted from July 2010 to June 2011. Fifty six subjects with history of single episode of optic neuritis and age-, sex- and race-matched controls underwent complete ocular examination and optic nerve function tests. In addition to RAPD examination, LogMAR acuity test, Humphrey visual field 30-2, Functional Acuity Contrast Test (F.A.C.T®) and Ishihara plates were employed for the assessment of optic nerve functions. The optic nerve head parameters were measured using Heidelberg Retinal Tomography III (HRT III). Pearson’s correlation was used to determine the correlation between the optic nerve functions and optic nerve head parameters. Mean duration between recruitment process and first episode of optic neuritis was 5.21 ± 2.94 years. Significant reduction in the optic nerve functions was seen in the optic neuritis group. Among the optic nerve head parameters, there was significant RNFL thinning (p 0.001), reduction of neuroretinal rim volume (p =0.006) and increase in the cup shape (p < 0.001), cupdisc area ratio (p = 0.009) and optic cup area (p = 0.030). The mean RNFL thickness demonstrated good correlation with the optic nerve functions, in particular contrast sensitivity at high spatial frequency (r = 0.7351, p < 0.001). There was also fair and inverse correlation between the cup shape and contrast sensitivity (r= -0.4463, p = 0.016). Subjects with persistent RAPD showed significant worse performance in visual acuity, colour vision and contrasts sensitivity score, compare to those without persistent RAPD. However, no significant difference was seen in the optic nerve head parameters between these two groups. After an episode of optic neuritis, there were significant reduction in optic nerve functions and changes to the optic nerve head parameters. The thinning of RNFL was especially significant. The good agreement between the optic nerve functions and optic nerve head parameters suggested that in addition to the optic nerve function tests, HRT III is useful for post optic neuritis evaluation. 2011 Thesis NonPeerReviewed application/pdf en http://eprints.usm.my/60942/1/CHUA%20CHUI%20YIN%20-%20e.pdf Yin, Chua Chui (2011) Evaluation of optic nerve head functions and Topography after an episode of optic neuritis. Masters thesis, Universiti Sains Malaysia. |
| spellingShingle | R Medicine (General) RE Ophthalmology Yin, Chua Chui Evaluation of optic nerve head functions and Topography after an episode of optic neuritis |
| title | Evaluation of optic nerve head functions and
Topography after an episode of optic neuritis |
| title_full | Evaluation of optic nerve head functions and
Topography after an episode of optic neuritis |
| title_fullStr | Evaluation of optic nerve head functions and
Topography after an episode of optic neuritis |
| title_full_unstemmed | Evaluation of optic nerve head functions and
Topography after an episode of optic neuritis |
| title_short | Evaluation of optic nerve head functions and
Topography after an episode of optic neuritis |
| title_sort | evaluation of optic nerve head functions and topography after an episode of optic neuritis |
| topic | R Medicine (General) RE Ophthalmology |
| url | http://eprints.usm.my/60942/1/CHUA%20CHUI%20YIN%20-%20e.pdf |
| work_keys_str_mv | AT yinchuachui evaluationofopticnerveheadfunctionsandtopographyafteranepisodeofopticneuritis |