Dosimetric study of fletcher’s applicator in high-dose-rate (HDR) brachytherapy for cervical cancer: TLD measurements in pelvic water phantom
Background: Intracavitary brachytherapy has become one of the most important treatments for cervical cancer, along with the use of the applicator during its treatment delivery. The most common applicator used is Fletcher’s applicator. To ensure the accurate treatment of brachytherapy, the dose verif...
| Main Author: | |
|---|---|
| Format: | Monograph |
| Language: | English |
| Published: |
Universiti Sains Malaysia
2024
|
| Subjects: | |
| Online Access: | http://eprints.usm.my/61359/1/MUHAMMAD%20NURSYABIL%20BIN%20SALLEHUDIN-E.pdf |
| _version_ | 1824451889371021312 |
|---|---|
| author | Sallehudin,, Muhammad Nursyabil |
| author_facet | Sallehudin,, Muhammad Nursyabil |
| author_sort | Sallehudin,, Muhammad Nursyabil |
| collection | USM |
| description | Background: Intracavitary brachytherapy has become one of the most important treatments for cervical cancer, along with the use of the applicator during its treatment delivery. The most common applicator used is Fletcher’s applicator. To ensure the accurate treatment of brachytherapy, the dose verification of the treatment must be done before the treatment delivery. However, there is a lack of studies on dose verification in cervical cancer brachytherapy that address the discrepancies between the planned dose and the delivered dose using heterogeneous phantoms, especially the one using the Fletcher applicator. Purpose: This study aims to assess the dose distribution and dosimetry performance achieved by the Fletcher’s applicator and perform dose verification in HDR brachytherapy. Materials and Method: The eight sets of thermoluminescence dosimeters (TLD), calibrated using an Iridium-192 source, were placed across the bladder and rectum organ at risk (OAR) inside the heterogenous pelvic water phantom and computed tomography (CT) scanned for image acquisition. The planning of the cervical brachytherapy is done to obtain the calculated TPS dose using the CT image with an 8Gy dose prescription. The phantom is then irradiated along with the TLD to obtain the irradiated TLD-measured dose. The comparison between the TPS calculated dose and the TLD measured dose was done. Results: Two of the eight TLD, G2 (5.883%) and G4 (-17.526%), show a dose deviation less than 20% from the TPS calculated dose, while the other six TLD exceed the 20% dose limit, with G9 showing the highest deviation, -278.726% between the calculated and measured dose. Conclusion: the result of the study shows significant deviation between TPS calculated dose and the TLD measured dose in HDR brachytherapy using Fletcher’s applicator inside heterogenous phantom, with most percentage different exceeding the acceptable tolerance due to several factor mainly the applicator being mispositioned. |
| first_indexed | 2025-02-19T02:41:48Z |
| format | Monograph |
| id | usm.eprints-61359 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2025-02-19T02:41:48Z |
| publishDate | 2024 |
| publisher | Universiti Sains Malaysia |
| record_format | dspace |
| spelling | usm.eprints-613592025-01-06T07:30:22Z http://eprints.usm.my/61359/ Dosimetric study of fletcher’s applicator in high-dose-rate (HDR) brachytherapy for cervical cancer: TLD measurements in pelvic water phantom Sallehudin,, Muhammad Nursyabil R Medicine RC254-282 Neoplasms. Tumors. Oncology (including Cancer) Background: Intracavitary brachytherapy has become one of the most important treatments for cervical cancer, along with the use of the applicator during its treatment delivery. The most common applicator used is Fletcher’s applicator. To ensure the accurate treatment of brachytherapy, the dose verification of the treatment must be done before the treatment delivery. However, there is a lack of studies on dose verification in cervical cancer brachytherapy that address the discrepancies between the planned dose and the delivered dose using heterogeneous phantoms, especially the one using the Fletcher applicator. Purpose: This study aims to assess the dose distribution and dosimetry performance achieved by the Fletcher’s applicator and perform dose verification in HDR brachytherapy. Materials and Method: The eight sets of thermoluminescence dosimeters (TLD), calibrated using an Iridium-192 source, were placed across the bladder and rectum organ at risk (OAR) inside the heterogenous pelvic water phantom and computed tomography (CT) scanned for image acquisition. The planning of the cervical brachytherapy is done to obtain the calculated TPS dose using the CT image with an 8Gy dose prescription. The phantom is then irradiated along with the TLD to obtain the irradiated TLD-measured dose. The comparison between the TPS calculated dose and the TLD measured dose was done. Results: Two of the eight TLD, G2 (5.883%) and G4 (-17.526%), show a dose deviation less than 20% from the TPS calculated dose, while the other six TLD exceed the 20% dose limit, with G9 showing the highest deviation, -278.726% between the calculated and measured dose. Conclusion: the result of the study shows significant deviation between TPS calculated dose and the TLD measured dose in HDR brachytherapy using Fletcher’s applicator inside heterogenous phantom, with most percentage different exceeding the acceptable tolerance due to several factor mainly the applicator being mispositioned. Universiti Sains Malaysia 2024 Monograph NonPeerReviewed application/pdf en http://eprints.usm.my/61359/1/MUHAMMAD%20NURSYABIL%20BIN%20SALLEHUDIN-E.pdf Sallehudin,, Muhammad Nursyabil (2024) Dosimetric study of fletcher’s applicator in high-dose-rate (HDR) brachytherapy for cervical cancer: TLD measurements in pelvic water phantom. Project Report. Universiti Sains Malaysia. (Submitted) |
| spellingShingle | R Medicine RC254-282 Neoplasms. Tumors. Oncology (including Cancer) Sallehudin,, Muhammad Nursyabil Dosimetric study of fletcher’s applicator in high-dose-rate (HDR) brachytherapy for cervical cancer: TLD measurements in pelvic water phantom |
| title | Dosimetric study of fletcher’s applicator in high-dose-rate (HDR) brachytherapy for cervical cancer: TLD measurements in pelvic water phantom |
| title_full | Dosimetric study of fletcher’s applicator in high-dose-rate (HDR) brachytherapy for cervical cancer: TLD measurements in pelvic water phantom |
| title_fullStr | Dosimetric study of fletcher’s applicator in high-dose-rate (HDR) brachytherapy for cervical cancer: TLD measurements in pelvic water phantom |
| title_full_unstemmed | Dosimetric study of fletcher’s applicator in high-dose-rate (HDR) brachytherapy for cervical cancer: TLD measurements in pelvic water phantom |
| title_short | Dosimetric study of fletcher’s applicator in high-dose-rate (HDR) brachytherapy for cervical cancer: TLD measurements in pelvic water phantom |
| title_sort | dosimetric study of fletcher s applicator in high dose rate hdr brachytherapy for cervical cancer tld measurements in pelvic water phantom |
| topic | R Medicine RC254-282 Neoplasms. Tumors. Oncology (including Cancer) |
| url | http://eprints.usm.my/61359/1/MUHAMMAD%20NURSYABIL%20BIN%20SALLEHUDIN-E.pdf |
| work_keys_str_mv | AT sallehudinmuhammadnursyabil dosimetricstudyoffletchersapplicatorinhighdoseratehdrbrachytherapyforcervicalcancertldmeasurementsinpelvicwaterphantom |