Effect Of Spray-dried Ethanolic Extract of Andrographis Paniculata (Burm. F.) Nees On Streptozotocin-induced Diabetic Female Rats.
The objective of this study was to evaluate the effect of commercially prepared spray-dried ethanolic extract ol Andrographis paniculafa (AP) on streptozotocin (STZ)-induced diabetic female rats. METHODOLOGY: Rats with regular estrous cycle (EC) prior to STZ induction were randomly divided into...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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2006
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| Online Access: | http://eprints.usm.my/8170/1/Effect_of_spray-dried_ethanolic_extract_of_Andrographis_paniculata_%28Burm._F.%29_%28Pusat_Pengajian_Sains_Farmasi%29_2008.pdf |
| _version_ | 1797004128297156608 |
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| author | Syahrin, A. S. Amrah, S. S. Ghan, K. L. Lim, B.Y. Hasenan, N. Hasnan, J. Mohsins, S. J. |
| author_facet | Syahrin, A. S. Amrah, S. S. Ghan, K. L. Lim, B.Y. Hasenan, N. Hasnan, J. Mohsins, S. J. |
| author_sort | Syahrin, A. S. |
| collection | USM |
| description | The objective of this study was to evaluate the effect of
commercially prepared spray-dried ethanolic extract
ol Andrographis paniculafa (AP) on streptozotocin
(STZ)-induced diabetic female rats. METHODOLOGY:
Rats with regular estrous cycle (EC) prior to STZ
induction were randomly divided into five groups. The
normal (nondiabetic) and diabetic controlgroups were
given vehicle [0.2 ml of 2o/o carboxyl methyl cellulose
(CMC) by gavagingl daily for 6 weeks. Other diabetic
groups were treated with 50, 100 and 200 mg/kg/day
of AP extracts respectively. The rats' body weight
(BW), fasting blood glucose and insulin level were
measured; and daily, EC evaluation was perfo;.ry1e.d1
throughout the 6-week study period. At the end.olthe
experiment, rats were sacrificed and their P4fprpases
were removed for histological examination."RESU LTS':,
The survival rates and estrous cycle,'$f''AP-treatbd
diabetic animals were found to be improved compared
to nontreated animals.
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| first_indexed | 2024-03-06T13:51:44Z |
| format | Article |
| id | usm.eprints-8170 |
| institution | Universiti Sains Malaysia |
| language | English |
| last_indexed | 2024-03-06T13:51:44Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | usm.eprints-81702017-09-03T22:07:40Z http://eprints.usm.my/8170/ Effect Of Spray-dried Ethanolic Extract of Andrographis Paniculata (Burm. F.) Nees On Streptozotocin-induced Diabetic Female Rats. Syahrin, A. S. Amrah, S. S. Ghan, K. L. Lim, B.Y. Hasenan, N. Hasnan, J. Mohsins, S. J. RB Pathology The objective of this study was to evaluate the effect of commercially prepared spray-dried ethanolic extract ol Andrographis paniculafa (AP) on streptozotocin (STZ)-induced diabetic female rats. METHODOLOGY: Rats with regular estrous cycle (EC) prior to STZ induction were randomly divided into five groups. The normal (nondiabetic) and diabetic controlgroups were given vehicle [0.2 ml of 2o/o carboxyl methyl cellulose (CMC) by gavagingl daily for 6 weeks. Other diabetic groups were treated with 50, 100 and 200 mg/kg/day of AP extracts respectively. The rats' body weight (BW), fasting blood glucose and insulin level were measured; and daily, EC evaluation was perfo;.ry1e.d1 throughout the 6-week study period. At the end.olthe experiment, rats were sacrificed and their P4fprpases were removed for histological examination."RESU LTS':, The survival rates and estrous cycle,'$f''AP-treatbd diabetic animals were found to be improved compared to nontreated animals. 2006-12 Article PeerReviewed application/pdf en http://eprints.usm.my/8170/1/Effect_of_spray-dried_ethanolic_extract_of_Andrographis_paniculata_%28Burm._F.%29_%28Pusat_Pengajian_Sains_Farmasi%29_2008.pdf Syahrin, A. S. and Amrah, S. S. and Ghan, K. L. and Lim, B.Y. and Hasenan, N. and Hasnan, J. and Mohsins, S. J. (2006) Effect Of Spray-dried Ethanolic Extract of Andrographis Paniculata (Burm. F.) Nees On Streptozotocin-induced Diabetic Female Rats. Int J Diab Ctries, 26 (4). pp. 163-168. |
| spellingShingle | RB Pathology Syahrin, A. S. Amrah, S. S. Ghan, K. L. Lim, B.Y. Hasenan, N. Hasnan, J. Mohsins, S. J. Effect Of Spray-dried Ethanolic Extract of Andrographis Paniculata (Burm. F.) Nees On Streptozotocin-induced Diabetic Female Rats. |
| title | Effect Of Spray-dried Ethanolic Extract of Andrographis
Paniculata (Burm. F.) Nees On Streptozotocin-induced Diabetic Female Rats.
|
| title_full | Effect Of Spray-dried Ethanolic Extract of Andrographis
Paniculata (Burm. F.) Nees On Streptozotocin-induced Diabetic Female Rats.
|
| title_fullStr | Effect Of Spray-dried Ethanolic Extract of Andrographis
Paniculata (Burm. F.) Nees On Streptozotocin-induced Diabetic Female Rats.
|
| title_full_unstemmed | Effect Of Spray-dried Ethanolic Extract of Andrographis
Paniculata (Burm. F.) Nees On Streptozotocin-induced Diabetic Female Rats.
|
| title_short | Effect Of Spray-dried Ethanolic Extract of Andrographis
Paniculata (Burm. F.) Nees On Streptozotocin-induced Diabetic Female Rats.
|
| title_sort | effect of spray dried ethanolic extract of andrographis paniculata burm f nees on streptozotocin induced diabetic female rats |
| topic | RB Pathology |
| url | http://eprints.usm.my/8170/1/Effect_of_spray-dried_ethanolic_extract_of_Andrographis_paniculata_%28Burm._F.%29_%28Pusat_Pengajian_Sains_Farmasi%29_2008.pdf |
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