Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells
Long-lasting hyperglycemia can potentially cause damage to organs such as the kidneys, liver and pancreas. Glimepiride (GLIM), as a drug of choice in the treatment of diabetes mellitus (DM), has the risk of decreasing the functioning of organs such as the kidneys, liver and pancreas. Black rice bran...
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| Format: | Article |
| Language: | English |
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2024
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| Online Access: | http://eprints.uthm.edu.my/11125/1/J17619_b9cf95b0fec60784c65fe17b9c1944f4.pdf |
| _version_ | 1825638480092332032 |
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| author | Diski Wahyu Wijianto, Diski Wahyu Wijianto Arifah Sri Wahyuni, Arifah Sri Wahyuni Rizkiananda Wardan, Rizkiananda Wardan Ambar Yunita Nugraheni, Ambar Yunita Nugraheni Abu Bakar, Fazleen Izzany |
| author_facet | Diski Wahyu Wijianto, Diski Wahyu Wijianto Arifah Sri Wahyuni, Arifah Sri Wahyuni Rizkiananda Wardan, Rizkiananda Wardan Ambar Yunita Nugraheni, Ambar Yunita Nugraheni Abu Bakar, Fazleen Izzany |
| author_sort | Diski Wahyu Wijianto, Diski Wahyu Wijianto |
| collection | UTHM |
| description | Long-lasting hyperglycemia can potentially cause damage to organs such as the kidneys, liver and pancreas. Glimepiride (GLIM), as a drug of choice in the treatment of diabetes mellitus (DM), has the risk of decreasing the functioning of organs such as the kidneys, liver and pancreas. Black rice bran ethanol extract (EEBRB) with antioxidant content has been shown to protect the kidney, liver and pancreas organs. The aim of this study was to establish the effect of EEBRB on lowering fasting blood glucose (FBG) and protecting several organs after GLIM administration in alloxan (ALX)-induced hyperglycemic rats. A total of 20 rats were divided into 4 groups and treated for 21 days treatments using following preparations: normal control (NC), diabetic group (DC), GLIM 1 mg/ kgBW and combination of glimepiride 1mg/kgBW and EEBRB 50 mg/KgBW (GLBR). The results showed that the GLBR was able to lower blood glucose levels back to normal (<126 mg/dL) and protect kidney, liver and pancreas cells by increasing the amount in normal cells. |
| first_indexed | 2024-09-24T00:09:42Z |
| format | Article |
| id | uthm.eprints-11125 |
| institution | Universiti Tun Hussein Onn Malaysia |
| language | English |
| last_indexed | 2024-09-24T00:09:42Z |
| publishDate | 2024 |
| record_format | dspace |
| spelling | uthm.eprints-111252024-06-10T02:02:21Z http://eprints.uthm.edu.my/11125/ Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells Diski Wahyu Wijianto, Diski Wahyu Wijianto Arifah Sri Wahyuni, Arifah Sri Wahyuni Rizkiananda Wardan, Rizkiananda Wardan Ambar Yunita Nugraheni, Ambar Yunita Nugraheni Abu Bakar, Fazleen Izzany T Technology (General) Long-lasting hyperglycemia can potentially cause damage to organs such as the kidneys, liver and pancreas. Glimepiride (GLIM), as a drug of choice in the treatment of diabetes mellitus (DM), has the risk of decreasing the functioning of organs such as the kidneys, liver and pancreas. Black rice bran ethanol extract (EEBRB) with antioxidant content has been shown to protect the kidney, liver and pancreas organs. The aim of this study was to establish the effect of EEBRB on lowering fasting blood glucose (FBG) and protecting several organs after GLIM administration in alloxan (ALX)-induced hyperglycemic rats. A total of 20 rats were divided into 4 groups and treated for 21 days treatments using following preparations: normal control (NC), diabetic group (DC), GLIM 1 mg/ kgBW and combination of glimepiride 1mg/kgBW and EEBRB 50 mg/KgBW (GLBR). The results showed that the GLBR was able to lower blood glucose levels back to normal (<126 mg/dL) and protect kidney, liver and pancreas cells by increasing the amount in normal cells. 2024 Article PeerReviewed text en http://eprints.uthm.edu.my/11125/1/J17619_b9cf95b0fec60784c65fe17b9c1944f4.pdf Diski Wahyu Wijianto, Diski Wahyu Wijianto and Arifah Sri Wahyuni, Arifah Sri Wahyuni and Rizkiananda Wardan, Rizkiananda Wardan and Ambar Yunita Nugraheni, Ambar Yunita Nugraheni and Abu Bakar, Fazleen Izzany (2024) Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells. -. pp. 307-314. https://doi.org/10.36721/PJPS.2024.37.2.REG.307-314.1 |
| spellingShingle | T Technology (General) Diski Wahyu Wijianto, Diski Wahyu Wijianto Arifah Sri Wahyuni, Arifah Sri Wahyuni Rizkiananda Wardan, Rizkiananda Wardan Ambar Yunita Nugraheni, Ambar Yunita Nugraheni Abu Bakar, Fazleen Izzany Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells |
| title | Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells |
| title_full | Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells |
| title_fullStr | Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells |
| title_full_unstemmed | Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells |
| title_short | Evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney, liver and pancreatic cells |
| title_sort | evaluation of the combination of black rice bran ethanol extract and glimepiride in reducing blood glucose and protecting kidney liver and pancreatic cells |
| topic | T Technology (General) |
| url | http://eprints.uthm.edu.my/11125/1/J17619_b9cf95b0fec60784c65fe17b9c1944f4.pdf |
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