A review of antioxidant and anti-acetylcholinesterase activities of Centella asiatica (L.) Urb. for the treatment of Alzheimer’s disease
Of many neurodegenerative diseases, Alzheimer’s disease (AD) is the most common cause of dementia globally, which is still incurable even after decades of extensive research to find a definite and permanent cure. Accumulation of free radicals and acetylcholine (ACh) deficiency in the brains of Al...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2021
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| Subjects: | |
| Online Access: | http://eprints.uthm.edu.my/1129/1/J12045_402fa48236c08b540b5f7059f134e710.pdf |
| _version_ | 1796868405627715584 |
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| author | S., Abbas M. S., Latif N. S., Shafie M. I., Ghazali N. A. Z.., Abidin M. K.., Mustafa. F., Kormin |
| author_facet | S., Abbas M. S., Latif N. S., Shafie M. I., Ghazali N. A. Z.., Abidin M. K.., Mustafa. F., Kormin |
| author_sort | S., Abbas |
| collection | UTHM |
| description | Of many neurodegenerative diseases, Alzheimer’s disease (AD) is the most common
cause of dementia globally, which is still incurable even after decades of extensive
research to find a definite and permanent cure. Accumulation of free radicals and
acetylcholine (ACh) deficiency in the brains of Alzheimer’s patients are considered as the
factors leading to dementia and cognitive problems. This is by mechanisms involving
disturbance in the balance between the amount of free radicals and the antioxidant defense
system along with cholinergic deficit leading to impaired cholinergic neurotransmission.
Currently available anti-AD drug therapy carries only the partial benefit of slowing down
the progression of disease besides having various side effects and, hence, there is a
developing interest to search for new drugs. Plants have always been of special interest in
the field of new drug discovery research by virtue of their enormous biological diversity
and tremendous potential of bioactive molecules. Many herbs are known to ameliorate the
symptoms related to memory and cognitive disorders. Centella asiatica (L.) Urb. is one of
the widely used plants claimed by the traditional system of medicine to have its positive
effects on memory and brain functioning. The objective of this review is to present a
comprehensive account on C. asiatica by summarizing the research until date related to its
medicinal potential with a special focus on antioxidant and anti-acetylcholinesterase (anti-
AChE) properties reflecting their potential therapeutic application for the treatment of AD. |
| first_indexed | 2024-03-05T21:39:17Z |
| format | Article |
| id | uthm.eprints-1129 |
| institution | Universiti Tun Hussein Onn Malaysia |
| language | English |
| last_indexed | 2024-03-05T21:39:17Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | uthm.eprints-11292021-10-17T07:52:11Z http://eprints.uthm.edu.my/1129/ A review of antioxidant and anti-acetylcholinesterase activities of Centella asiatica (L.) Urb. for the treatment of Alzheimer’s disease S., Abbas M. S., Latif N. S., Shafie M. I., Ghazali N. A. Z.., Abidin M. K.., Mustafa. F., Kormin R Medicine (General) Of many neurodegenerative diseases, Alzheimer’s disease (AD) is the most common cause of dementia globally, which is still incurable even after decades of extensive research to find a definite and permanent cure. Accumulation of free radicals and acetylcholine (ACh) deficiency in the brains of Alzheimer’s patients are considered as the factors leading to dementia and cognitive problems. This is by mechanisms involving disturbance in the balance between the amount of free radicals and the antioxidant defense system along with cholinergic deficit leading to impaired cholinergic neurotransmission. Currently available anti-AD drug therapy carries only the partial benefit of slowing down the progression of disease besides having various side effects and, hence, there is a developing interest to search for new drugs. Plants have always been of special interest in the field of new drug discovery research by virtue of their enormous biological diversity and tremendous potential of bioactive molecules. Many herbs are known to ameliorate the symptoms related to memory and cognitive disorders. Centella asiatica (L.) Urb. is one of the widely used plants claimed by the traditional system of medicine to have its positive effects on memory and brain functioning. The objective of this review is to present a comprehensive account on C. asiatica by summarizing the research until date related to its medicinal potential with a special focus on antioxidant and anti-acetylcholinesterase (anti- AChE) properties reflecting their potential therapeutic application for the treatment of AD. 2021 Article PeerReviewed text en http://eprints.uthm.edu.my/1129/1/J12045_402fa48236c08b540b5f7059f134e710.pdf S., Abbas and M. S., Latif and N. S., Shafie and M. I., Ghazali and N. A. Z.., Abidin and M. K.., Mustafa. and F., Kormin (2021) A review of antioxidant and anti-acetylcholinesterase activities of Centella asiatica (L.) Urb. for the treatment of Alzheimer’s disease. Food Research, 5 (2). pp. 1-17. https://doi.org/10.26656/fr.2017.5(2).355 |
| spellingShingle | R Medicine (General) S., Abbas M. S., Latif N. S., Shafie M. I., Ghazali N. A. Z.., Abidin M. K.., Mustafa. F., Kormin A review of antioxidant and anti-acetylcholinesterase activities of Centella asiatica (L.) Urb. for the treatment of Alzheimer’s disease |
| title | A review of antioxidant and anti-acetylcholinesterase activities of Centella asiatica (L.) Urb. for the treatment of Alzheimer’s disease |
| title_full | A review of antioxidant and anti-acetylcholinesterase activities of Centella asiatica (L.) Urb. for the treatment of Alzheimer’s disease |
| title_fullStr | A review of antioxidant and anti-acetylcholinesterase activities of Centella asiatica (L.) Urb. for the treatment of Alzheimer’s disease |
| title_full_unstemmed | A review of antioxidant and anti-acetylcholinesterase activities of Centella asiatica (L.) Urb. for the treatment of Alzheimer’s disease |
| title_short | A review of antioxidant and anti-acetylcholinesterase activities of Centella asiatica (L.) Urb. for the treatment of Alzheimer’s disease |
| title_sort | review of antioxidant and anti acetylcholinesterase activities of centella asiatica l urb for the treatment of alzheimer s disease |
| topic | R Medicine (General) |
| url | http://eprints.uthm.edu.my/1129/1/J12045_402fa48236c08b540b5f7059f134e710.pdf |
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