Vitamin D3-loaded electrospun cellulose acetate/polycaprolactone nanofibers: Characterization, in-vitro drug release and cytotoxicity studies
Vitamin D deficiency is nowa global health problem; despite several drug delivery systems for carrying vitaminD due to low bioavailability and loss bioactivity. Developing a new drug delivery system to deliver vitamin D3 is a strong incentive in the current study. Hence, an implantable drug delive...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021
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| Online Access: | http://eprints.uthm.edu.my/1870/1/J12300_97bb4f82d08e2ae93f2de3e642008d59.pdf |
| _version_ | 1825709618487099392 |
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| author | Wsoo, Mohammed Ahmad Abd Razak, Saiful Izwan Mohd Bohari, Siti Pauliena Shahir, Shafinaz Salihu, Rabiu Abdul Kadir, Mohammed Rafiq Mat Nayan, Nadirul Hasraf |
| author_facet | Wsoo, Mohammed Ahmad Abd Razak, Saiful Izwan Mohd Bohari, Siti Pauliena Shahir, Shafinaz Salihu, Rabiu Abdul Kadir, Mohammed Rafiq Mat Nayan, Nadirul Hasraf |
| author_sort | Wsoo, Mohammed Ahmad |
| collection | UTHM |
| description | Vitamin D deficiency is nowa global health problem; despite several drug delivery systems for carrying vitaminD
due to low bioavailability and loss bioactivity. Developing a new drug delivery system to deliver vitamin D3 is a
strong incentive in the current study. Hence, an implantable drug delivery system (IDDS) was developed from
the electrospun cellulose acetate (CA) and ε-polycaprolactone (PCL) nanofibrous membrane, in which the core
of implants consists of vitamin D3-loaded CA nanofiber (CAVD) and enclosed in a thin layer of the PCL membrane
(CAVD/PCL). CA nanofibrousmat loadedwith vitaminD3 at the concentrations of 6, 12, and 20% (w/w) of vitamin
D3 were produced using electrospinning. The smooth and bead-free fibers with diameters ranged from 324 to
428 nm were obtained. The fiber diameters increased with an increase in vitamin D3 content. The controlled
drug release profile was observed over 30-days, which fit with the zero-order model (R2 > 0.96) in the first
stage. The mechanical properties of IDDS were improved. Young's modulus and tensile strength of CAVD/PCL
(dry) were161 ± 14 and 13.07 ± 2.5 MPa, respectively. CA and PCL nanofibers are non-cytotoxic based on the
results of the in-vitro cytotoxicity studies. This study can further broaden in-vivo study and provide a reference
for developing a new IDDS to carry vitamin D3 in the future. |
| first_indexed | 2024-03-05T21:41:18Z |
| format | Article |
| id | uthm.eprints-1870 |
| institution | Universiti Tun Hussein Onn Malaysia |
| language | English |
| last_indexed | 2024-03-05T21:41:18Z |
| publishDate | 2021 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | uthm.eprints-18702021-10-18T06:51:12Z http://eprints.uthm.edu.my/1870/ Vitamin D3-loaded electrospun cellulose acetate/polycaprolactone nanofibers: Characterization, in-vitro drug release and cytotoxicity studies Wsoo, Mohammed Ahmad Abd Razak, Saiful Izwan Mohd Bohari, Siti Pauliena Shahir, Shafinaz Salihu, Rabiu Abdul Kadir, Mohammed Rafiq Mat Nayan, Nadirul Hasraf QP Physiology Vitamin D deficiency is nowa global health problem; despite several drug delivery systems for carrying vitaminD due to low bioavailability and loss bioactivity. Developing a new drug delivery system to deliver vitamin D3 is a strong incentive in the current study. Hence, an implantable drug delivery system (IDDS) was developed from the electrospun cellulose acetate (CA) and ε-polycaprolactone (PCL) nanofibrous membrane, in which the core of implants consists of vitamin D3-loaded CA nanofiber (CAVD) and enclosed in a thin layer of the PCL membrane (CAVD/PCL). CA nanofibrousmat loadedwith vitaminD3 at the concentrations of 6, 12, and 20% (w/w) of vitamin D3 were produced using electrospinning. The smooth and bead-free fibers with diameters ranged from 324 to 428 nm were obtained. The fiber diameters increased with an increase in vitamin D3 content. The controlled drug release profile was observed over 30-days, which fit with the zero-order model (R2 > 0.96) in the first stage. The mechanical properties of IDDS were improved. Young's modulus and tensile strength of CAVD/PCL (dry) were161 ± 14 and 13.07 ± 2.5 MPa, respectively. CA and PCL nanofibers are non-cytotoxic based on the results of the in-vitro cytotoxicity studies. This study can further broaden in-vivo study and provide a reference for developing a new IDDS to carry vitamin D3 in the future. Elsevier 2021 Article PeerReviewed text en http://eprints.uthm.edu.my/1870/1/J12300_97bb4f82d08e2ae93f2de3e642008d59.pdf Wsoo, Mohammed Ahmad and Abd Razak, Saiful Izwan and Mohd Bohari, Siti Pauliena and Shahir, Shafinaz and Salihu, Rabiu and Abdul Kadir, Mohammed Rafiq and Mat Nayan, Nadirul Hasraf (2021) Vitamin D3-loaded electrospun cellulose acetate/polycaprolactone nanofibers: Characterization, in-vitro drug release and cytotoxicity studies. International Journal of Biological Macromolecules, 181. pp. 82-98. ISSN 0141-8130 https://doi.org/10.1016/j.ijbiomac.2021.03.108 |
| spellingShingle | QP Physiology Wsoo, Mohammed Ahmad Abd Razak, Saiful Izwan Mohd Bohari, Siti Pauliena Shahir, Shafinaz Salihu, Rabiu Abdul Kadir, Mohammed Rafiq Mat Nayan, Nadirul Hasraf Vitamin D3-loaded electrospun cellulose acetate/polycaprolactone nanofibers: Characterization, in-vitro drug release and cytotoxicity studies |
| title | Vitamin D3-loaded electrospun cellulose acetate/polycaprolactone
nanofibers: Characterization, in-vitro drug release and
cytotoxicity studies |
| title_full | Vitamin D3-loaded electrospun cellulose acetate/polycaprolactone
nanofibers: Characterization, in-vitro drug release and
cytotoxicity studies |
| title_fullStr | Vitamin D3-loaded electrospun cellulose acetate/polycaprolactone
nanofibers: Characterization, in-vitro drug release and
cytotoxicity studies |
| title_full_unstemmed | Vitamin D3-loaded electrospun cellulose acetate/polycaprolactone
nanofibers: Characterization, in-vitro drug release and
cytotoxicity studies |
| title_short | Vitamin D3-loaded electrospun cellulose acetate/polycaprolactone
nanofibers: Characterization, in-vitro drug release and
cytotoxicity studies |
| title_sort | vitamin d3 loaded electrospun cellulose acetate polycaprolactone nanofibers characterization in vitro drug release and cytotoxicity studies |
| topic | QP Physiology |
| url | http://eprints.uthm.edu.my/1870/1/J12300_97bb4f82d08e2ae93f2de3e642008d59.pdf |
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