Anti-gout potential of selected Malaysian local fruits
This study aimed to investigate the in vitro xanthine oxidase (XO) inhibitory activity and phytochemical content of guava, water rose apple, Malay gooseberry, pineapple and ambarella. The xanthine oxidase inhibitory activity was measured spectrophotometrically at 295 nm. The phytochemical analysi...
| Main Authors: | , , , , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
2021
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| Subjects: | |
| Online Access: | http://eprints.uthm.edu.my/2612/1/P12652_5d57f15a121f634e264ef7dc77676f7c.pdf |
| _version_ | 1796868681089679360 |
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| author | Wan Aziz, W. N. A. Abu Bakar, M. F. Abu Bakar, F. I. Dheyab, A. S. Sabran, S. F. Kormin, F. |
| author_facet | Wan Aziz, W. N. A. Abu Bakar, M. F. Abu Bakar, F. I. Dheyab, A. S. Sabran, S. F. Kormin, F. |
| author_sort | Wan Aziz, W. N. A. |
| collection | UTHM |
| description | This study aimed to investigate the in vitro xanthine oxidase (XO) inhibitory activity
and phytochemical content of guava, water rose apple, Malay gooseberry, pineapple and
ambarella. The xanthine oxidase inhibitory activity was measured spectrophotometrically at 295
nm. The phytochemical analysis tested were total phenolic, total flavonoid and total anthocyanin
contents of each methanolic extract of the fruits. The highest amount of phenolic was found in
ambarella (0.245 mg GAE/g) while guava had the highest amount of flavonoid (0.472 mg RE/g).
Meanwhile, water rose apple had the highest anthocyanin content (5.001 mg c-3-gE/g). For the
XO inhibitory activity, water rose apple displayed the lowest IC50 value (26.86 μg/mL), showing
better anti-gout activity as compared to that of other fruit samples. Positive correlation between
total phenolic content and XO inhibitory activity was also observed in this study. Further study
on the isolation of bioactive compounds from the fruit samples that act as XO inhibitor is greatly
needed in the future. |
| first_indexed | 2024-03-05T21:43:26Z |
| format | Conference or Workshop Item |
| id | uthm.eprints-2612 |
| institution | Universiti Tun Hussein Onn Malaysia |
| language | English |
| last_indexed | 2024-03-05T21:43:26Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | uthm.eprints-26122021-10-25T06:56:34Z http://eprints.uthm.edu.my/2612/ Anti-gout potential of selected Malaysian local fruits Wan Aziz, W. N. A. Abu Bakar, M. F. Abu Bakar, F. I. Dheyab, A. S. Sabran, S. F. Kormin, F. TP200-248 Chemicals: Manufacture, use, etc. This study aimed to investigate the in vitro xanthine oxidase (XO) inhibitory activity and phytochemical content of guava, water rose apple, Malay gooseberry, pineapple and ambarella. The xanthine oxidase inhibitory activity was measured spectrophotometrically at 295 nm. The phytochemical analysis tested were total phenolic, total flavonoid and total anthocyanin contents of each methanolic extract of the fruits. The highest amount of phenolic was found in ambarella (0.245 mg GAE/g) while guava had the highest amount of flavonoid (0.472 mg RE/g). Meanwhile, water rose apple had the highest anthocyanin content (5.001 mg c-3-gE/g). For the XO inhibitory activity, water rose apple displayed the lowest IC50 value (26.86 μg/mL), showing better anti-gout activity as compared to that of other fruit samples. Positive correlation between total phenolic content and XO inhibitory activity was also observed in this study. Further study on the isolation of bioactive compounds from the fruit samples that act as XO inhibitor is greatly needed in the future. 2021 Conference or Workshop Item PeerReviewed text en http://eprints.uthm.edu.my/2612/1/P12652_5d57f15a121f634e264ef7dc77676f7c.pdf Wan Aziz, W. N. A. and Abu Bakar, M. F. and Abu Bakar, F. I. and Dheyab, A. S. and Sabran, S. F. and Kormin, F. (2021) Anti-gout potential of selected Malaysian local fruits. In: International Conference on Biodiversity 2020, November 4-5, 2020, Melaka, Malaysia. https://doi.org/10.1088/1755-1315/736/1/012069 |
| spellingShingle | TP200-248 Chemicals: Manufacture, use, etc. Wan Aziz, W. N. A. Abu Bakar, M. F. Abu Bakar, F. I. Dheyab, A. S. Sabran, S. F. Kormin, F. Anti-gout potential of selected Malaysian local fruits |
| title | Anti-gout potential of selected Malaysian local fruits |
| title_full | Anti-gout potential of selected Malaysian local fruits |
| title_fullStr | Anti-gout potential of selected Malaysian local fruits |
| title_full_unstemmed | Anti-gout potential of selected Malaysian local fruits |
| title_short | Anti-gout potential of selected Malaysian local fruits |
| title_sort | anti gout potential of selected malaysian local fruits |
| topic | TP200-248 Chemicals: Manufacture, use, etc. |
| url | http://eprints.uthm.edu.my/2612/1/P12652_5d57f15a121f634e264ef7dc77676f7c.pdf |
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