Synthesis and physical properties of chitosan/alginate/silver nanoparticles hydrogel scaffolds
A biodegradable scaffold in tissue engineering serves as a temporary skeleton to accommodate and stimulate new tissue growth. Alginate (Alg) and chitosan (Chi) are both popular materials applied as biomaterials or bioimplants. However, Alg derived from brown algae is highly compliant and easily deco...
| Main Authors: | , , , , |
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| Format: | Book Section |
| Language: | English |
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Penerbit Uthm
2019
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| Online Access: | http://eprints.uthm.edu.my/3579/1/c%207%20DONE.pdf |
| _version_ | 1825637102882127872 |
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| author | Ramli, Roslinda Hani Soon, Chin Fhong Ahmad, Mohd Khairul Nayan, Nafarizal Mohd Rus, Anika Zafiah |
| author_facet | Ramli, Roslinda Hani Soon, Chin Fhong Ahmad, Mohd Khairul Nayan, Nafarizal Mohd Rus, Anika Zafiah |
| author_sort | Ramli, Roslinda Hani |
| collection | UTHM |
| description | A biodegradable scaffold in tissue engineering serves as a temporary skeleton to accommodate and stimulate new tissue growth. Alginate (Alg) and chitosan (Chi) are both popular materials applied as biomaterials or bioimplants. However, Alg derived from brown algae is highly compliant and easily decomposed in fluid, whilst Chi derived from shrimp shells has weak strength. In rectify these problems, the development of Chi and Alg based biodegradable scaffolds incorporated with silver nanoparticles (AgNPs) with enhanced mechanical properties and biosafe function is proposed. Different ratios of chitosan/alginate (Chi/Alg) were prepared and the effect of different ratio (1:1, 1:2 and 2:1) to the mechanical with and without AgNPs were investigated. Meanwhile, swelling/degradation test and dynamic mechanical analysis (DMA) were conducted to study the properties of Chi/Alg based scaffold. Swelling/degradation test and DMA show that Chi/Alg and chitosan/alginate/silver (Chi/Alg/AgNPs) nanoparticles has adequate swelling and compressive modulus that exceed the epidermis’ Young modulus, thus able to provide mechanical support upon application. As a result, the incorporation of chitosan in the Alg and AgNPs improved physical and mechanical properties of hydrogel itself and provide biosafe environment during the study.
Keywords: bio-composite, silver nanoparticles, alginate, chitosan, hydrogel, mechanical properties |
| first_indexed | 2024-03-05T21:46:12Z |
| format | Book Section |
| id | uthm.eprints-3579 |
| institution | Universiti Tun Hussein Onn Malaysia |
| language | English |
| last_indexed | 2024-03-05T21:46:12Z |
| publishDate | 2019 |
| publisher | Penerbit Uthm |
| record_format | dspace |
| spelling | uthm.eprints-35792022-01-10T03:41:21Z http://eprints.uthm.edu.my/3579/ Synthesis and physical properties of chitosan/alginate/silver nanoparticles hydrogel scaffolds Ramli, Roslinda Hani Soon, Chin Fhong Ahmad, Mohd Khairul Nayan, Nafarizal Mohd Rus, Anika Zafiah TK7800-8360 Electronics A biodegradable scaffold in tissue engineering serves as a temporary skeleton to accommodate and stimulate new tissue growth. Alginate (Alg) and chitosan (Chi) are both popular materials applied as biomaterials or bioimplants. However, Alg derived from brown algae is highly compliant and easily decomposed in fluid, whilst Chi derived from shrimp shells has weak strength. In rectify these problems, the development of Chi and Alg based biodegradable scaffolds incorporated with silver nanoparticles (AgNPs) with enhanced mechanical properties and biosafe function is proposed. Different ratios of chitosan/alginate (Chi/Alg) were prepared and the effect of different ratio (1:1, 1:2 and 2:1) to the mechanical with and without AgNPs were investigated. Meanwhile, swelling/degradation test and dynamic mechanical analysis (DMA) were conducted to study the properties of Chi/Alg based scaffold. Swelling/degradation test and DMA show that Chi/Alg and chitosan/alginate/silver (Chi/Alg/AgNPs) nanoparticles has adequate swelling and compressive modulus that exceed the epidermis’ Young modulus, thus able to provide mechanical support upon application. As a result, the incorporation of chitosan in the Alg and AgNPs improved physical and mechanical properties of hydrogel itself and provide biosafe environment during the study. Keywords: bio-composite, silver nanoparticles, alginate, chitosan, hydrogel, mechanical properties Penerbit Uthm 2019 Book Section PeerReviewed text en http://eprints.uthm.edu.my/3579/1/c%207%20DONE.pdf Ramli, Roslinda Hani and Soon, Chin Fhong and Ahmad, Mohd Khairul and Nayan, Nafarizal and Mohd Rus, Anika Zafiah (2019) Synthesis and physical properties of chitosan/alginate/silver nanoparticles hydrogel scaffolds. In: Current Advances in Microdevices and Nanotechnology. Penerbit Uthm, Uthm, pp. 131-147. ISBN 978-967-2306-25-2 |
| spellingShingle | TK7800-8360 Electronics Ramli, Roslinda Hani Soon, Chin Fhong Ahmad, Mohd Khairul Nayan, Nafarizal Mohd Rus, Anika Zafiah Synthesis and physical properties of chitosan/alginate/silver nanoparticles hydrogel scaffolds |
| title | Synthesis and physical properties of chitosan/alginate/silver nanoparticles hydrogel scaffolds |
| title_full | Synthesis and physical properties of chitosan/alginate/silver nanoparticles hydrogel scaffolds |
| title_fullStr | Synthesis and physical properties of chitosan/alginate/silver nanoparticles hydrogel scaffolds |
| title_full_unstemmed | Synthesis and physical properties of chitosan/alginate/silver nanoparticles hydrogel scaffolds |
| title_short | Synthesis and physical properties of chitosan/alginate/silver nanoparticles hydrogel scaffolds |
| title_sort | synthesis and physical properties of chitosan alginate silver nanoparticles hydrogel scaffolds |
| topic | TK7800-8360 Electronics |
| url | http://eprints.uthm.edu.my/3579/1/c%207%20DONE.pdf |
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