Anti-gout potential of Malaysian medicinal plants
Gout is a type of arthritis that causes painful inflammation in one or more joints. In gout, elevation of uric acid in the blood triggers the formation of crystals, causing joint pain. Malaysia is a mega-biodiversity country that is rich in medicinal plants species. Therefore, its flora might offer...
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| 格式: | 文件 |
| 语言: | English |
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Frontiers Media S.A.
2018
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| 在线阅读: | http://eprints.uthm.edu.my/5115/1/AJ%202018%20%28151%29.pdf |
| _version_ | 1825709966951972864 |
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| author | Abu Bakar, Fazleen I. Abu Bakar, Mohd F. Rahmat, Asmah Abdullah, Norazlin Sabran, Siti F. Endrini, Susi |
| author_facet | Abu Bakar, Fazleen I. Abu Bakar, Mohd F. Rahmat, Asmah Abdullah, Norazlin Sabran, Siti F. Endrini, Susi |
| author_sort | Abu Bakar, Fazleen I. |
| collection | UTHM |
| description | Gout is a type of arthritis that causes painful inflammation in one or more joints. In gout, elevation of uric acid in the blood triggers the formation of crystals, causing joint pain. Malaysia is a mega-biodiversity country that is rich in medicinal plants species. Therefore, its flora might offer promising therapies for gout. This article aims to systematically review the anti-gout potential of Malaysian medicinal plants. Articles on gout published from 2000 to 2017 were identified using PubMed, Scopus, ScienceDirect, and Google Scholar with the following keyword search terms: “gout,” “medicinal plants,” “Malaysia,” “epidemiology,” “in vitro,” and “in vivo.” In this study, 85 plants were identified as possessing anti-gout activity. These plants had higher percentages of xanthine oxidase inhibitory activity (>85%); specifically, the Momordica charantia, Chrysanthemum indicum, Cinnamomum cassia, Kaempferia galanga, Artemisia vulgaris, and Morinda elliptica had the highest values, due to their diverse natural bioactive compounds, which include flavonoids, phenolics, tannin, coumarins, luteolin, and apigenin. This review summarizes the anti-gout potential of Malaysian medicinal plants but the mechanisms, active compounds, pharmacokinetics, bioavailability, and safety of the plants still remain to be elucidated. |
| first_indexed | 2024-03-05T21:50:26Z |
| format | Article |
| id | uthm.eprints-5115 |
| institution | Universiti Tun Hussein Onn Malaysia |
| language | English |
| last_indexed | 2024-03-05T21:50:26Z |
| publishDate | 2018 |
| publisher | Frontiers Media S.A. |
| record_format | dspace |
| spelling | uthm.eprints-51152022-01-05T08:43:50Z http://eprints.uthm.edu.my/5115/ Anti-gout potential of Malaysian medicinal plants Abu Bakar, Fazleen I. Abu Bakar, Mohd F. Rahmat, Asmah Abdullah, Norazlin Sabran, Siti F. Endrini, Susi R Medicine (General) RV Botanic, Thomsonian, and eclectic medicine T Technology (General) QK710-899 Plant physiology Gout is a type of arthritis that causes painful inflammation in one or more joints. In gout, elevation of uric acid in the blood triggers the formation of crystals, causing joint pain. Malaysia is a mega-biodiversity country that is rich in medicinal plants species. Therefore, its flora might offer promising therapies for gout. This article aims to systematically review the anti-gout potential of Malaysian medicinal plants. Articles on gout published from 2000 to 2017 were identified using PubMed, Scopus, ScienceDirect, and Google Scholar with the following keyword search terms: “gout,” “medicinal plants,” “Malaysia,” “epidemiology,” “in vitro,” and “in vivo.” In this study, 85 plants were identified as possessing anti-gout activity. These plants had higher percentages of xanthine oxidase inhibitory activity (>85%); specifically, the Momordica charantia, Chrysanthemum indicum, Cinnamomum cassia, Kaempferia galanga, Artemisia vulgaris, and Morinda elliptica had the highest values, due to their diverse natural bioactive compounds, which include flavonoids, phenolics, tannin, coumarins, luteolin, and apigenin. This review summarizes the anti-gout potential of Malaysian medicinal plants but the mechanisms, active compounds, pharmacokinetics, bioavailability, and safety of the plants still remain to be elucidated. Frontiers Media S.A. 2018 Article PeerReviewed text en http://eprints.uthm.edu.my/5115/1/AJ%202018%20%28151%29.pdf Abu Bakar, Fazleen I. and Abu Bakar, Mohd F. and Rahmat, Asmah and Abdullah, Norazlin and Sabran, Siti F. and Endrini, Susi (2018) Anti-gout potential of Malaysian medicinal plants. FRONTIERS IN PHARMACOLOGY, 9. pp. 1-14. ISSN 16639812 https://doi.org/10.3389/fphar.2018.00261 |
| spellingShingle | R Medicine (General) RV Botanic, Thomsonian, and eclectic medicine T Technology (General) QK710-899 Plant physiology Abu Bakar, Fazleen I. Abu Bakar, Mohd F. Rahmat, Asmah Abdullah, Norazlin Sabran, Siti F. Endrini, Susi Anti-gout potential of Malaysian medicinal plants |
| title | Anti-gout potential of Malaysian medicinal plants |
| title_full | Anti-gout potential of Malaysian medicinal plants |
| title_fullStr | Anti-gout potential of Malaysian medicinal plants |
| title_full_unstemmed | Anti-gout potential of Malaysian medicinal plants |
| title_short | Anti-gout potential of Malaysian medicinal plants |
| title_sort | anti gout potential of malaysian medicinal plants |
| topic | R Medicine (General) RV Botanic, Thomsonian, and eclectic medicine T Technology (General) QK710-899 Plant physiology |
| url | http://eprints.uthm.edu.my/5115/1/AJ%202018%20%28151%29.pdf |
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