Reentrant excitation in an analog-digital hybrid circuit model of cardiac tissue
We propose an analog-digital hybrid circuit model of one-dimensional cardiac tissue with hardware implementation that allows us to perform real-time simulations of spatially conducting cardiac action potentials. Each active nodal compartment of the tissue model is designed using analog circuits and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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2011
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| Online Access: | http://eprints.uthm.edu.my/7933/1/J14510_1d203e49b67bf135e0e7393884fc5030.pdf |
| _version_ | 1796869660619046912 |
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| author | Mahmud, Farhanahani Shiozawa, Naruhiro Makikawa, Masaaki Nomura, Taishin |
| author_facet | Mahmud, Farhanahani Shiozawa, Naruhiro Makikawa, Masaaki Nomura, Taishin |
| author_sort | Mahmud, Farhanahani |
| collection | UTHM |
| description | We propose an analog-digital hybrid circuit model of one-dimensional cardiac tissue with hardware implementation that allows us to perform real-time simulations of spatially conducting cardiac action potentials. Each active nodal compartment of the tissue model is designed using analog circuits and a dsPIC microcontroller, by which the time-dependent and time-independent nonlinear current-voltage relationships of six types of ion channel currents employed in the Luo-Rudy phase I (LR-I) model for a single mammalian cardiac ventricular cell can be reproduced quantitatively. Here, we perform real-time simulations of reentrant excitation conduction in a ring-shaped tissue model that includes eighty nodal compartments. In particular, we show that the hybrid tissue model can exhibit real-time dynamics for initiation of reentries induced by uni-directional block, as well as those for phase resetting that leads to annihilation of the reentry in response to impulsive current stimulations at appropriate nodes and timings. The dynamics of the hybrid model are comparable to those of a spatially distributed tissue model with LR-I compartments. Thus, it is conceivable that the hybrid model might be a useful tool for large scale simulations of cardiac tissue dynamics, as an alternative to numerical simulations, leading toward further understanding of the reentrant mechanisms. |
| first_indexed | 2024-03-05T21:58:11Z |
| format | Article |
| id | uthm.eprints-7933 |
| institution | Universiti Tun Hussein Onn Malaysia |
| language | English |
| last_indexed | 2024-03-05T21:58:11Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | uthm.eprints-79332022-10-30T08:04:48Z http://eprints.uthm.edu.my/7933/ Reentrant excitation in an analog-digital hybrid circuit model of cardiac tissue Mahmud, Farhanahani Shiozawa, Naruhiro Makikawa, Masaaki Nomura, Taishin T Technology (General) We propose an analog-digital hybrid circuit model of one-dimensional cardiac tissue with hardware implementation that allows us to perform real-time simulations of spatially conducting cardiac action potentials. Each active nodal compartment of the tissue model is designed using analog circuits and a dsPIC microcontroller, by which the time-dependent and time-independent nonlinear current-voltage relationships of six types of ion channel currents employed in the Luo-Rudy phase I (LR-I) model for a single mammalian cardiac ventricular cell can be reproduced quantitatively. Here, we perform real-time simulations of reentrant excitation conduction in a ring-shaped tissue model that includes eighty nodal compartments. In particular, we show that the hybrid tissue model can exhibit real-time dynamics for initiation of reentries induced by uni-directional block, as well as those for phase resetting that leads to annihilation of the reentry in response to impulsive current stimulations at appropriate nodes and timings. The dynamics of the hybrid model are comparable to those of a spatially distributed tissue model with LR-I compartments. Thus, it is conceivable that the hybrid model might be a useful tool for large scale simulations of cardiac tissue dynamics, as an alternative to numerical simulations, leading toward further understanding of the reentrant mechanisms. 2011 Article PeerReviewed text en http://eprints.uthm.edu.my/7933/1/J14510_1d203e49b67bf135e0e7393884fc5030.pdf Mahmud, Farhanahani and Shiozawa, Naruhiro and Makikawa, Masaaki and Nomura, Taishin (2011) Reentrant excitation in an analog-digital hybrid circuit model of cardiac tissue. Chaos: An Interdisciplinary Journal of Nonlinear Science, 21 (2). https://doi.org/10.1063/1.3597645 |
| spellingShingle | T Technology (General) Mahmud, Farhanahani Shiozawa, Naruhiro Makikawa, Masaaki Nomura, Taishin Reentrant excitation in an analog-digital hybrid circuit model of cardiac tissue |
| title | Reentrant excitation in an analog-digital hybrid circuit model of cardiac tissue |
| title_full | Reentrant excitation in an analog-digital hybrid circuit model of cardiac tissue |
| title_fullStr | Reentrant excitation in an analog-digital hybrid circuit model of cardiac tissue |
| title_full_unstemmed | Reentrant excitation in an analog-digital hybrid circuit model of cardiac tissue |
| title_short | Reentrant excitation in an analog-digital hybrid circuit model of cardiac tissue |
| title_sort | reentrant excitation in an analog digital hybrid circuit model of cardiac tissue |
| topic | T Technology (General) |
| url | http://eprints.uthm.edu.my/7933/1/J14510_1d203e49b67bf135e0e7393884fc5030.pdf |
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